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However, regrowth of healthy hyaline cartilage within diseased areas remains elusive. Recent research proposes allogenic human umbilical cord blood\u2212derived mesenchymal stem cells as another cell\u2010based biologics approach. A benefit of this technique would be the availability of viable \u201coff\u2010the\u2010shelf\u201d undifferentiated cells, obviating the need for bone marrow aspiration or adipose cell harvest. Findings included improved Magnetic Resonance Observation Cartilage Repair Tissue, which correlated negatively with defect size and improved patient\u2010reported outcomes in terms of symptom reduction. High tibial osteotomy, which is known to result in improved outcomes in patients with cartilage degeneration (and malalignnment), is a confounder. This illustrates the importance of evaluating and treating the whole knee, and the whole patient, including extremity alignment, meniscal status, stability, body mass, and the synovial fluid environment. Cell\u2010based treatments may be a piece of that puzzle. In addition to indeterminate outcomes and indications, barriers to adoption include cost and access.<\/jats:p>","DOI":"10.1016\/j.arthro.2025.01.058","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T03:02:28Z","timestamp":1738897348000},"page":"2898-2899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Editorial Commentary<\/i>\n                    : Biologics for Knee Cartilage Regeneration Show Modest Symptom\u2010Reducing Efficacy"],"prefix":"10.1002","volume":"41","author":[{"given":"Mina","family":"Entessari","sequence":"first","affiliation":[{"name":"Wake Forest University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Trasolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/10225536231162829"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-023-07373-4"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24379"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-020-04838-w"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2024.11.083"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806325000763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806325000763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2025.01.058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2025.01.058","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2025.01.058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:29:32Z","timestamp":1773566972000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2025.01.058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":5,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1016\/j.arthro.2025.01.058"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2025.01.058","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Editorial Commentary: Biologics for Knee Cartilage Regeneration Show Modest Symptom-Reducing Efficacy","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy: The Journal of Arthroscopic & Related Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2025.01.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2024.11.083","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the Arthroscopy Association of North America","name":"copyright","label":"Copyright"}]}}