{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:24:31Z","timestamp":1783707871397,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007536","name":"Aesculap Implant Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007536","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007307","name":"Arthrex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007307","name":"Arthrex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019967","name":"JRF Ortho","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019967","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["arthroscopysportsmedicineandrehabilitation.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Arthroscopy, Sports Medicine, and Rehabil."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the utility of implanting biointegrative cannulated nails in a rafter arrangement within the tibial plateau or femoral condyle for treatment of subchondral insufficiency of the knee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were followed for 12 months after surgical intervention for subchondral insufficiency using biointegrative, fiber\u2010reinforced fixation nails. Patients (ages 18\u201075 years) had moderate knee pain for at least 6 months, unicompartmental Kellgren\u2010Lawrence grade 2\u20103 and bone marrow lesions confirmed on magnetic resonance imaging (MRI). Comparison of baseline and postoperative Knee Injury and Osteoarthritis Outcome Score (KOOS) was the primary outcome measure. Other patient\u2010reported outcome measures included International Knee Documentation Committee (IKDC) and Patient\u2010reported Outcomes Measurement Information System (PROMIS). Minimal clinically important difference was calculated for each PRO. Calculated bone marrow lesion volumes measured on MRI were compared from baseline to 12 months postoperative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine patients were included, with follow\u2010up of 12 \u00b1 1 months. Significant improvements were seen in KOOS, IKDC, PROMIS, and Veterans RAND 12\u2010Item Health Survey (VR\u201012). The average change in patient\u2010reported outcome measures at 12 months were KOOS (19.68,\n                      <jats:italic>P<\/jats:italic>\n                      = .008), IKDC (28.99,\n                      <jats:italic>P<\/jats:italic>\n                      = .004), PROMIS Pain Interference (10.35,\n                      <jats:italic>P<\/jats:italic>\n                      = .008), PROMIS Physical Function (11.06,\n                      <jats:italic>P<\/jats:italic>\n                      = .008), and VR\u201012 Physical (16.14,\n                      <jats:italic>P<\/jats:italic>\n                      = .008). Minimal clinically important difference was achieved in 89% of patients for KOOS, 100% for IKDC, 87.5% for PROMIS Pain Interference and Physical Function, and 62.5% for VR\u201012 Physical. The average decrease in subchondral lesion size measured on MRI did not reach statistical significance (\n                      <jats:italic>P<\/jats:italic>\n                      = .064). All patients reported successful return to sport, with no reoperations or implant failures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Biointegrative fixation nail raftering for treatment of subchondral insufficiency of the knee resulted in improved patient\u2010reported pain and functionality at 12\u2010month follow\u2010up in the setting of early\u2010to\u2010moderate osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level IV, therapeutic case series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.asmr.2025.101105","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T19:30:24Z","timestamp":1739215824000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biointegrative Nail Raftering Improves Pain and Function in Patients With Subchondral Insufficiency of the Knee"],"prefix":"10.1002","volume":"7","author":[{"given":"Alexander C.","family":"Weissman","sequence":"first","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen A.","family":"Yazdi","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared P.","family":"Sachs","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Muth","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Bi","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Gilat","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Cole","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100587"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703856114"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509352157"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21148"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21474"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B12.18140"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1818-0"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200302000-00035"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21290"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.217"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13233532"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14978"},{"key":"e_1_2_3_14_2","unstructured":"Giordano V Pires RE Kojima KE Fischer ST Giannoudis PV. Subchondral rafting plate for the treatment of fragmented articular central depression tibial plateau fracture patterns: Case series and technical illustration.Cureus13:e12740."},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2014.11.002"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-200009000-00002"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2022.06.013"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/2473011420966311"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-019-03245-6"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520988164"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603518812552"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43019-023-00200-7"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/23259671231163528"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2022.10.010"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1529-9430(02)00412-6"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10195-020-00547-7"}],"container-title":["Arthroscopy, Sports Medicine, and Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666061X25000318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666061X25000318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.asmr.2025.101105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.asmr.2025.101105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.asmr.2025.101105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:14:35Z","timestamp":1773566075000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.asmr.2025.101105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1016\/j.asmr.2025.101105"],"URL":"https:\/\/doi.org\/10.1016\/j.asmr.2025.101105","archive":["Portico"],"relation":{},"ISSN":["2666-061X","2666-061X"],"issn-type":[{"value":"2666-061X","type":"print"},{"value":"2666-061X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biointegrative Nail Raftering Improves Pain and Function in Patients With Subchondral Insufficiency of the Knee","name":"articletitle","label":"Article Title"},{"value":"Arthroscopy, Sports Medicine, and Rehabilitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.asmr.2025.101105","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the Arthroscopy Association of North America.","name":"copyright","label":"Copyright"}],"article-number":"101105"}}