{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:32:31Z","timestamp":1784849551731,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","award":["14-2020-0001"],"award-info":[{"award-number":["14-2020-0001"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","arthroscopyjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the effect of recombinant human parathyroid hormone (rhPTH) biocomposite on bone\u2010to\u2010tendon interface (BTI) healing for surgical repair of a chronic rotator cuff tear (RCT) model of rabbit, focusing on genetic, histologic, biomechanical and micro\u2013computed tomography (CT) evaluations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010four rabbits were equally assigned to the 4 groups: saline injection (group A), nanofiber sheet\u00a0alone (group B), rhPTH\u2010soaked nanofiber sheet (nanofiber sheet was soaked with rhPTH, group C), and rhPTH biocomposite (rhPTH permeated the nanofiber sheet by coaxial electrospinning, group D). The release kinetics of rhPTH (groups C and D) was examined for 6 weeks in\u00a0vitro. Nanofiber scaffolds were implanted on the surface of the repair site 6 weeks after the induction of chronic RCT. Genetic and histologic analyses were conducted 4 weeks after surgery. Furthermore, genetic, histologic, biomechanical, micro\u2010CT, and serologic analyses were performed 12 weeks after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In\u00a0vivo, group D showed the highest collagen type I alpha 1 (COL1A1), collagen type III alpha 1 (COL3A1), and bone morphogenetic protein 2 (BMP\u20102) messenger RNA (mRNA) expression levels (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) 4 weeks after surgery; however, there were no differences between groups at 12 weeks postsurgery. After 12 weeks postsurgery, group D showed better collagen fiber continuity and orientation, denser collagen fibers, more mature bone\u2010to\u2010tendon junction, and greater fibrocartilage layer formation compared with the other groups (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05). Furthermore, group D showed the highest load\u2010to\u2010failure rate (28.9 \u00b1 2.0 N\/kg for group A, 30.1 \u00b1 3.3 N\/kg for group B, 39.7 \u00b1 2.7 N\/kg for group C, and 48.2 \u00b1 4.5 N\/kg for group D,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) and micro\u2010CT outcomes, including bone and tissue mineral density, and bone volume\/total volume rate (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) at 12 weeks postsurgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In comparison to rhPTH\u2010soaked nanofiber sheet and the other control groups, rhPTH biocomposite effectively accelerated BTI healing by enhancing the mRNA expression levels of COL1A1, COL3A1, and BMP\u20102 at an early stage and achieving tenogenesis, chondrogenesis, and osteogenesis at 12 weeks after surgical repair of a chronic RCT model of rabbit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>The present study might be a transitional study to demonstrate the efficacy of rhPTH biocomposites on BTI healing for surgical repair of chronic RCTs as an adaptable polymer biomaterial in humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2023.09.034","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T21:40:37Z","timestamp":1700689237000},"page":"1093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Recombinant Human Parathyroid Hormone Biocomposite Promotes Bone\u2010to\u2010Tendon Interface Healing by Enhancing Tenogenesis, Chondrogenesis, and Osteogenesis in a Rabbit Model of Chronic Rotator Cuff Tears"],"prefix":"10.1002","volume":"40","author":[{"given":"Jian","family":"Han","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery The First People's Hospital of Huzhou First Affiliated Hospital of Huzhou University Huzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng Chen","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Seoul National University College of Medicine Seoul National University Bundang Hospital Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Jang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Seoul National University College of Medicine Seoul National University Bundang Hospital Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Min","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery KyungHee University Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Seo","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Pusan National University Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Jun","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery School of Medicine Ajou University Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk\u2010Hee","family":"Park","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Pusan National University Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Han","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Seoul National University College of Medicine Seoul National University Bundang Hospital 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