{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:21:21Z","timestamp":1783455681710,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.atherosclerosis.2007.06.006","type":"journal-article","created":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T10:29:56Z","timestamp":1185532196000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Are statins effective for simultaneously treating dyslipidemias and hypertension?"],"prefix":"10.1016","volume":"196","author":[{"given":"Kwang Kon","family":"Koh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Quon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron A.","family":"Waclawiw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0008-6363(00)00146-2","article-title":"Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability","volume":"47","author":"Koh","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib2","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1161\/01.CIR.100.21.2131","article-title":"Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men","volume":"100","author":"Nickenig","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib3","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1161\/01.HYP.37.6.1450","article-title":"HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species","volume":"37","author":"Wassmann","year":"2001","journal-title":"Hypertension"},{"issue":"Pt 1","key":"10.1016\/j.atherosclerosis.2007.06.006_bib4","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0895-7061(01)02210-5","article-title":"Treatment with atorvastatin improves small artery compliance in patients with severe hypercholesterolemia","volume":"14","author":"Leibovitz","year":"2001","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib5","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/S0735-1097(02)01717-5","article-title":"Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension","volume":"39","author":"Ferrier","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib6","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0140-6736(95)90345-3","article-title":"Hyperlipidaemia, hypertension, and coronary heart disease","volume":"354","author":"Goode","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib7","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.HYP.36.3.e1","article-title":"Pravastatin, blood pressure, and stroke","volume":"36","author":"Wilkinson","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0021-9150(96)05834-0","article-title":"Impaired radial artery compliance in normotensive subjects with familial hypercholesterolemia","volume":"124","author":"Giannattasio","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00198301","article-title":"Does lowering of cholesterol levels influence functional properties of large arteries?","volume":"48","author":"Kool","year":"1995","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib10","first-page":"108","article-title":"Effect of plasma cholesterol reduction by pravastatin on the functional properties of forearm arteries in hypercholesterolemic patients","volume":"9","author":"Baldassarre","year":"1999","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3109\/08037059409102294","article-title":"Short term effects of pravastatin on blood pressure in hypercholesterolaemic hypertensive patients","volume":"3","author":"O\u2019Callaghan","year":"1994","journal-title":"Blood Press"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/028134399750002764","article-title":"Treatment of hypertensive and hypercholesterolaemic patients in general practice. The effect of captopril, atenolol and pravastatin combined with life style intervention","volume":"17","author":"Foss","year":"1999","journal-title":"Scand J Prim Health Care"},{"issue":"Suppl. III","key":"10.1016\/j.atherosclerosis.2007.06.006_bib13","first-page":"III-402","article-title":"A multicenter double-blind randomized controlled trial of a statin+angiotensin receptor blockade combination in patients with hypertension and concomitant hyperlipidemia","volume":"110","author":"Rajagopalan","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib14","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.amjhyper.2004.02.002","article-title":"Pravastatin has an additional depressor effect in patients undergoing long-term treatment with antihypertensive drugs","volume":"17","author":"Ikeda","year":"2004","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/00005344-200004000-00006","article-title":"Use of statins and blood pressure control in treated hypertensive patients with hypercholesterolemia","volume":"35","author":"Borghi","year":"2000","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1497\u20139","key":"10.1016\/j.atherosclerosis.2007.06.006_bib16","first-page":"A8","article-title":"Additional reduction in blood pressure after cholesterol-lowering treatment by statins (lovastatin or pravastatin) in hypercholesterolemic patients using angiotensin-converting enzyme inhibitors (enalapril or lisinopril)","volume":"83","author":"Sposito","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib17","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1161\/01.HYP.34.6.1281","article-title":"Effect of the HMG-CoA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia","volume":"34","author":"Glorioso","year":"1999","journal-title":"Hypertension"},{"issue":"Pt. 2","key":"10.1016\/j.atherosclerosis.2007.06.006_bib18","first-page":"H2701","article-title":"Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression","volume":"272","author":"Nickenig","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib19","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1161\/01.CIR.0000143085.86697.13","article-title":"Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients","volume":"110","author":"Koh","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib20","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1161\/01.HYP.0000166722.91714.ba","article-title":"Vascular and metabolic effects of combined therapy with ramipril and simvastatin in patients with type 2 diabetes","volume":"45","author":"Koh","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib21","first-page":"742","article-title":"Resistant arterial hypertension and hyperlipidemia: atorvastatin, not vitamin C, for blood pressure control","volume":"6","author":"Magen","year":"2004","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1081\/JDI-56610","article-title":"Statin therapy helps to control blood pressure levels in hypertensive dyslipidemic patients","volume":"27","author":"Kanbay","year":"2005","journal-title":"Ren Fail"},{"issue":"Suppl. 