{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:41:53Z","timestamp":1793378513455,"version":"4.5.0"},"reference-count":70,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate complications of platelet\u2010rich plasma (PRP) injections for knee osteoarthritis (OA) compared with other injected substances including hyaluronic acid (HA), corticosteroids, and placebo saline solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PubMed, Embase, Web of Science, and Cochrane databases were searched to identify randomized controlled trials (RCTs) comparing PRP with another injectable treatment for knee OA with documented complications. Studies not mentioning complications or using PRP during surgery were excluded. Complications were pooled to determine the overall complication rate and the number needed to harm (NNH). Subgroup analyses were performed for studies comparing PRP with HA, corticosteroids, and placebo saline solution using DerSimonian\u2010Laird random\u2010effects models displaying odds ratios (ORs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four RCTs were identified, with 2,751 total patients, 1,318 of whom received PRP injections. A total of 246 complications occurred in the PRP group versus 131 in the comparison cohort (18.66% vs 9.14%,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01). The NNH was 11. Subgroup analysis showed no difference in the odds of complications when PRP was compared with HA (OR = 1.33,\n                      <jats:italic>P<\/jats:italic>\n                      = .22,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.0%) and corticosteroids (OR = 3.07,\n                      <jats:italic>P<\/jats:italic>\n                      = .35,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 63.49%) but showed significantly more complications when compared with placebo (OR = 4.88,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.00%). Only 1 patient reported severe pain; all other complications were described as moderate or mild and self\u2010limiting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of PRP for knee OA is not innocuous, with a significantly higher rate of complications compared with placebo. However, most complications were reported as mild to moderate, and the odds of complications are similar to those of HA or corticosteroid injections. Compared with all other injectables, the NNH for PRP is 11, which is important for physicians to consider prior to PRP therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level II, meta\u2010analysis of Level I and II randomized control trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2025.05.018","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T11:22:27Z","timestamp":1747826547000},"page":"4789-4803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Complications of Platelet\u2010Rich Plasma Injection for Knee Osteoarthritis Are Similar to Those of Corticosteroids and Hyaluronic Acid but Are Significantly Greater Than Those of Placebo Injections: A Meta\u2010analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"41","author":[{"given":"Stephen P.","family":"Fucaloro","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Tufts Medical Center Boston Massachusetts U.S.A."},{"name":"Tufts University School of Medicine Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Bragg","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Tufts Medical Center Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makeda","family":"Berhane","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Mulvey","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Krivicich","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Tufts Medical Center Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Zink","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Tufts Medical Center Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Salzler","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Tufts Medical Center Boston Massachusetts U.S.A."},{"name":"Tufts University School of Medicine Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.07.017"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207794"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-21-01233"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019388"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211062243"},{"key":"e_1_2_3_7_1","first-page":"e24503","article-title":"Role and effectiveness of intra\u2010articular injection of hyaluronic acid in the treatment of knee osteoarthritis: A systematic review","volume":"14","author":"Chavda S.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-024-05442-y"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1204144"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06925-6"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671211011948"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-017-0521-3"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.11.052"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.12.006"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-18"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58081028"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-021-04230-2"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-01753-z"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10050991"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-022-06887-7"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57111193"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-3985-6"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2017.11.035"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.46582\/jsrm.1202011"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-0920-3"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2013.07.264"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512471299"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520986867"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.10.013"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S210715"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S147757"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000874"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215517724193"},{"key":"e_1_2_3_36_1","first-page":"232596711668938","article-title":"Platelet\u2010rich plasma injections for advanced knee osteoarthritis: A prospective, randomized, double\u2010blinded clinical trial","volume":"5","author":"Joshi Jubert N.","year":"2017","journal-title":"Orthop J Sports Med"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515624678"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512461902"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19415"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000001067"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2023.03.002"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2016.09.024"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515580787"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.03.041"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.trap.2007.05.006"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.01.009"},{"key":"e_1_2_3_48_1","unstructured":"Food and Drug Administration.What is a serious adverse event?https:\/\/www.fda.gov\/safety\/reporting\u2010serious\u2010problems\u2010fda\/what\u2010serious\u2010adverse\u2010eventPublished May 15 2024. Accessed February 11 2025."},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz011"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-01919-9"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211064303"},{"key":"e_1_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.02.045"},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-021-06659-9"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.04.015"},{"key":"e_1_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk6010015"},{"key":"e_1_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/2374373519893199"},{"key":"e_1_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.341"},{"key":"e_1_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-10-200411160-00009"},{"key":"e_1_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518814532"},{"key":"e_1_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10030684"},{"key":"e_1_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516665809"},{"key":"e_1_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.06.035"},{"key":"e_1_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671221120678"},{"key":"e_1_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00092-1"},{"key":"e_1_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02594-9"},{"key":"e_1_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13948"},{"key":"e_1_2_3_67_1","first-page":"953","article-title":"One injection of platelet\u2010rich plasma associated to a submaximal eccentric protocol to treat chronic jumper's knee","volume":"55","author":"Kaux J.F.","year":"2015","journal-title":"J Sports Med Phys Fitness"},{"key":"e_1_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014702"},{"key":"e_1_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2019.1584329"},{"key":"e_1_2_3_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.077131"},{"key":"e_1_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2022-0216"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806325003731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806325003731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2025.05.018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2025.05.018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2025.05.018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:17:59Z","timestamp":1773566279000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2025.05.018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":70,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1016\/j.arthro.2025.05.018"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2025.05.018","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complications of Platelet-Rich Plasma Injection for Knee Osteoarthritis Are Similar to Those of Corticosteroids and Hyaluronic Acid but Are Significantly Greater Than Those of Placebo Injections: A Meta-analysis of Randomized Controlled Trials","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy: The Journal of Arthroscopic & Related Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2025.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the Arthroscopy Association of North America","name":"copyright","label":"Copyright"}]}}