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The secondary purpose was to compare short\u2010term functional outcomes between the 2 protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A power analysis demonstrated that 43 patients were required. In this randomized control trial, patients with meniscal pathology undergoing arthroscopic meniscus surgery were included. Group 1 received oxycodone\u2010acetaminophen alone. Group 2 received 1 dose of intravenous ketorolac intraoperatively, oral ketorolac upon discharge, and \u201crescue\u201d oxycodone\u2010acetaminophen. Patients recorded the number of opioid tablets consumed and visual analog pain scale (VAS) scores 3 times per day for 5 days postoperatively. Opioids were converted to morphine milligram equivalents (MMEs). VAS, Lysholm Knee Scoring Scale, and Knee injury and Osteoarthritis Outcome Score were obtained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight patients were randomized. There were 25 patients in the control group and 23 patients in the ketorolac group. The mean (SD) age was 47.9 (14.3) years. Fifty\u2010two percent (n = 25) of the population were female. Three patients (6.3%) underwent meniscal repair. During the first 5 days postoperatively, the mean VAS score (\u03b2 = \u201313.2, SE = 5.97,\n                      <jats:italic>P<\/jats:italic>\n                      = .029) and the MMEs consumed were significantly lower (\u03b2 = \u20134.7, SE = 1.93,\n                      <jats:italic>P<\/jats:italic>\n                      = .015) per time point in the ketorolac group relative to the control group. The control group had better Lysholm Knee Scoring Scale (mean [SD] 80.6 [18.5] vs 65 [21.5],\n                      <jats:italic>P<\/jats:italic>\n                      = .016) and Knee injury and Osteoarthritis Outcome Score (mean [SD], 74.1 [16.7] vs 61.9 [18.6],\n                      <jats:italic>P<\/jats:italic>\n                      = .029) scores at 6 weeks. There were no significant differences in the rates of side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An opioid\u2010sparing pain protocol of intravenous and oral ketorolac is associated with significant reductions in VAS scores and MME consumption in the first 5 days after arthroscopic meniscus surgery. There were significant differences in patient\u2010reported outcomes at final follow\u2010up, favoring the control group. There were no significant differences in adverse reactions and side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, prospective randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2024.08.035","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T10:23:37Z","timestamp":1725618217000},"page":"1989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Opioid\u2010Sparing Pain Protocol of Intravenous and Oral Ketorolac Reduces Opioid Consumption and Pain Levels After Arthroscopic Meniscus Surgery: A Prospective, Randomized Controlled Trial"],"prefix":"10.1002","volume":"41","author":[{"given":"John T.","family":"Strony","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery University Hospitals Cleveland Medical Center Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Mengers","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University Hospitals Cleveland Medical Center Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmanan","family":"Sivasundaram","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University Hospitals Cleveland Medical Center Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Sinkler","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University Hospitals Cleveland Medical Center Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenya","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdus","family":"Sattar","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University School of Medicine Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Salata","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University Hospitals Cleveland Medical Center Cleveland Ohio U.S.A."},{"name":"Case Western Reserve University School of Medicine Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Voos","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University Hospitals Cleveland Medical Center Cleveland Ohio U.S.A."},{"name":"Case Western Reserve University School of Medicine Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Karns","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University Hospitals Cleveland Medical Center Cleveland Ohio U.S.A."},{"name":"Case Western Reserve University School of Medicine Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6911a4"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.109028"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11524-020-00486-y"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.366"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k3207"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1508490"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-14-00163"},{"key":"e_1_2_4_9_2","volume-title":"The CBHSQ Report. 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