{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:15:01Z","timestamp":1777342501631,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.atherosclerosis.2005.01.038","type":"journal-article","created":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T12:45:35Z","timestamp":1109681135000},"page":"121-127","source":"Crossref","is-referenced-by-count":19,"title":["Correlation of plasma homocysteine level with arterial stiffness and pulse pressure in hemodialysis patients"],"prefix":"10.1016","volume":"182","author":[{"given":"Jer-Chia","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Tien","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Wen","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Jyh","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Yi","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jer-Ming","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Hsiung","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib1","first-page":"S16","article-title":"Epidemiology of cardiovascular disease in chronic renal disease","volume":"9","author":"Foley","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib2","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1161\/01.ATV.17.11.2554","article-title":"Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study","volume":"17","author":"Bostom","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1046\/j.1523-1755.2002.00144.x","article-title":"Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients","volume":"61","author":"Mallamaci","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib4","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1046\/j.1523-1755.2003.00932.x","article-title":"Aortic pulse wave velocity index and mortality in end-stage renal disease","volume":"63","author":"Blacher","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib5","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0895-7061(02)02966-7","article-title":"Prognostic application of arterial stiffness: task forces","volume":"15","author":"London","year":"2002","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib6","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0895-7061(02)03029-7","article-title":"Influence of age, risk factors, and cardiovascular and renal disease on arterial stiffness: clinical applications","volume":"15","author":"Benetos","year":"2002","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.atherosclerosis.2003.08.003","article-title":"Arterial stiffness is rapidly induced by raising the plasma homocysteine concentration with methionine","volume":"171","author":"Nestel","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005344-200101000-00001","article-title":"Acute methionine loading does not alter arterial stiffness in humans","volume":"37","author":"Wilkinson","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib9","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.HYP.34.4.837","article-title":"Plasma homocysteine, aortic stiffness, and renal function in hypertensive patients","volume":"34","author":"Bortolotto","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/01.ATV.18.4.535","article-title":"Influence of biochemical alterations on arterial stiffness in patients with end-stage renal disease","volume":"18","author":"Blacher","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib11","first-page":"33","article-title":"Carotid artery stiffness in patients with end-stage renal disease: no effect of long-term homocysteine-lowering therapy","volume":"53","author":"van Guldener","year":"2000","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1046\/j.1523-1755.2002.00173.x","article-title":"Pulse pressure and risk of total mortality and cardiovascular events in patients on chronic hemodialysis","volume":"61","author":"Tozawa","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib13","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1001\/jama.287.12.1548","article-title":"Association between pulse pressure and mortality in patients undergoing maintenance hemodialysis","volume":"287","author":"Klassen","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib14","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0735-1097(01)01108-1","article-title":"Pulse pressure\u2014a review of mechanisms and clinical relevance","volume":"37","author":"Dart","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib15","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1161\/01.CIR.96.6.1745","article-title":"High homocysteine levels are independently related to isolated systolic hypertension in older adults","volume":"96","author":"Sutton-Tyrrell","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib16","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/aje\/kwf157","article-title":"Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survey","volume":"156","author":"Lim","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib17","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.HYP.0000101690.58391.13","article-title":"Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study","volume":"42","author":"Sundstrom","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11906-003-0007-z","article-title":"Homocysteine and blood pressure","volume":"5","author":"van Guldener","year":"2003","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib19","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/01.ATV.0000060460.52916.D6","article-title":"Noninvasive assessment of arterial stiffness and risk of atherosclerotic events","volume":"23","author":"Oliver","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib20","first-page":"34","article-title":"Noninvasive assessment of cardiovascular risk: from Framingham to the future","volume":"1","author":"Vogel","year":"2000","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1444-1586.2002.00045.x","article-title":"Arterial stiffness index: a new evaluation for arterial stiffness in elderly patients with essential hypertension","volume":"2002","author":"Kaibe","year":"2002","journal-title":"Geriatric Geront Int"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib22","doi-asserted-by":"crossref","first-page":"131A","DOI":"10.1016\/j.amjhyper.2004.03.347","article-title":"A novel arterial stiffness index (ASI) as a marker of arteriosclerosis","volume":"17","author":"Hiramatsu","year":"2004","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib23","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/ki.1985.160","article-title":"A mechanistic analysis of the National Cooperative Dialysis Study (NCDS)","volume":"28","author":"Gotch","year":"1985","journal-title":"Kidney Int"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib25","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.CIR.103.7.987","article-title":"Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure","volume":"103","author":"Guerin","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib26","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1097\/01.ASN.0000019641.41496.1E","article-title":"Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE study","volume":"13","author":"Longenecker","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib27","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1161\/01.CIR.0000035250.66458.67","article-title":"Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease","volume":"106","author":"Drueke","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib28","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1523-1755.2004.00813.x","article-title":"Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients","volume":"66","author":"Anraku","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib29","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1073\/pnas.91.14.6369","article-title":"Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis","volume":"91","author":"Tsai","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib30","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1172\/JCI8342","article-title":"Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia","volume":"106","author":"Eberhardt","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0021-9150(96)06016-9","article-title":"Lipid peroxidation induced in vivo by hyperhomocysteinaemia in pigs","volume":"129","author":"Young","year":"1997","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib32","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1042\/CS19980064","article-title":"Augmented effects of methionine and cholesterol in decreasing the elastic lamina while thickening the aortic wall in the rat aorta","volume":"95","author":"Zulli","year":"1998","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.0306-5251.2001.01447.x","article-title":"Acute hyperhomocysteinaemia affects pulse pressure but not microvascular vasodilator function","volume":"52","author":"Davis","year":"2001","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib34","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1046\/j.1523-1755.2002.00665.x","article-title":"Evidence for elevated pulse pressure in patients on chronic hemodialysis: a case-control study","volume":"62","author":"Tozawa","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib35","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1161\/hc4601.098514","article-title":"Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine","volume":"104","author":"Stuhlinger","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib36","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.100.11.1161","article-title":"Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans","volume":"100","author":"Kanani","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib37","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/01.CIR.0000050628.11305.30","article-title":"The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: a randomized, controlled trial","volume":"107","author":"Tepel","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib38","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.CIR.0000109492.65802.AD","article-title":"Acetylcysteine reduces plasma homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure","volume":"109","author":"Scholze","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib39","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1161\/01.HYP.0000128420.01881.aa","article-title":"Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study","volume":"43","author":"Mitchell","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2005.01.038_bib40","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/ndt\/gfg414","article-title":"Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality","volume":"18","author":"London","year":"2003","journal-title":"Nephrol Dial Transplant"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915005001103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915005001103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T11:50:37Z","timestamp":1548676237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915005001103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0021915005001103"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2005.01.038","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}