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The primary outcomes were postoperative pain intensity at 2 hours and 24 hours. Secondary outcomes included the time to first analgesic request, number of patients requiring supplementary analgesics and side effects. We estimated summary standardized mean differences (SMDs) or odds ratios with 95% credible intervals (95% CrIs) using Bayesian network meta\u2010analysis with random effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 78 randomized controlled trials comprising 4,425 participants were included. Compared with placebo, magnesium plus bupivacaine was most likely to be effective in relieving pain at both 2\u2010hour (SMD\u00a0= \u20133.81, 95% CrI \u20135.28 to \u20132.35) and 24\u2010hour after surgery (SMD\u00a0= \u20132.81, 95% CrI: \u20134.29 to \u20101.30). Following was morphine plus bupivacaine (2\u2010hour: SMD\u00a0= \u20132.19, 95% CrI \u20133.05 to \u20131.31; 24\u2010hour: SMD\u00a0= \u20131.44, 95% CrI \u20132.14 to \u20130.73) and bupivacaine alone (2\u2010hour: SMD\u00a0= \u20131.66, 95% CrI \u20132.33 to \u20130.98; 24\u2010hour: SMD\u00a0= \u20130.67, 95% CrI \u20131.22 to \u20130.07); ropivacaine alone and magnesium alone were not effective on pain relief. The interval time to first analgesic request was significantly extended compared with placebo except for ropivacaine alone and magnesium alone. The number of patients requiring supplementary analgesics was reduced in all groups except ropivacaine alone. No statistically significant difference was found between any studied analgesics or placebo with regard to side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Of 6 common postoperative intra\u2010articular analgesics, magnesium plus bupivacaine provides the most effective pain relief without increasing short\u2010term side effects after knee arthroscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, meta\u2010analysis of Level I and II studies.<\/jats:p>\n                  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