{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:36:16Z","timestamp":1781825776280,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.atherosclerosis.2005.02.002","type":"journal-article","created":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T12:45:35Z","timestamp":1109681135000},"page":"135-143","source":"Crossref","is-referenced-by-count":43,"title":["Interleukin-18: Interleukin-10 ratio and in-hospital adverse events in patients with acute coronary syndrome"],"prefix":"10.1016","volume":"182","author":[{"given":"Georgios K.","family":"Chalikias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios N.","family":"Tziakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Kaski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni I.","family":"Hatzinikolaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios A.","family":"Stakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis K.","family":"Tentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Kortsaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios I.","family":"Hatseras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib1","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1161\/01.CIR.91.11.2844","article-title":"Molecular bases of acute coronary syndromes","volume":"91","author":"Libby","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis: an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib3","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/01.CIR.94.5.874","article-title":"Elevated levels of interleukin-6 in unstable angina","volume":"94","author":"Biasucci","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/heart.88.5.467","article-title":"Increased plasma concentrations of interleukin-18 in acute coronary syndromes","volume":"88","author":"Mallat","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib5","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/hc3201.094973","article-title":"Serum levels of the anti inflammatory cytokine interleukin-10 are decreased in patients with unstable angina","volume":"104","author":"Smith","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib6","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1161\/01.RES.85.8.e17","article-title":"Protective role of interleukin-10 in atherosclerosis","volume":"85","author":"Mallat","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib7","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1161\/01.ATV.19.12.2847","article-title":"Interleukin-10 blocks atherosclerotic events in vitro and in vivo","volume":"19","author":"Pinderski Oslund","year":"1999","journal-title":"Atheroscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib8","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1161\/hq1201.100220","article-title":"Immune mechanisms in atherosclerosis","volume":"21","author":"Hansson","year":"2001","journal-title":"Atheroscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.immunol.19.1.423","article-title":"Interleukin-18 regulates both Th1 and Th2 responses","volume":"19","author":"Nakanishi","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3109\/07853899509002465","article-title":"Immunosuppressive and anti-inflammatory properties of interleukin-10","volume":"27","author":"de Vries","year":"1995","journal-title":"Ann Med"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/01.CIR.0000020546.30940.92","article-title":"Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina","volume":"106","author":"Blankenberg","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib12","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1161\/01.CIR.0000065232.57371.25","article-title":"Serum level of the anti inflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes","volume":"107","author":"Heeschen","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib13","doi-asserted-by":"crossref","unstructured":"Myocardial infarction redefined\u2014a consensus document of the Joint European Society of Cardiology\/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. Eur Heart J 2000;21:1502\u201313.","DOI":"10.1053\/euhj.2000.2305"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib14","unstructured":"ACC clinical data standards. American College of Cardiology Key Data Elements and Definition for Measuring the Clinical Management and Outcomes of Patients with Acute Coronary Syndromes. JACC 2001;38:2114\u201330."},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib15","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/01.CIR.80.2.410","article-title":"Unstable angina: a classification","volume":"80","author":"Braunwald","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib16","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1161\/01.CIR.102.17.2031","article-title":"TIMI risk score for ST-elevation myocardial infarction: a convenient, bedside, clinical score for risk assessment at presentation an intravenous nPA for treatment of infarcting myocardium early II trial substudy","volume":"102","author":"Morrow","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib17","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1001\/jama.284.7.835","article-title":"The TIMI risk score for unstable angina\/non ST elevation MI. A method for prognostication and therapeutic decision making","volume":"284","author":"Antman","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0002-9149(67)90023-9","article-title":"Treatment of myocardial infarction in a coronary care unit. A two year experience with 250 patients","volume":"20","author":"Killip","year":"1967","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib19","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1177\/000456329803500607","article-title":"Analytical evaluation of particle enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum","volume":"35","author":"Ledue","year":"1998","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib20","doi-asserted-by":"crossref","first-page":"9558","DOI":"10.1074\/jbc.270.16.9558","article-title":"Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms","volume":"270","author":"Wang","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib21","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1172\/JCI118286","article-title":"IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes","volume":"96","author":"Lacraz","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1046\/j.1365-2141.1998.00808.x","article-title":"IL-10 inhibits LPS-induced human monocyte tissue factor expression in whole blood","volume":"102","author":"Lindmark","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib23","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1161\/01.RES.0000018941.10726.FA","article-title":"Overexpresion of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient mice by altering lymphocyte and macrophages phenotypes","volume":"90","author":"Pinderski","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/01.ATV.19.3.611","article-title":"Tedgui A Expression of interleukin-10 in advanced human atherosclerotic plaques","volume":"19","author":"Mallat","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/378088a0","article-title":"Cloning of a new cytokine that induces IFN-gamma production by T cells","volume":"378","author":"Okamura","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib26","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1073\/pnas.97.2.734","article-title":"IL-18 regulates IL-1beta\u2014dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1","volume":"97","author":"Vidal-Vanaclocha","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib27","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1172\/JCI1379","article-title":"Interelukin-18 (IFN gamma-inducing factor) induces IL-8 and IL-1 beta via TNF-alpha production from non-CD14+ human blood mononuclear cells","volume":"101","author":"Puren","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib28","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/jlb.63.6.658","article-title":"Overview of interleukin-18: more than an interferon gamma inducing factor","volume":"63","author":"Dinarello","year":"1998","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib29","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/hc3901.096721","article-title":"Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability","volume":"104","author":"Mallat","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib30","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1046\/j.1365-2362.2002.01069.x","article-title":"Inflammatory imbalance between IL-10 and TNF-\u03b1 in unstable angina potential plaque stabilizing effects of IL-10","volume":"32","author":"Waehre","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2005.02.002_bib31","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1172\/JCI118650","article-title":"Cross regulatory roles of intelreukin-12 and interleukin-10 in atherosclerosis","volume":"97","author":"Uyemura","year":"1996","journal-title":"J Clin Invest"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915005001140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915005001140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T09:20:40Z","timestamp":1548926440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915005001140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0021915005001140"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2005.02.002","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}