1","key":"10.1016\/j.atherosclerosis.2007.06.006_bib23","doi-asserted-by":"crossref","first-page":"A2","DOI":"10.1016\/j.amjhyper.2005.03.005","article-title":"Atorvastatin reduces ambulatory blood pressure in hyperlipidemic patients with untreated grade 1 essential hypertension","volume":"18","author":"Calvo","year":"2005","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib24","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.amjhyper.2004.06.005","article-title":"Effect of amlodipine-atorvastatin combination on fibrinolysis in hypertensive hypercholesterolemic patients with insulin resistance","volume":"17","author":"Fogari","year":"2004","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib25","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0002-9149(99)80621-3","article-title":"Effects of pravastatin on cardiovascular reactivity to norepinephrine and angiotensin II in patients with hypercholesterolemia and systemic hypertension","volume":"75","author":"Straznicky","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1046\/j.1365-2796.1998.00350.x","article-title":"Diet and pravastatin in moderate hypercholesterolaemia: a randomized trial in 215 middle-aged men free from cardiovascular disease","volume":"244","author":"Bak","year":"1998","journal-title":"J Intern Med"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib27","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1001\/jama.290.4.502","article-title":"Effects of a dietary portfolio of cholesterol-lowering foods vs. lovastatin on serum lipids and C-reactive protein","volume":"290","author":"Jenkins","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib28","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0149-2918(03)80070-X","article-title":"Randomized, double-blind, placebo-controlled comparison of the action of orlistat, fluvastatin, or both an anthropometric measurements, blood pressure, and lipid profile in obese patients with hypercholesterolemia prescribed a standardized diet","volume":"25","author":"Derosa","year":"2003","journal-title":"Clin Ther"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0021-9150(00)00558-X","article-title":"Simvastatin improves arterial compliance in the lower limb but not in the aorta","volume":"155","author":"Shige","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib30","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/00005344-200212000-00007","article-title":"Association of pravastatin and left ventricular mass in hypercholesterolemic patients: role of 8-iso-prostaglandin f2alpha formation","volume":"40","author":"Lee","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib31","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.2337\/diacare.20.12.1891","article-title":"Reduction of albumin excretion rate in normotensive microalbuminuric type 2 diabetic patients during long-term simvastatin treatment","volume":"20","author":"Tonolo","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib32","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/01.fjc.0000175432.56789.e6","article-title":"Lowering of elevated ambulatory blood pressure by HMG-CoA reductase inhibitors","volume":"46","author":"Terzoli","year":"2005","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ahj.2004.02.003","article-title":"Brisighella Heart Study Working Party Association between different lipid-lowering treatment strategies and blood pressure control in the Brisighella Heart Study","volume":"148","author":"Borghi","year":"2004","journal-title":"Am Heart J"},{"issue":"Suppl. III","key":"10.1016\/j.atherosclerosis.2007.06.006_bib34","first-page":"III-402","article-title":"Statins lower blood pressure: results from the UCSD statin study","volume":"110","author":"Golomb","year":"2004","journal-title":"Circulation"},{"issue":"Suppl. III","key":"10.1016\/j.atherosclerosis.2007.06.006_bib35","first-page":"III-402","article-title":"Do statins lower blood pressure? Evidence from the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA)","volume":"110","author":"Poulter","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib36","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/01.HYP.0000259737.43916.42","article-title":"Do statins reduce blood pressure? A meta-analysis of randomized controlled trials","volume":"49","author":"Strazzullo","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib37","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/01.ATV.0000069209.26507.BF","article-title":"Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function","volume":"23","author":"Rodriguez-Porcel","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.CIR.95.2.473","article-title":"Upregulation of vascular angiotensin II receptor gene expression by low-density lipoprotein in vascular smooth muscle cells","volume":"95","author":"Nickenig","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib39","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0735-1097(03)00846-5","article-title":"Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients","volume":"42","author":"Koh","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/01.RES.85.1.23","article-title":"Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension","volume":"85","author":"Fukai","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib41","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/01.CIR.0000061916.95736.E5","article-title":"C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle","volume":"107","author":"Wang","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/01.HYP.0000024348.87637.6F","article-title":"Simvastatin prevents angiotensin II-induced cardiac alteration and oxidative stress","volume":"40","author":"Delbosc","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib43","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/01.CIR.103.3.448","article-title":"Angiotensin II-induced hypertension accelerates the development of atherosclerosis in apoE-deficient mice","volume":"103","author":"Weiss","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib44","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1161\/01.HYP.0000145179.44166.0f","article-title":"Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis","volume":"44","author":"Li","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib45","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(05)67185-1","volume":"366","author":"Dahlof","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib46","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.104.528166","article-title":"Candesartan in heart failure assessment of reduction in mortality and morbidity program investigators. Effects of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure","volume":"112","author":"Yusuf","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib47","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.jacc.2005.06.082","article-title":"Inflammatory markers and the metabolic syndrome: insights from therapeutic interventions","volume":"46","author":"Koh","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib48","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1161\/01.HYP.0000187900.36455.4c","article-title":"Beneficial vascular and metabolic effects of peroxisome proliferator-activated receptor-alpha activators","volume":"46","author":"Han","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib49","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1161\/CIRCULATIONAHA.105.563213","article-title":"Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms","volume":"113","author":"Kim","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.06.006_bib50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jacc.2006.08.061","article-title":"Adiponectin and cardiovascular disease: response to therapeutic interventions","volume":"49","author":"Han","year":"2007","journal-title":"J Am Coll Cardiol"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915007003917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915007003917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:19:19Z","timestamp":1762186759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915007003917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0021915007003917"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2007.06.006","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are statins effective for simultaneously treating dyslipidemias and hypertension?","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2007.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}