{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:34:20Z","timestamp":1787891660195,"version":"build-2784847793"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology Clinics of North America"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.atc.2004.05.002","type":"journal-article","created":{"date-parts":[[2005,4,13]],"date-time":"2005-04-13T14:20:31Z","timestamp":1113402031000},"page":"591-606","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["A therapeutic strategy against the shared virulence mechanism utilized by both Yersinia pestis and Pseudomonas aeruginosa"],"prefix":"10.1016","volume":"22","author":[{"given":"Teiji","family":"Sawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine P.","family":"Wiener-Kronish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atc.2004.05.002_BIB1","unstructured":"NIAID biodefense research agenda for CDC category A agents. National Institutes of Health, National Institute of Allergy and Infectious Diseases 2002. p. 1\u201355"},{"key":"10.1016\/j.atc.2004.05.002_BIB2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1046\/j.1365-2958.1997.2731623.x","article-title":"The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells","volume":"23","author":"Cornelis","year":"1997","journal-title":"Mol Microbiol"},{"issue":"16","key":"10.1016\/j.atc.2004.05.002_BIB3","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.1073\/pnas.97.16.8778","article-title":"Molecular and cell biology aspects of plague","volume":"97","author":"Cornelis","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.atc.2004.05.002_BIB4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.200205077","article-title":"Yersinia type III secretion: send in the effectors","volume":"158","author":"Cornelis","year":"2002","journal-title":"J Cell Biol"},{"issue":"2","key":"10.1016\/j.atc.2004.05.002_BIB5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/MMBR.62.2.379-433.1998","article-title":"Type III protein secretion systems in bacterial pathogens of animals and plants","volume":"62","author":"Hueck","year":"1998","journal-title":"Microbiol Mol Biol Rev"},{"issue":"5418","key":"10.1016\/j.atc.2004.05.002_BIB6","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.284.5418.1322","article-title":"Type III secretion machines: bacterial devices for protein delivery into host cells","volume":"284","author":"Galan","year":"1999","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.atc.2004.05.002_BIB7","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/nrm932","article-title":"The Yersinia Ysc-Yop \u2018type III\u2019 weaponry","volume":"3","author":"Cornelis","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.atc.2004.05.002_BIB8","series-title":"Bacterial pathogenesis: a molecular approach","first-page":"260","article-title":"Pseudomonas aeruginosa","author":"Salyers","year":"1994"},{"issue":"10","key":"10.1016\/j.atc.2004.05.002_BIB9","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1128\/IAI.66.10.4611-4623.1998","article-title":"DNA sequencing and analysis of the low-Ca2+ -response plasmid pCD1 of Yersinia pestis KIM5","volume":"66","author":"Perry","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.atc.2004.05.002_BIB10","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1128\/MMBR.62.4.1315-1352.1998","article-title":"The virulence plasmid of Yersinia, an antihost genome","volume":"62","author":"Cornelis","year":"1998","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.atc.2004.05.002_BIB11","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/jb.164.2.704-711.1985","article-title":"Isolation and characterization of Ca2+-blind mutants of Yersinia pestis","volume":"164","author":"Yother","year":"1985","journal-title":"J Bacteriol"},{"key":"10.1016\/j.atc.2004.05.002_BIB12","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.4049\/jimmunol.133.4.2226","article-title":"Roles of V antigen in promoting virulence and immunity in Yersiniae","volume":"133","author":"Une","year":"1984","journal-title":"J Immunol"},{"issue":"15","key":"10.1016\/j.atc.2004.05.002_BIB13","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1093\/emboj\/19.15.3876","article-title":"Supramolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors","volume":"19","author":"Tamano","year":"2000","journal-title":"EMBO J"},{"issue":"8","key":"10.1016\/j.atc.2004.05.002_BIB14","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1073\/pnas.071065798","article-title":"Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells","volume":"98","author":"Hoiczyk","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5363","key":"10.1016\/j.atc.2004.05.002_BIB15","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1126\/science.280.5363.602","article-title":"Supramolecular structure of the Salmonella typhimurium type III protein secretion system","volume":"280","author":"Kubori","year":"1998","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.atc.2004.05.002_BIB16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1574-6968.2001.tb10797.x","article-title":"Bacterial