{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:34:24Z","timestamp":1791941664489,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.atherosclerosis.2007.07.038","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T10:54:27Z","timestamp":1191322467000},"page":"868-876","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: The GEMS Study"],"prefix":"10.1016","volume":"197","author":[{"given":"Heide","family":"Stirnadel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kijoung","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Barter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Antero","family":"Kes\u00e4niemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Mahley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Waeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bersot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Grundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braxton","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Mooser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Waterworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib1","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","article-title":"Banting lecture: role of insulin resistance in human disease","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/jama.287.3.356","article-title":"Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey","volume":"287","author":"Ford","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib3","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1001\/jama.288.21.2709","article-title":"The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men","volume":"288","author":"Lakka","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2337\/diacare.28.2.385","article-title":"The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities study","volume":"28","author":"McNeill","year":"2005","journal-title":"Diab Care"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib5","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/aje\/kwf145","article-title":"Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study","volume":"156","author":"Laaksonen","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib6","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.2337\/diabetes.53.4.1166","article-title":"Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese-Americans","volume":"53","author":"Austin","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib7","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.2337\/diabetes.51.8.2642","article-title":"Factor analysis of metabolic syndrome using directly measured insulin sensitivity: The Insulin Resistance Atherosclerosis Study","volume":"51","author":"Hanley","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-7075-2-2","article-title":"An evaluation of the metabolic syndrome in the HyperGEN Study","volume":"2","author":"Kraja","year":"2005","journal-title":"Nutr Metab (Lond)"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib9","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.2337\/diacare.24.10.1758","article-title":"Do different dimensions of the metabolic syndrome change together over time? Evidence supporting obesity as the central feature","volume":"24","author":"Maison","year":"2001","journal-title":"Diab Care"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib10","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.2337\/diacare.46.10.1594","article-title":"Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study","volume":"46","author":"Meigs","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib11","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/aje\/152.10.897","article-title":"Clustering of procoagulation, inflammation, and fibrinolysis variables with metabolic factors in insulin resistance syndrome","volume":"152","author":"Sakkinen","year":"2000","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/aje\/kwg045","article-title":"Are metabolic risk factors one unified syndrome? Modeling the structure of the metabolic syndrome X","volume":"157","author":"Shen","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib13","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.2337\/diabetes.52.11.2840","article-title":"Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study","volume":"52","author":"Tang","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib14","doi-asserted-by":"crossref","first-page":"841","DOI":"10.2337\/diabetes.51.3.841","article-title":"Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans","volume":"51","author":"Arya","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib15","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1210\/jc.2003-030553","article-title":"Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study","volume":"88","author":"Loos","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib16","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.amjcard.2004.08.091","article-title":"Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project)","volume":"95","author":"Wyszynski","year":"2005","journal-title":"Am J Cardiol"},{"issue":"4","key":"10.1016\/j.atherosclerosis.2007.07.038_bib17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1469-1809.1982.tb01588.x","article-title":"Extensions to multivariate normal models for pedigree analysis","volume":"46","author":"Hopper","year":"1982","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1469-1809.1976.tb00156.x","article-title":"Extensions to pedigree analysis. III. Variance components by the scoring method","volume":"39","author":"Lange","year":"1976","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib19","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"Almasy","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ajmg.1320140315","article-title":"Extensions to pedigree analysis. IV. Covariance components models for multivariate traits","volume":"14","author":"Lange","year":"1983","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/01.ATV.16.2.281","article-title":"Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures","volume":"16","author":"Mitchell","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib22","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1210\/jc.2006-2219","article-title":"Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia","volume":"92","author":"Barter","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib23","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00125-003-1074-z","article-title":"Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex","volume":"46","author":"Cnop","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib24","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1210\/jc.2004-1711","article-title":"Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men","volume":"90","author":"Cote","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11883-005-0076-3","article-title":"Adipocytokines: emerging therapeutic targets","volume":"7","author":"Matsuzawa","year":"2005","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib26","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.2337\/diabetes.53.7.1773","article-title":"Metabolic and inflammation variable clusters and prediction of type 2 diabetes: factor analysis using directly measured insulin sensitivity","volume":"53","author":"Hanley","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib27","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.metabol.2004.10.016","article-title":"Association of low adiponectin levels with the metabolic syndrome\u2013the Chennai Urban Rural Epidemiology Study (CURES-4)","volume":"54","author":"Mohan","year":"2005","journal-title":"Metabolism"},{"issue":"11","key":"10.1016\/j.atherosclerosis.2007.07.038_bib28","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1161\/01.ATV.17.11.3263","article-title":"Familial resemblance of plasma lipids, lipoproteins and post-heparin lipoprotein and hepatic lipases in the HERITAGE Family Study","volume":"17","author":"Perusse","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib29","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1210\/jcem.86.9.7878","article-title":"The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome","volume":"86","author":"Comuzzie","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.atherosclerosis.2007.07.038_bib30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2337\/diabetes.54.1.268","article-title":"Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene","volume":"54","author":"Pollin","year":"2005","journal-title":"Diabetes"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915007004868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915007004868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:33:24Z","timestamp":1758155604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915007004868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0021915007004868"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2007.07.038","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: The GEMS Study","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2007.07.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}