{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:34:17Z","timestamp":1760204057394},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.atherosclerosis.2005.01.011","type":"journal-article","created":{"date-parts":[[2005,2,15]],"date-time":"2005-02-15T17:07:38Z","timestamp":1108487258000},"page":"69-73","source":"Crossref","is-referenced-by-count":24,"title":["Dysregulation of the endothelial nitric oxide synthase\u2013soluble guanylate cyclase pathway is normalized by insulin in the aorta of diabetic rat"],"prefix":"10.1016","volume":"181","author":[{"given":"Michela","family":"Zanetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Barazzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Stebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Roder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Biolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco E.","family":"Baralle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Cattin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Guarnieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/01.RES.0000082524.34487.31","article-title":"Regulation of nitric oxide-sensitive guanylyl cyclase","volume":"93","author":"Friebe","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/01.CIR.96.1.25","article-title":"High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells","volume":"96","author":"Cosentino","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib3","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0026-0495(99)90049-5","article-title":"A study on human umbilical cord endothelial cells: functional modifications by plasma from insulin-dependent diabetes mellitus patients","volume":"48","author":"Salvolini","year":"1999","journal-title":"Metabolism"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib4","first-page":"E11","article-title":"Effects of simulated hyperglycemia, insulin, and glucagons on endothelial nitric oxide synthase expression","volume":"279","author":"Ding","year":"2000","journal-title":"Am J Physiol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib5","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1172\/JCI11235","article-title":"Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site","volume":"108","author":"Du","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/0264-6021:3490353","article-title":"Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency","volume":"349","author":"Meininger","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3150281","article-title":"High glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or endothelial nitric oxide synthase","volume":"315","author":"Mancusi","year":"1996","journal-title":"Biochem J"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2005.01.011_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1113\/eph8802515","article-title":"Hyperglycemia inhibits thymidine incorporation and cell growth via protein kinase C, mitogen-activated protein kinases and nitric oxide in human umbilical vein endothelium","volume":"88","author":"Rojas","year":"2003","journal-title":"Exp Physiol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI118394","article-title":"Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus","volume":"97","author":"Ting","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib10","first-page":"684","article-title":"Plasma and vascular tissue arginine are decreased in diabetes: acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production","volume":"283","author":"Pieper","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib11","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/01.ATV.13.6.915","article-title":"Effect of elevated glucose on cyclic GMP and eicosanoids produced by porcine aortic endothelium","volume":"13","author":"Weisbrod","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1476-5381.1989.tb11993.x","article-title":"Impairment of endothelium-dependent relaxation and change of levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats","volume":"97","author":"Kamata","year":"1989","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib13","first-page":"13","article-title":"Decrease in endothelium-dependent relaxation and levels of cyclic nucleotides in aorta from rabbits with alloxan-induced diabetes","volume":"68","author":"Abiru","year":"1990","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/niox.2001.0363","article-title":"Dysfunction of soluble guanylyl cyclase in aorta and kidney of Goto-Kakizaki rats: influence of age and diabetic state","volume":"6","author":"Witte","year":"2002","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1464-410X.1994.tb16556.x","article-title":"Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: an in vitro study","author":"Miller","year":"1994","journal-title":"Br J Urol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib16","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/j.1476-5381.1996.tb15545.x","article-title":"Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta","volume":"118","author":"Papapetropoulos","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib17","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1097\/01.ASN.0000064947.14997.69","article-title":"Lead-induced downregulation of soluble guanylate cyclase in isolated rat aortic segments mediated by reactive oxygen species and cyclooxygenase-2","volume":"14","author":"Courtois","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib18","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1161\/01.CIR.0000051367.92927.07","article-title":"High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells","volume":"107","author":"Cosentino","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib19","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1161\/01.STR.0000099123.55171.3F","article-title":"Gene-targeted mice reveal a critical role for inducible nitric oxide synthase in vascular dysfunction during diabetes","volume":"34","author":"Gunnett","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0002-9149(01)02266-4","article-title":"Effect of insulin therapy on endothelium-dependent dilation in type 2 diabetes mellitus","volume":"89","author":"Gaenzer","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0024-3205(97)00292-0","article-title":"Divergent actions of chronic insulin treatment in vivo versus treatment ex vivo on diabetic-induced endothelial dysfunction","volume":"60","author":"Pieper","year":"1997","journal-title":"Life Sci"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1476-5381.1994.tb14020.x","article-title":"Prevention by insulin treatment of endothelial dysfunction but not enhanced noradrenaline-induced contractility in mesenteric resistance arteries from streptozotocin-induced diabetes mellitus in rats","volume":"111","author":"Taylor","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.ATV.0000113817.48983.c5","article-title":"3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes","volume":"24","author":"Vehkavaara","year":"2004","journal-title":"Arterioscl Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2005.01.011_bib24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/01.CIR.101.6.676","article-title":"Regulation of endothelial constitutive nitric oxide gene expression in endothelial cells and in vivo: a specific vascular action of insulin","volume":"101","author":"Kuboki","year":"2000","journal-title":"Circulation"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915005000596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915005000596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T17:57:56Z","timestamp":1548698276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915005000596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0021915005000596"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2005.01.011","relation":{},"ISSN":["0021-9150"],"issn-type":[{"type":"print","value":"0021-9150"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}