flagella and type III secretion systems","volume":"202","author":"Aizawa","year":"2001","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.atc.2004.05.002_BIB17","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1164\/ajrccm.159.4.9807050","article-title":"The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient [Pt 1]","volume":"159","author":"Heyland","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.atc.2004.05.002_BIB18","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1001\/jama.1995.03530120060042","article-title":"Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units","volume":"274","author":"Brun-Buisson","year":"1995","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.atc.2004.05.002_BIB19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1139\/m85-074","article-title":"The contribution of exoproducts to virulence of Pseudomonas aeruginosa","volume":"31","author":"Nicas","year":"1985","journal-title":"Can J Microbiol"},{"issue":"12","key":"10.1016\/j.atc.2004.05.002_BIB20","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1086\/320737","article-title":"Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections","volume":"183","author":"Roy-Burman","year":"2001","journal-title":"J Infect Dis"},{"issue":"Pt 10","key":"10.1016\/j.atc.2004.05.002_BIB21","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1099\/00221287-147-10-2659","article-title":"Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa","volume":"147","author":"Feltman","year":"2001","journal-title":"Microbiol"},{"issue":"3","key":"10.1016\/j.atc.2004.05.002_BIB22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00003246-200203000-00005","article-title":"Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa","volume":"30","author":"Hauser","year":"2002","journal-title":"Crit Care Med"},{"issue":"11","key":"10.1016\/j.atc.2004.05.002_BIB23","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1086\/379372","article-title":"Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia","volume":"188","author":"Schulert","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.atc.2004.05.002_BIB24","series-title":"Molecular biology of acute lung injury","first-page":"149","article-title":"Mechanisms of lung epithelial cell injury by acute Pseudomonas aeruginosa","author":"Wiener-Kronish","year":"2001"},{"issue":"5 Pt 1","key":"10.1016\/j.atc.2004.05.002_BIB25","first-page":"L551","article-title":"Exoproduct secretions of Pseudomonas aeruginosa strains influence severity of alveolar epithelial injury","volume":"267","author":"Kudoh","year":"1994","journal-title":"Am J Physiol"},{"issue":"2","key":"10.1016\/j.atc.2004.05.002_BIB26","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1128\/iai.65.2.579-586.1997","article-title":"Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S","volume":"65","author":"Fleiszig","year":"1997","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.atc.2004.05.002_BIB27","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/7391","article-title":"Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury","volume":"5","author":"Sawa","year":"1999","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.atc.2004.05.002_BIB28","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1128\/IAI.66.7.3242-3249.1998","article-title":"In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections","volume":"66","author":"Sawa","year":"1998","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.atc.2004.05.002_BIB29","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1365-2958.1997.4891851.x","article-title":"ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury","volume":"25","author":"Finck-Barbancon","year":"1997","journal-title":"Mol Microbiol"},{"issue":"6","key":"10.1016\/j.atc.2004.05.002_BIB30","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1172\/JCI7124","article-title":"Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia","volume":"104","author":"Kurahashi","year":"1999","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.atc.2004.05.002_BIB31","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1046\/j.1365-2958.1997.6251991.x","article-title":"The exoenzyme S regulon of Pseudomonas aeruginosa","volume":"26","author":"Frank","year":"1997","journal-title":"Mol Microbiol"},{"issue":"22","key":"10.1016\/j.atc.2004.05.002_BIB32","doi-asserted-by":"crossref","first-page":"7165","DOI":"10.1128\/jb.179.22.7165-7168.1997","article-title":"Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon","volume":"179","author":"Yahr","year":"1997","journal-title":"J Bacteriol"},{"issue":"6799","key":"10.1016\/j.atc.2004.05.002_BIB33","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/35023079","article-title":"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen","volume":"406","author":"Stover","year":"2000","journal-title":"Nature"},{"issue":"5266","key":"10.1016\/j.atc.2004.05.002_BIB34","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1126\/science.272.5266.1261","article-title":"A