{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:55:54Z","timestamp":1787316954883,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008542","name":"Arthroscopy Association of North America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011549","name":"American Orthopaedic Society for Sports Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007307","name":"Arthrex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013894","name":"International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013894","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the efficacy of selective interleukin (IL)\u20101 inhibitor therapy in the reduction of posttraumatic osteoarthritis (PTOA) progression following knee ligament or meniscal injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted evaluating the disease\u2010modifying efficacy of selective IL\u20101 inhibition in the setting of knee PTOA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The literature search identified 364 articles and 11 studies were included (n\u00a0= 10 preclinical, n\u00a0= 1 clinical). Drug delivery in preclinical studies was administered using IL\u20101Ra\u2013encoded helper\u2010dependent adenovirus particles (n\u00a0= 3), synovial cells transfected with an IL\u20101Ra\u2013encoded retroviral vector (n\u00a0= 3), or varying chemical compositions of nonviral microcapsule gene carriers (n\u00a0= 4). Intervention with selective IL\u20101 inhibitor therapy within 2 weeks of injury provided the greatest protective benefits in reducing the progression of PTOA regardless of drug delivery methodology in preclinical models. The majority of studies reported significantly better cartilage integrity and reduction in lesion size in animals treated with gene therapy with the greatest effects seen in those treated within 5 to 7 days of injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early intervention with selective IL\u20101 inhibitor therapy were effective in reducing proinflammatory IL\u20101\u03b2 levels in the acute and subacute phases following traumatic knee injury in preclinical animal model studies, while significantly reducing cartilage damage, lesion size, and PTOA progression at short\u2010term follow\u2010up. However, it was found that the effect of these therapies diminished over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Acute, intra\u2010articular injection of selective IL\u20101 inhibitors may reduce PTOA progression, supporting the need for additional basic and clinical investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2022.02.009","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T21:03:02Z","timestamp":1645218182000},"page":"2543-2556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Acute Intervention With Selective Interleukin\u20101 Inhibitor Therapy May Reduce the Progression of Posttraumatic Osteoarthritis of the Knee: A Systematic Review of Current Evidence"],"prefix":"10.1002","volume":"38","author":[{"given":"Zachary S.","family":"Aman","sequence":"first","affiliation":[{"name":"Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas N.","family":"DePhillipo","sequence":"additional","affiliation":[{"name":"Oslo Sports Trauma Research Center Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Familiari","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery Magna Graecia University Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan F.","family":"Dickens","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center Bethesda Maryland U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"LaPrade","sequence":"additional","affiliation":[{"name":"Twin Cities Orthopedics Edina Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis J.","family":"Dekker","sequence":"additional","affiliation":[{"name":"Eglin Air Force Base Eglin Florida U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512448177"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517730072"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546521993818"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20589"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.008136"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1536012117714575"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2014.02.001"},{"key":"e_1_2_2_9_2","first-page":"4","article-title":"National and state medical expenditures and lost earnings attributable to arthritis and other rheumatic condition\u2014United States, 2003","volume":"56","author":"Centers for Disease Control and Prevention (CDC)","year":"2007","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)30417\u20109"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.03.050"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v034a21"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.12.009"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.08.015"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010020\u201002156\u20105"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i1.95"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.12.035"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390914"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529\u20100131(200005)43:5<1001::AID\u2010ANR7>3.0.CO;2\u2010P"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.12.4181"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.2165\/11599350\u2010000000000\u201000000"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40668"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2018.106"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200608020-00009"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400604"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12611"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2003.12.007"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.171"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2015.1009942"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.11.006"},{"key":"e_1_2_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30361"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041996"},{"key":"e_1_2_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22208"},{"key":"e_1_2_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0968\u20100160(02)00083\u20102"},{"key":"e_1_2_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39677"},{"key":"e_1_2_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10195\u2010017\u20100473\u20108"},{"key":"e_1_2_2_38_2","first-page":"1317","article-title":"Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: A multicenter study","volume":"32","author":"Chevalier X.","year":"2005","journal-title":"J\u00a0Rheumatol"},{"key":"e_1_2_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24096"},{"key":"e_1_2_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.121"},{"key":"e_1_2_2_41_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2005.16.1"},{"key":"e_1_2_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0169\u2010409x(98)00048\u20109"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806322000950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806322000950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2022.02.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2022.02.009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2022.02.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:00:43Z","timestamp":1773565243000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2022.02.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,18]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1016\/j.arthro.2022.02.009"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2022.02.009","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,18]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Intervention With Selective Interleukin-1 Inhibitor Therapy May Reduce the Progression of Posttraumatic Osteoarthritis of the Knee: A Systematic Review of Current Evidence","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy: The Journal of Arthroscopic & Related Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2022.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier on behalf of the Arthroscopy Association of North America","name":"copyright","label":"Copyright"}]}}