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In the in vivo experiment, 48 rabbits were randomly allocated into 3 groups. To create chronic RCT models, transected tendons were left untreated for 6 weeks and then were repaired in a transosseous manner. Different materials were injected into repair site according to the allocated group (group A: saline, group B: fibrin glue only, group C: DF\u2010Ex with fibrin glue; n = 16 for each). Genetic and immunofluorescence analyses were conducted at 4 weeks post\u2010surgery. Furthermore, genetic, histologic, and biomechanical analyses were conducted at 12 weeks post\u2010surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In vitro analyses revealed the exosomal marker proteins CD9, CD63, and ALIX were positively expressed in DF\u2010Ex, whereas negative control Calnexin was nearly absent. In vivo analyses showed that group C had the highest mRNA expression levels of COL1A1, COL3A1, and ACAN among all groups (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001,\n                      <jats:italic>P<\/jats:italic>\n                      = .007, and\n                      <jats:italic>P<\/jats:italic>\n                      = .002, respectively) at 4 weeks postsurgery. Meanwhile, there were more preliminary fibrocartilaginous matrix (aggrecan+\/collagen II+) formation in group C. At 12 weeks postsurgery, group C had better collagen fiber continuity and orientation, denser collagen fibers, more mature bone\u2010to\u2010tendon junction, and greater fibrocartilage layer formation compared with the other groups (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05). Moreover, group C also had greater load\u2010to\u2010failure value (53.3 \u00b1 6.1 N\/kg,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Topical DF\u2010Ex administration effectively promoted BTI healing by upregulating the COL1A1, COL3A1, and ACAN mRNA expression levels at an early stage and enhancing the structural and biomechanical properties at 12 weeks after surgical repair of a chronic RCT model of rabbit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>The study could be a transitional study to investigate the efficacy of DF\u2010Ex on BTI healing for surgical repair of chronic RCTs as a powerful biological agent in humans.<\/jats:p>\n        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