{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:13:44Z","timestamp":1791112424221,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.atherosclerosis.2007.09.023","type":"journal-article","created":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T17:15:53Z","timestamp":1196788553000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Enhanced removal of cholesterol from macrophage foam cells to serum from type IV hypertriglyceridemic subjects"],"prefix":"10.1016","volume":"198","author":[{"given":"Nesrine","family":"Attia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Ramaharo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Cambillau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Beaune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Grynberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9150(95)05675-0","article-title":"High density lipoproteins and coronary heart disease","volume":"121","author":"Barter","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1161\/01.ATV.21.1.13","article-title":"High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport","volume":"21","author":"von Eckardstein","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib3","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0022-2275(20)32113-1","article-title":"Cell cholesterol efflux: integration of old and new observations provides new insights","volume":"40","author":"Rothblat","year":"1999","journal-title":"J Lipid Res"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib4","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/01.ATV.0000057572.97137.DD","article-title":"Importance of different pathways of cellular cholesterol efflux","volume":"23","author":"Yancey","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0140-6736(02)07277-X","article-title":"Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study","volume":"359","author":"van Dam","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib6","doi-asserted-by":"crossref","first-page":"9930","DOI":"10.1074\/jbc.M312476200","article-title":"Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1- but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein","volume":"279","author":"Favari","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib7","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1161\/01.ATV.17.11.2685","article-title":"HDL phospholipid content and composition as a major factor determining cholesterol efflux capacity from Fu5AH cells to human serum","volume":"17","author":"Fournier","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib8","doi-asserted-by":"crossref","first-page":"9774","DOI":"10.1073\/pnas.0403506101","article-title":"ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins","volume":"101","author":"Wang","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib9","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/01.ATV.0000200082.58536.e1","article-title":"ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I","volume":"26","author":"Gelissen","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib10","doi-asserted-by":"crossref","first-page":"13F","DOI":"10.1016\/S0002-9149(99)00209-X","article-title":"Epidemiology of hypertriglyceridemia and cardiovascular disease","volume":"83","author":"Austin","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib11","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1161\/01.ATV.15.12.2130","article-title":"Abnormal reverse cholesterol transport in controlled type II diabetic patients. Studies on fasting and postprandial LpA-I particles","volume":"15","author":"Cavallero","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0021-9150(99)00452-9","article-title":"Alterations in the main steps of reverse cholesterol transport in male patients with primary hypertriglyceridemia and low HDL-cholesterol levels","volume":"152","author":"Brites","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0021-9150(00)00691-2","article-title":"Twenty four hour insulin infusion impairs the ability of plasma from healthy subjects and type 2 diabetic patients to promote cellular cholesterol efflux","volume":"157","author":"Dullaart","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0021-9150(00)00730-9","article-title":"Analysis of the relationship between triglyceridemia and HDL-phospholipid concentrations: consequences on the efflux capacity of serum in the Fu5AH system","volume":"157","author":"Fournier","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.atherosclerosis.2003.08.011","article-title":"Enhanced efflux of cholesterol from ABCA1-expressing macrophages to serum from type IV hypertriglyceridemic subjects","volume":"171","author":"Fournier","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib16","article-title":"Increased cholesterol efflux from cultured fibroblasts to plasma from hypertriglyceridemic type 2 diabetic patients: roles of pre beta-HDL, phospholipid transfer protein and cholesterol esterification","author":"de Vries","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib17","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2362.2006.01673.x","article-title":"Comparison of different cellular models measuring in vitro the whole human serum cholesterol efflux capacity","volume":"36","author":"Mweva","year":"2006","journal-title":"Eur J Clin Invest"},{"issue":"Suppl.","key":"10.1016\/j.atherosclerosis.2007.09.023_bib18","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/0021-9150(96)05851-0","article-title":"Lipids, risk factors and ischaemic heart disease","volume":"124","author":"Castelli","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib19","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1016\/0002-9343(91)90054-2","article-title":"Rationale for treatment","volume":"91","author":"Gotto","year":"1991","journal-title":"Am J Med"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib20","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/clinchem\/37.7.1149","article-title":"Cholesterol distribution between high-density-lipoprotein subfractions HDL2 and HDL3 determined in serum by discontinuous gradient gel electrophoresis","volume":"37","author":"Atger","year":"1991","journal-title":"Clin Chem"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib21","doi-asserted-by":"crossref","first-page":"28634","DOI":"10.1074\/jbc.M003407200","article-title":"The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines","volume":"275","author":"Bortnick","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib22","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.ATV.15.2.276","article-title":"Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophages","volume":"15","author":"Kritharides","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib23","doi-asserted-by":"crossref","first-page":"34508","DOI":"10.1074\/jbc.M006738200","article-title":"ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages","volume":"275","author":"Oram","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib24","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0003-2697(77)90043-4","article-title":"A simplification of the protein assay method of Lowry et al. which is more generally applicable","volume":"83","author":"Peterson","year":"1977","journal-title":"Anal Biochem"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib25","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1194\/jlr.M300224-JLR200","article-title":"Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression","volume":"44","author":"Thorngate","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib26","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1194\/jlr.M400133-JLR200","article-title":"SR-BI- and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndrome","volume":"45","author":"Yancey","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib27","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1161\/01.ATV.14.7.1056","article-title":"A cell culture system for screening human serum for ability to promote cellular cholesterol efflux. Relations between serum components and efflux, esterification, and transfer","volume":"14","author":"de la Llera Moya","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0021-9150(99)00188-4","article-title":"Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes","volume":"147","author":"Fournier","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/01.ATV.0000203515.25574.19","article-title":"Relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages","volume":"26","author":"Duong","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib30","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1172\/JCI32057","article-title":"Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo","volume":"117","author":"Wang","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1388-1981(00)00146-3","article-title":"Cholesterol and phospholipid metabolism in macrophages","volume":"1529","author":"Tabas","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib32","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1016\/j.febslet.2005.10.042","article-title":"Impaired ATP-binding cassette transporter A1-mediated sterol efflux from oxidized LDL-loaded macrophages","volume":"579","author":"Favari","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/01.mol.0000226116.35555.eb","article-title":"Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages","volume":"17","author":"Jessup","year":"2006","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib34","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1194\/jlr.M300461-JLR200","article-title":"Sterol regulation of scavenger receptor class B type I in macrophages","volume":"45","author":"Yu","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib35","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1194\/jlr.M300100-JLR200","article-title":"Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR","volume":"44","author":"Khovidhunkit","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib36","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.M700274-JLR200","article-title":"The roles of different pathways in the release of cholesterol from macrophages","author":"Adorni","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib37","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0002-8703(87)90632-6","article-title":"Lipoprotein abnormalities in hypertriglyceridemia: significance in atherosclerosis","volume":"113","author":"Eisenberg","year":"1987","journal-title":"Am Heart J"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib38","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI115747","article-title":"Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques","volume":"89","author":"O\u2019Brien","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosis.2006.04.018","article-title":"Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR\/RXR responsive element","volume":"191","author":"Uehara","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2007.09.023_bib40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.atherosclerosis.2003.12.001","article-title":"Triglyceride-rich lipoproteins inhibit cholesterol efflux to apolipoprotein (apo) A1 from human macrophage foam cells","volume":"173","author":"Palmer","year":"2004","journal-title":"Atherosclerosis"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915007005631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915007005631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:30:38Z","timestamp":1758155438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915007005631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0021915007005631"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2007.09.023","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced removal of cholesterol from macrophage foam cells to serum from type IV hypertriglyceridemic subjects","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2007.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}