shared strategy for virulence","volume":"272","author":"Barinaga","year":"1996","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.atc.2004.05.002_BIB35","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0092-8674(00)81985-6","article-title":"Pathogenicity islands: bacterial evolution in quantum leaps","volume":"87","author":"Groisman","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.atc.2004.05.002_BIB36","first-page":"481","article-title":"The basis of virulence in Pasteurella pestis: an antigen determining virulence","volume":"37","author":"Burrows","year":"1956","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.atc.2004.05.002_BIB37","first-page":"278","article-title":"The effects of loss of virulence determinants on the virulence and immunogenicity of strains of Pasteurella pestis","volume":"39","author":"Burrows","year":"1958","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.atc.2004.05.002_BIB38","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1128\/iai.62.10.4192-4201.1994","article-title":"Passive immunity to Yersiniae mediated by anti-recombinant V antigen and protein A-V antigen fusion peptide","volume":"62","author":"Motin","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.atc.2004.05.002_BIB39","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1128\/iai.63.8.2854-2858.1995","article-title":"Active immunization with recombinant V antigen from Yersinia pesitis protects mice against plague","volume":"63","author":"Leary","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.atc.2004.05.002_BIB40","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0264-410X(98)80110-2","article-title":"Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine","volume":"16","author":"Heath","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.atc.2004.05.002_BIB41","first-page":"225","article-title":"Preparation of monoclonal antibody to V antigen from Yersinia pestis","volume":"12","author":"Sato","year":"1991","journal-title":"Contrib Microbiol Immunol"},{"issue":"10","key":"10.1016\/j.atc.2004.05.002_BIB42","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1128\/jb.171.10.5646-5653.1989","article-title":"Molecular analysis of lcrGVH, the V antigen operon of Yersinia pestis","volume":"171","author":"Price","year":"1989","journal-title":"J Bacteriol"},{"issue":"8","key":"10.1016\/j.atc.2004.05.002_BIB43","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1128\/jb.173.8.2649-2657.1991","article-title":"The Yersinia pestis V antigen is a regulatory protein necessary for Ca2+-dependent growth and maximal expression of low-Ca2+ response virulence genes","volume":"173","author":"Price","year":"1991","journal-title":"J Bacteriol"},{"issue":"5","key":"10.1016\/j.atc.2004.05.002_BIB44","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1128\/jb.173.5.1607-1616.1991","article-title":"Analysis of the V antigen lcrGVH-yopBD operon of Yersinia pseudotuberculosis: evidence for a regulatory role of LcrH and LcrV","volume":"173","author":"Bergman","year":"1991","journal-title":"J Bacteriol"},{"key":"10.1016\/j.atc.2004.05.002_BIB45","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/iai.51.2.445-454.1986","article-title":"Virulence genes regulated at the transcriptional level by Ca2+ in Yersinia pestis include structural genes for outer membrane proteins","volume":"51","author":"Straley","year":"1986","journal-title":"Infect Immun"},{"key":"10.1016\/j.atc.2004.05.002_BIB46","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1128\/jb.177.9.2530-2542.1995","article-title":"Differential effects of deletions in lcrV on secretion of V antigen, regulation of the low-Ca2+ response, and virulence of Yersinia pestis","volume":"177","author":"Skrzypek","year":"1995","journal-title":"J Bacteriol"},{"key":"10.1016\/j.atc.2004.05.002_BIB47","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1128\/JB.180.13.3410-3420.1998","article-title":"The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG","volume":"180","author":"Nilles","year":"1998","journal-title":"J Bacteriol"},{"key":"10.1016\/j.atc.2004.05.002_BIB48","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1046\/j.1365-2958.1999.01408.x","article-title":"The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation","volume":"32","author":"Pettersson","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.atc.2004.05.002_BIB49","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1046\/j.1365-2958.2001.02259.x","article-title":"LcrV is a channel size-determining component of the Yop effector translocon of Yersinia","volume":"39","author":"Holmstrom","year":"2001","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.atc.2004.05.002_BIB50","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1128\/iai.63.8.3021-3029.1995","article-title":"Suppresion