{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:57:48Z","timestamp":1784775468845,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010669","name":"H2020 LEIT Information and Communication Technologies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF-2022R1A2C1005374"],"award-info":[{"award-number":["NRF-2022R1A2C1005374"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","arthroscopyjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the effects of topical tranexamic acid (TXA) administration on tendon adhesions, shoulder range of motion (ROM), and tendon healing in an acute rotator cuff repair rat model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 20 Sprague Dawley rats were used. Tendon adhesion, ROM, and biomechanical and histological analysis of tendon\u2010bone healing was conducted at 3 and 6 weeks after surgery. The rats underwent rotator cuff repair surgery on both shoulders and were administered TXA via subacromial injections. The tendon adhesion was evaluated macroscopically and histologically. Biomechanical tendon healing was measured using a universal testing machine, and histological analysis was quantified by H&amp;E, Masson\u2019s trichrome, and picrosirius red staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 3 weeks after surgery, the adhesion score was significantly lower in the TXA group (2.10 \u00b1 0.32) than in the control group (2.70 \u00b1 0.48) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .005), but there was no significant difference between the 2 groups at 6 weeks. Regarding ROM, compared with the control group, the TXA group showed significantly higher external rotation (36.35\u00b0 \u00b1 4.52\u00b0 vs 28.42\u00b0 \u00b1 4.66\u00b0,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) and internal rotation (45.35\u00b0 \u00b1 9.36\u00b0 vs 38.94\u00b0 \u00b1 5.23\u00b0,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .013) 3 weeks after surgery. However, at 6 weeks, there were no significant differences in external and internal rotation between the 2 groups. In the biomechanical analysis, no significant differences in gross examination (3 weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .175, 6 weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .295), load to failure (3 weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .117, 6 weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .295), or ultimate stress (3 weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .602, 6 weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .917) were noted between the 2 groups 3 and 6 weeks after surgery. In the histological analysis of tendon healing, no significant differences in the total score (3 weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .323, 6 weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0= .572) were found between the 2 groups 3 and 6 weeks after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Topical TXA administration showed a beneficial effect in reducing tendon adhesions and improving ROM 3 weeks postoperatively and had no effect at 6 weeks. This suggests that additional intervention with TXA may be useful in achieving long\u2010term improvement in shoulder stiffness. Additionally, TXA may increase tissue ground substance accumulation in the late postoperative period but does not adversely affect tendon\u2010bone interface healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>The use of TXA after rotator cuff repair has no effect on tendon\u2010bone interface healing in clinical practice and can improve shoulder stiffness in the early postoperative period. Additional research on the long\u2010term effects is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2024.01.027","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T12:23:06Z","timestamp":1706876586000},"page":"2174-2183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tranexamic Acid Can Reduce Early Tendon Adhesions After Rotator Cuff Repair and Is Not Detrimental to Tendon\u2010Bone Healing: A Comparative Animal Model Study"],"prefix":"10.1002","volume":"40","author":[{"given":"Jong Pil","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene Jae Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kyungpook National University Hospital Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bum\u2010Jin","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Kyungpook National University Hospital Daegu Republic of 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