{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:50:45Z","timestamp":1758199845313,"version":"3.44.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.atherosclerosis.2007.08.021","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T13:16:46Z","timestamp":1190985406000},"page":"588-595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Simvastatin reduces platelet\u2013endocardium adhesion in atrial fibrillation"],"prefix":"10.1016","volume":"197","author":[{"given":"Massimo","family":"Chello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Spadaccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Patti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Lusini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Barbato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costanza","family":"Goffredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germano","family":"Di Sciascio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvio","family":"Covino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: the Framingham study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/01.STR.32.3.803","article-title":"Atrial fibrillation and stroke concepts and controversies","volume":"32","author":"Hart","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/01.CIR.94.3.425","article-title":"Fibrin d-dimer and \u03b2-thromboglobulin as markers of thrombogenesis and platelet activation in atrial fibrillation","volume":"94","author":"Lip","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib4","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1161\/01.CIR.0000102969.09658.F2","article-title":"Thrombomodulin and tissue factor pathway inhibitor in endocardium of rapidly paced rat atria","volume":"108","author":"Yamashita","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib5","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1053\/euhj.2002.3259","article-title":"A study of platelet activation in atrial fibrillation and the effects of antithrombotic therapy","volume":"23","author":"Kamath","year":"2002","journal-title":"Eur Heart J"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib6","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1161\/01.CIR.91.5.1588","article-title":"Chronic rapid atrial pacing. Structural, functional, and electrophysiological Simon P characteristics of a new model of sustained atrial fibrillation","volume":"91","author":"Morillo","year":"1995","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2007.08.021_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000089355","article-title":"Platelets, inflammation, and atherothrombotic neurovascular disease: the role of endothelial dysfunction","volume":"20","author":"Blanco","year":"2005","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib8","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/01.RES.0000074030.98009.FF","article-title":"CD40\u2013CD40L and platelet function: beyond hemostasis","volume":"92","author":"Freedman","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib9","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/01.RES.0000070111.98158.6C","article-title":"CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation","volume":"92","author":"Inwald","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib10","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1073\/pnas.97.13.6930","article-title":"Atherosclerosis: the emerging role of inflammation and the CD40\u2013CD40 ligand system","volume":"97","author":"Phipps","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib12","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.jacc.2004.03.023","article-title":"Soluble CD40 ligand and platelets: self-perpetuating pathogenic loop in thrombosis and inflammation?","volume":"16","author":"Aukrust","year":"2004","journal-title":"JACC"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.CIR.0000025419.95769.F0","article-title":"Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy","volume":"106","author":"Cipollone","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0008-6363(03)00515-7","article-title":"Statin (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells","volume":"59","author":"Mulhaupt","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib15","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1161\/01.ATV.0000037098.20829.31","article-title":"3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells","volume":"22","author":"Wagner","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0049-3848(96)00188-0","article-title":"Does warfarin enhance platelet activity?","volume":"84","author":"Mieszczak","year":"1996","journal-title":"Thromb Res"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.CIR.0000153810.81187.7D","article-title":"Short-term treatment with atorvastatin reduces platelet CD40 ligand and thrombin generation in hypercholesterolemic patients","volume":"111","author":"Sanguigni","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nm0302-247","article-title":"CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism","volume":"8","author":"Andre","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib19","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1161\/hc4501.099312","article-title":"Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia","volume":"104","author":"Garlichs","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0008-6363(00)00247-9","article-title":"Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concept for cardiovascular disease","volume":"49","author":"Lefer","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0008-6363(01)00418-7","article-title":"Emerging mechanisms for secondary cardioprotective effects of statins","volume":"52","author":"Miller","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib22","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/01.CCM.0000201407.89977.EA","article-title":"Effects of atorvastatin on systemic inflammatory response after coronary bypass surgery","volume":"34","author":"Chello","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.atherosclerosis.2007.08.021_bib23","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.STR.0000260090.90508.3e","article-title":"High-sensitivity C-reactive protein and soluble CD40 ligand as indices of inflammation and platelet activation in 880 patients with nonvalvular atrial fibrillation: relationship to stroke risk factors, stroke risk stratification schema, and prognosis","volume":"38","author":"Lip","year":"2007","journal-title":"Stroke"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915007005345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915007005345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:28:48Z","timestamp":1758155328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915007005345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0021915007005345"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2007.08.021","relation":{},"ISSN":["0021-9150"],"issn-type":[{"type":"print","value":"0021-9150"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simvastatin reduces platelet\u2013endocardium adhesion in atrial fibrillation","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2007.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}