{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:23:12Z","timestamp":1792430592858,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014413","name":"Ajinomoto Animal Nutrition North America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019967","name":"JRF Ortho","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019967","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["arthroscopyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To perform a prospective, double\u2010blind, randomized controlled trial to assess differences in integration and patient\u2010reported outcomes metrics (PROMs) of osteochondral allograft transplantation with and without bone marrow aspirate concentrate (BMAC) augmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients (n = 36) undergoing osteochondral allograft transplantation of the knee were consented and enrolled in this prospective study. They were randomized to either iliac crest BMAC or sham incision groups and blinded to their allocation. Computerized tomography (CT) scans of the knee were obtained at 6 months postoperatively after the index transplantation and graded by the semiquantitative assessment CT osteochondral allograft system. PROMs, including the International Knee Documentation Committee and Knee injury and Osteoarthritis Outcome Score\u2013Joint Replacement, were obtained at 6 months, 1 year, and 2 years postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On 6\u2010month postoperative CT scans, patients receiving BMAC\u2010treated grafts were more likely to have small cystic changes (\n                      <jats:italic>P<\/jats:italic>\n                      = .01), with an associated trend toward reduction in large cyst formation (\n                      <jats:italic>P<\/jats:italic>\n                      = .06), but equal osseous integration, graft signal density, and presence of discernible clefts and intra\u2010articular fragments. The BMAC group was less likely to undergo subsequent surgery for graft debridement or revision (5.3% vs 35.3%;\n                      <jats:italic>P<\/jats:italic>\n                      = .02). There were no significant differences in PROMs between the 2 groups preoperatively or postoperatively at 6 months, 1 year, or 2 years. Patients receiving BMAC trended toward a higher rate of achievement of Knee Documentation Committee and Knee injury and Osteoarthritis Outcome Score\u2013Joint Replacement minimal clinically important difference (88% vs 55%;\n                      <jats:italic>P<\/jats:italic>\n                      = .076).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients receiving BMAC\u2010treated grafts were more likely to have small cystic changes and were less likely to undergo subsequent surgery for persistent or new symptoms after the index procedure. No difference in postoperative PROMs was shown at the 6\u2010month, 1\u2010year, and 2\u2010year follow\u2010ups between the 2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level I, prospective, randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.arthro.2025.05.024","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T21:42:09Z","timestamp":1749159729000},"page":"4664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bone Marrow Aspirate Concentrate May Decrease Reoperation in Osteochondral Allograft Transplantation: A Prospective, Randomized, Double\u2010Blind Investigation"],"prefix":"10.1002","volume":"41","author":[{"given":"Adam B.","family":"Yanke","sequence":"first","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navya","family":"Dandu","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."},{"name":"Alleghany General Hospital Pittsburgh Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake M.","family":"Bodendorfer","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Trasolini","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."},{"name":"Wake Forest Baptist Health Winston\u2010Salem North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Hevesi","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."},{"name":"Mayo Clinic Rochester Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan J.","family":"Elias","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Haneberg","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem Y.","family":"Darwish","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athan","family":"Zavras","sequence":"additional","affiliation":[{"name":"Alleghany General Hospital Pittsburgh Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Forsythe","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Cole","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181d9eea0"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509352157"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS\u2010D\u201015\u201000447"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465231205309"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241260271"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211037233"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0095399703258614"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511435780"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518814236"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465251315492"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671231199418"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241238466"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671241264856"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516676072"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2016.04.020"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.12.002"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465231196156"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2025.03.063"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000165845.21735.05"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198808000-00035"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22998"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072040-00016"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516629434"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241268969"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603517741169"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967115625481"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603514563597"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510392023"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.5604\/15093492.1012405"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010023\u201007651\u20101"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/10711007221104069"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101603800"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518813915"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517715725"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.03.033"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967119893634"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.otsm.2018.06.007"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2023.07.056"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010020\u201004927\u2010w"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603511410418"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178\u2010012\u20109132\u20100"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1063\u20104584(03)00006\u20102"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2018.06.047"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517739606"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010017\u20103597\u20109"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519832003"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546519851098"}],"container-title":["Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806325004025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806325004025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2025.05.024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2025.05.024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2025.05.024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:17:37Z","timestamp":1773566257000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2025.05.024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1016\/j.arthro.2025.05.024"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2025.05.024","archive":["Portico"],"relation":{},"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone Marrow Aspirate Concentrate May Decrease Reoperation in Osteochondral Allograft Transplantation: A Prospective, Randomized, Double-Blind Investigation","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy: The Journal of Arthroscopic & Related Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arthro.2025.05.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the Arthroscopy Association of North America","name":"copyright","label":"Copyright"}]}}