{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:31:12Z","timestamp":1782887472831,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.atherosclerosis.2003.12.036","type":"journal-article","created":{"date-parts":[[2004,3,9]],"date-time":"2004-03-09T13:52:41Z","timestamp":1078840361000},"page":"43-48","source":"Crossref","is-referenced-by-count":27,"title":["Methionine synthase reductase MTRR 66A > G has no effect on total homocysteine, folate, and Vitamin B12 concentrations in renal transplant patients"],"prefix":"10.1016","volume":"174","author":[{"given":"Alexandra","family":"Feix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang C","family":"Winkelmayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Eberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gere","family":"Sunder-Plassmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"F\u00f6dinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000057459","article-title":"Molecular genetics of homocysteine metabolism","volume":"25","author":"F\u00f6dinger","year":"1999","journal-title":"Miner Electrolyte Metab"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB2","first-page":"20","article-title":"Molecular biology of 5,10-methylenetetrahydrofolate reductase","volume":"13","author":"F\u00f6dinger","year":"2000","journal-title":"J. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB3","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1073\/pnas.95.6.3059","article-title":"Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria","volume":"95","author":"Leclerc","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-1119(99)00431-X","article-title":"Molecular cloning, expression and physical mapping of the human methioine synthase reductase gene","volume":"240","author":"Leclerc","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB5","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1093\/hmg\/8.11.2009","article-title":"Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate\/cobalamin metabolism","volume":"8","author":"Wilson","year":"1999","journal-title":"Hum Mol. Genet"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/mgme.1999.2879","article-title":"A common variant in methionine synthase reductase combined with low cobalamin (Vitamin B12) increases risk for spina bifida","volume":"67","author":"Wilson","year":"1999","journal-title":"Mol. Genet Metab."},{"issue":"Suppl 84","key":"10.1016\/j.atherosclerosis.2003.12.036_BIB7","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.1046\/j.1523-1755.63.s84.52.x","article-title":"Genetic determinants of the homocysteine level","volume":"63","author":"Sunder-Plassmann","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB8","doi-asserted-by":"crossref","first-page":"13378","DOI":"10.1021\/bi020536s","article-title":"Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase","volume":"41","author":"Olteanu","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB9","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1681\/ASN.V11101918","article-title":"Effect of MTHFR 1298A > C and MTHFR 677C > T genotypes on total homocysteine, folate, and Vitamin B12 plasma concentrations in kidney graft recipients","volume":"11","author":"F\u00f6dinger","year":"2000","journal-title":"J. Am Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-4347(87)80438-3","article-title":"Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection","volume":"422","author":"Araki","year":"1987","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0021-9150(02)00204-6","article-title":"Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study","volume":"166","author":"Jacques","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase [letter]","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB13","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/301825","article-title":"A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?","volume":"62","author":"van der Put","year":"1998","journal-title":"Am J. Hum Genet"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/mgme.1998.2714","article-title":"A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity","volume":"64","author":"Weisberg","year":"1998","journal-title":"Mol. Genet Metab."},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB15","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1046\/j.1523-1755.2003.00025.x","article-title":"Effects of the glutamate carboxypeptidase II (GCP2 1561C > T) and reduced folate carrier (RFC1 80G > A) allelic variants on folate and total homocysteine levels in kidney transplant patients","volume":"63","author":"Winkelmayer","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB17","unstructured":"National Kidney Foundation (NKF) Kidney Disease Outcome Quality Initiative (K\/DOQI) Advisory Board. K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Kidney Disease Outcome Quality Initiative. Am J Kidney Dis 2002:39 (Suppl 2):S1\u2013246."},{"issue":"Suppl 1","key":"10.1016\/j.atherosclerosis.2003.12.036_BIB18","first-page":"36","article-title":"Identification of novel polymorphisms and analysis of haplotypes in the methionine synthase reductase gene [abstract]","volume":"26","author":"Zavadakova","year":"2003","journal-title":"J. Inherit Metab. Dis."},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB19","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1515\/CCLM.2001.115","article-title":"Genetic defects as important factors for moderate hyperhomocysteinemia","volume":"39","author":"Geisel","year":"2001","journal-title":"Clin. Chem. Lab Med."},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/204748730000700306","article-title":"A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease","volume":"7","author":"Brown","year":"2000","journal-title":"J. Cardiovasc. Risk"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/CVM-2-3-141","article-title":"Genetics University of Toronto Thrombophilia Study in Women (GUTTSI): genetic and other risk factors for venous thromboembolism in women","volume":"2","author":"Ray","year":"2001","journal-title":"Curr. Control Trials Cardiovasc. Med."},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB22","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1182\/blood.V101.7.2483","article-title":"Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults","volume":"101","author":"Kluijtmans","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0021-9150(00)00739-5","article-title":"The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations","volume":"157","author":"Gaughan","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2003.12.036_BIB24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0021-9150(02)00370-2","article-title":"Corrigendum to \u201cThe methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations\u201d [Atherosclerosis 157 (2001) 451\u2013456]","volume":"167","author":"Gaughan","year":"2002","journal-title":"Atherosclerosis"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915004000309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915004000309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T02:02:25Z","timestamp":1623722545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915004000309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0021915004000309"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2003.12.036","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}