{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:07:45Z","timestamp":1788869265929,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013642","name":"Japan Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.atherosclerosis.2008.05.026","type":"journal-article","created":{"date-parts":[[2008,5,29]],"date-time":"2008-05-29T04:57:47Z","timestamp":1212037067000},"page":"51-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Vascular protective effects of ezetimibe in ApoE-deficient mice"],"prefix":"10.1016","volume":"203","author":[{"given":"Hironori","family":"Nakagami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Kiomy","family":"Osako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Takami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Hanayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Koriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib1","doi-asserted-by":"crossref","unstructured":"Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383\u20139.","DOI":"10.1016\/S0140-6736(94)90566-5"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev.nu.03.070183.000443","article-title":"Absorption and metabolism of dietary cholesterol","volume":"3","author":"Grundy","year":"1983","journal-title":"Annual Review of Nutrition"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-3565(24)36992-7","article-title":"In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461","volume":"283","author":"Van Heek","year":"1997","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1021\/jm970701f","article-title":"Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption","volume":"41","author":"Rosenblum","year":"1998","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0014-2999(01)00825-1","article-title":"The cholesterol absorption inhibitor, ezetimibe, decreases diet-induced hypercholesterolemia in monkeys","volume":"415","author":"van Heek","year":"2001","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib6","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1126\/science.1093131","article-title":"Niemann\u2013Pick C1 Like 1 protein is critical for intestinal cholesterol absorption","volume":"303","author":"Altmann","year":"2004","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib7","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1073\/pnas.0500269102","article-title":"The target of ezetimibe is Niemann\u2013Pick C1-Like 1 (NPC1L1)","volume":"102","author":"Garcia-Calvo","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5551\/jat.14.99","article-title":"Zetia: inhibition of Niemann\u2013Pick C1 Like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia","volume":"14","author":"Davis","year":"2007","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib9","doi-asserted-by":"crossref","first-page":"33586","DOI":"10.1074\/jbc.M405817200","article-title":"Niemann\u2013Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis","volume":"279","author":"Davis","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.ATV.0000257627.40486.46","article-title":"Deficiency of Niemann\u2013Pick C1 Like 1 prevents atherosclerosis in ApoE\u2212\/\u2212 mice","volume":"27","author":"Davis","year":"2007","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib11","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/sj.gt.3301284","article-title":"In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model","volume":"7","author":"Hayashi","year":"2000","journal-title":"Gene Therapy"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib12","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nm1574","article-title":"The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress","volume":"13","author":"Nakai","year":"2007","journal-title":"Nature Medicine"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib13","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1172\/JCI200111927","article-title":"p47phox is required for atherosclerotic lesion progression in ApoE(\u2212\/\u2212) mice","volume":"108","author":"Barry-Lane","year":"2001","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib14","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/hq1201.100260","article-title":"Ezetimibe a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in ApoE knockout mice","volume":"21","author":"Davis","year":"2001","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJM199502233320801","article-title":"Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease","volume":"332","author":"Treasure","year":"1995","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1050-1738(00)00044-X","article-title":"Direct vascular effects of HMG-CoA reductase inhibitors","volume":"10","author":"Laufs","year":"2000","journal-title":"Trends in Cardiovascular Medicine"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib17","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1016\/j.jacc.2006.01.073","article-title":"Increased activity of the ubiquitin\u2013proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment","volume":"47","author":"Marfella","year":"2006","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib18","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1161\/01.ATV.0000232501.08576.73","article-title":"Dysregulation of the ubiquitin\u2013proteasome system in human carotid atherosclerosis","volume":"26","author":"Versari","year":"2006","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0008-6363(03)00296-7","article-title":"Downregulation of eNOS mRNA expression by TNFalpha: identification and functional characterization of RNA-protein interactions in the 3\u2032UTR","volume":"59","author":"Lai","year":"2003","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib20","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1074\/jbc.M309552200","article-title":"Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells","volume":"279","author":"Anderson","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib21","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1016\/j.febslet.2007.11.023","article-title":"Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome","volume":"581","author":"Deushi","year":"2007","journal-title":"FEBS Letters"},{"key":"10.1016\/j.atherosclerosis.2008.05.026_bib22","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.3748\/wjg.v12.i27.4369","article-title":"Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease","volume":"12","author":"Assy","year":"2006","journal-title":"World Journal of Gastroenterology"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915008003614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915008003614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:29:20Z","timestamp":1758155360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915008003614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0021915008003614"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2008.05.026","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular protective effects of ezetimibe in ApoE-deficient mice","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2008.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}