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Clinical characteristics, re\u2010tear rates, range of motion (ROM), and patient\u2010reported outcomes (PRO) data were collected. Interventions were compared via arm\u2010based Bayesian network meta\u2010analysis in a random\u2010effects model. Interventions were ranked for each domain (re\u2010tear risk, pain, ROM, and PROs) via surface under the cumulative ranking curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 18 studies comprising 2046 shoulders (47% females, mean age 61 \u00b1 3 years, mean follow\u2010up 21 \u00b1 5 months) were included. Interventions that ranked highest for minimizing re\u2010tear risk included arthroscopic single\u2010row repair (A+SR) or double\u2010row repair (A+DR) with or without platelet\u2010rich plasma (PRP). Open repair and A+SR repair with acromioplasty (ACP) ranked highest for pain relief. Interventions that ranked highest for ROM improvement included open repair, PT, and A+DR with or without ACP. Interventions that ranked highest for PROs included arthroscopic footprint microfracture with or without SR, open repair, and A+SR with or without ACP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on a network meta\u2010analysis of level 1 studies, arthroscopic rotator cuff repair with a SR or DR construct demonstrates similar retear rates, PROs, and clinical outcomes. The highest\u2010ranking treatment for minimizing retears was arthroscopic repair with DR constructs and PRP augmentation, although open repair and arthroscopic SR remain reliable options with excellent clinical outcomes. Addition of PRP to DR constructs trended toward a 56% decreased risk of retear as compared to DR repair alone. Although no single treatment emerged superior, several interventions offered excellent clinical improvements in pain, ROM, and PROs that exceeded minimal clinically important difference thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of evidence<\/jats:title>\n                    <jats:p>I, systematic review and meta\u2010analysis of level I studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2022.03.014","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T03:04:06Z","timestamp":1647918246000},"page":"2714-2729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Double\u2010Row Repair With Platelet\u2010Rich Plasma Optimizes Retear Rates After Small to Medium Full\u2010Thickness Rotator Cuff Repair: A Systematic Review and Network Meta\u2010analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"38","author":[{"given":"Ophelie","family":"Lavoie\u2010Gagne","sequence":"first","affiliation":[{"name":"Harvard Combined Orthopaedic Residency Program Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Fury","sequence":"additional","affiliation":[{"name":"Harvard Combined Orthopaedic Residency Program Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Mehta","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Harkin","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Harvard Combined Orthopaedic Residency Program Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse J.","family":"Berlinberg","sequence":"additional","affiliation":[{"name":"Midwest Orthopedics at Rush Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Parvaresh","sequence":"additional","affiliation":[{"name":"Orthopaedic Specialty Institute Orange California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Forsythe","sequence":"additional","affiliation":[{"name":"Midwest Orthopedics at Rush Chicago Illinois 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