of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization","volume":"63","author":"Nakajima","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.atc.2004.05.002_BIB51","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1084\/jem.20020908","article-title":"Yersinia V-antigen exploits Toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression","volume":"196","author":"Sing","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.atc.2004.05.002_BIB52","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.4049\/jimmunol.167.10.5880","article-title":"Therapeutic administration of anti-PcrV F(ab\u2032)2 in sepsis associated with Pseudomonas aeruginosa","volume":"167","author":"Shime","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.atc.2004.05.002_BIB53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1086\/341069","article-title":"Generation and characterization of a protective monoclonal antibody to Pseudomonas aeruginosa PcrV","volume":"186","author":"Frank","year":"2002","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.atc.2004.05.002_BIB54","first-page":"1","article-title":"Effects of monoclonal anti-PcrV antibody on Pseudomonas aeruginosa-induced acute lung injury in a rat model","volume":"1","author":"Faure","year":"2003","journal-title":"J Immune Based Ther Vaccines"},{"issue":"6","key":"10.1016\/j.atc.2004.05.002_BIB55","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.4049\/jimmunol.159.6.2858","article-title":"IL-10 improves lung injury and survival in Pseudomonas aeruginosa pneumonia","volume":"159","author":"Sawa","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.atc.2004.05.002_BIB56","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1128\/IAI.67.10.5395-5408.1999","article-title":"Virulence role of V antigen of Yersinia pestis at the bacterial cell surface","volume":"67","author":"Fields","year":"1999","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.atc.2004.05.002_BIB57","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1128\/JB.180.5.1207-1214.1998","article-title":"The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD","volume":"180","author":"Sarker","year":"1998","journal-title":"J Bacteriol"},{"issue":"5","key":"10.1016\/j.atc.2004.05.002_BIB58","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1046\/j.1365-2958.1998.00994.x","article-title":"Functional conservation of the effector protein translocators PopB\/YopB and PopD\/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosis","volume":"29","author":"Frithz-Lindsten","year":"1998","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.atc.2004.05.002_BIB59","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1128\/jb.179.4.1307-1316.1997","article-title":"Yersinia pestis LcrV forms a stable complex with LcrG and may have a secretion-related regulatory role in the low-Ca2+ response","volume":"179","author":"Nilles","year":"1997","journal-title":"J Bacteriol"},{"key":"10.1016\/j.atc.2004.05.002_BIB60","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2958.1999.01154.x","article-title":"Role of SycD. the chaperone of the Yersinia Yop translocators YopB and YopD","volume":"31","author":"Neyt","year":"1999","journal-title":"Mol Microbiol"},{"issue":"4","key":"10.1016\/j.atc.2004.05.002_BIB61","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1128\/IAI.71.4.2230-2233.2003","article-title":"Protein binding between PcrG-PcrV and PcrH-PopB\/PopD encoded by the pcrGVH-popBD operon of the Pseudomonas aeruginosa type III secretion system","volume":"71","author":"Allmond","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.atc.2004.05.002_BIB62","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1046\/j.1365-2958.2001.02368.x","article-title":"Pore-forming activity of type III system-secreted proteins leads to oncosis of Pseudomonas aeruginosa-infected macrophages","volume":"40","author":"Dacheux","year":"2001","journal-title":"Mol Microbiol"},{"issue":"6855","key":"10.1016\/j.atc.2004.05.002_BIB63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/35097083","article-title":"Genome sequence of Yersinia pestis, the causative agent of plague","volume":"413","author":"Parkhill","year":"2001","journal-title":"Nature"}],"container-title":["Anesthesiology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889853704000549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889853704000549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:02:59Z","timestamp":1760176979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889853704000549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0889853704000549"],"URL":"https:\/\/doi.org\/10.1016\/j.atc.2004.05.002","relation":{},"ISSN":["0889-8537"],"issn-type":[{"value":"0889-8537","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A therapeutic strategy against the shared virulence mechanism utilized by both Yersinia pestis and Pseudomonas aeruginosa","name":"articletitle","label":"Article Title"},{"value":"Anesthesiology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atc.2004.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}