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Only recently have orthopaedic surgeons begun to explore whether these medications might reduce or prevent postoperative joint stiffness. The relationship between orthopaedic surgeons and fibrosis is more complicated. When immune cell recruitment, fibroblast activation, collagen deposition, and extracellular matrix remodeling occurs in a fashion we like, we call it \u201chealing.\u201d When it occurs in a fashion we dislike, we call it \u201cfibrosis.\u201d There is growing interest in chemoprophylaxis against postoperative fibrosis after shoulder surgery, arthroplasty, and hip arthroscopy. Limited studies examining the issue to date have produced conflicting results. Mining large databases for answers is unlikely to produce clinically meaningful results, and specific trials will be necessary to answer the question. Future research should not ignore the fact that medications other than losartan function in similar ways\u2014and may also have antifibrotic effects.<\/jats:p>","DOI":"10.1016\/j.arthro.2024.12.037","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T19:15:32Z","timestamp":1736190932000},"page":"2222-2223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Editorial Commentary:<\/i>\n                    Losartan May Prevent Clinically Significant Postoperative Fibrosis, but Large Database Studies May Not Provide an Answer"],"prefix":"10.1002","volume":"41","author":[{"given":"George C.","family":"Balazs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-1555-5"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2024.11.084"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asmr.2021.10.031"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asmr.2023.05.005"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2023.10.015"},{"key":"e_1_2_3_7_2","first-page":"671","article-title":"ACE Inhibitor and ARB utilization and expenditures in the Medicaid fee\u2010for\u2010service program from 1991 to 2008","volume":"16","author":"Bian B.","year":"2010","journal-title":"J Manag Care Pharm"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806325000039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806325000039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2024.12.037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2024.12.037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2024.12.037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:21:43Z","timestamp":1773566503000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2024.12.037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1016\/j.arthro.2024.12.037"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2024.12.037","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Editorial Commentary: Losartan May Prevent Clinically Significant Postoperative Fibrosis, but Large Database Studies May Not Provide an Answer","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy: The Journal of Arthroscopic & Related Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2024.12.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2024.11.084","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of the Arthroscopy Association of North America","name":"copyright","label":"Copyright"}]}}