{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:44:27Z","timestamp":1785285867980,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","arthroscopyjournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of marrow stimulation (MS) versus biphasic scaffold loaded with autologous cartilage (scaffold) in treating focal osteochondral lesions of the knee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 54 patients with symptomatic focal chondral or osteochondral lesion in the knee were randomized to either the scaffold group or the MS group. International Knee Documentation Committee subjective score, the Knee Injury Osteoarthritis Outcome Score, and magnetic resonance imaging (MRI) were assessed preoperatively and at 1 and 2 years after operation to compare treatment outcomes. Biopsy and second\u2010look arthroscopy were performed at 1 year postoperatively for consenting patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 27 patients (mean age 31.33 \u00b1 10.95 years) in the scaffold group, and 27 patients (31.74 \u00b1 11.44) in the MS group. The scaffold group and the MS group both included 23 patients with lesions \u226412.5\u00a0\u00d7 12.5 mm\n                      <jats:sup>2<\/jats:sup>\n                      mm in size. In addition, each group had 4 patients with lesions between than 12.5\u00a0\u00d7 12.5 mm\n                      <jats:sup>2<\/jats:sup>\n                      and \u226412.5\u00a0\u00d7 25 mm\n                      <jats:sup>2<\/jats:sup>\n                      . Both interventions achieved significant improvement in clinical outcome scores at 2 years. The scaffold group had greater International Knee Documentation Committee score than the MS group at 2 years (93.85 \u00b1 9.55 vs 92.11 \u00b1 9.84) and in the Symptoms\/Stiffness and Sport\/Recreation subscales of Knee Injury Osteoarthritis Outcome Score at 2 years (96.57 \u00b1 5.97 vs 93.57 \u00b1 6.52,\n                      <jats:italic>P &lt;<\/jats:italic>\n                      .05) and (90.2 \u00b1 17.76 vs 82.8 \u00b1 16.08,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of biphasic scaffold loaded with autologous cartilage in treating focal osteochondral lesions demonstrates superior clinical outcomes and better cartilage refill on magnetic resonance imaging at the 2\u2010year follow\u2010up compared to marrow stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level I, Randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2024.04.016","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T21:42:35Z","timestamp":1715031755000},"page":"688-699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biphasic Scaffold Loaded With Autologous Cartilage Yields Better Clinical Outcome and Magnetic Resonance Imaging Filling Compared With Marrow Stimulation for Focal Osteochondral Lesions in the Knee"],"prefix":"10.1002","volume":"41","author":[{"given":"Chao\u2010Ping","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopedics Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Department of Health Services Administration China Medical University Taichung Taiwan"},{"name":"Department of Acupressure Technology Jen\u2010Teh Junior College of Medicine Nursing and Management Miaoli Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Wei","family":"Weng","sequence":"additional","affiliation":[{"name":"International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan"},{"name":"Department of Orthopaedics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Department of Orthopedics Shuang Ho Hospital Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun\u2010Tsan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine National Chung\u2010Hsing University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Yu","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Taichung Armed Forces General Hospital Taichung Taiwan"},{"name":"School of Medicine National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Jen","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"480","article-title":"Focal cartilage defects within the medial knee compartment. 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Published by Elsevier Inc. on behalf of the Arthroscopy Association of North America.","name":"copyright","label":"Copyright"}]}}