{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:08:49Z","timestamp":1773270529244,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.atherosclerosis.2009.01.013","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T09:25:19Z","timestamp":1232616319000},"page":"512-516","source":"Crossref","is-referenced-by-count":26,"title":["Fc\u03b3RIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease"],"prefix":"10.1016","volume":"205","author":[{"given":"Dorette","family":"Raaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif B.","family":"Ekici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Klinghammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Lausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard E.","family":"Voll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette H.W.","family":"Leusen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G.J.","family":"van de Winkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner G.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph D.","family":"Garlichs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis is an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib2","doi-asserted-by":"crossref","first-page":"C19","DOI":"10.1016\/j.jacc.2005.10.066","article-title":"C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients","volume":"47","author":"Tsimikas","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib3","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1084\/jem.190.12.1733","article-title":"C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction","volume":"190","author":"Griselli","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1172\/JCI7817","article-title":"C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific","volume":"105","author":"Stein","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1084\/jem.172.1.19","article-title":"Molecular basis for a polymorphism of human Fc gamma receptor II (CD32)","volume":"172","author":"Warmerdam","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/art.10930","article-title":"Identification of IgG subclasses and C-reactive protein in lupus nephritis: the relationship between the composition of immune deposits and FCgamma receptor type IIA alleles","volume":"48","author":"Zuniga","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib8","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1002\/art.11059","article-title":"Role of the Fcgamma receptor IIA polymorphism in the antiphospholipid syndrome: an international meta-analysis","volume":"48","author":"Karassa","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1034\/j.1399-0039.2003.00037.x","article-title":"FcgammaR polymorphisms: implications for function, disease susceptibility and immunotherapy","volume":"61","author":"van Sorge","year":"2003","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib10","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1136\/ard.61.9.786","article-title":"Fcgamma receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms","volume":"61","author":"Manger","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib11","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1161\/01.RES.0000250556.07796.6c","article-title":"Fc\u03b3 receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice","volume":"99","author":"Hern\u00e1ndez-Vargas","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib12","first-page":"1598","article-title":"Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes","volume":"13","author":"Bassand","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib13","first-page":"2525","article-title":"Universal definition of myocardial infarction","volume":"20","author":"Thygesen","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib14","first-page":"1341","article-title":"Guidelines on the management of stable angina pectoris: executive summary: the Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology","volume":"11","author":"Fox","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1749-6632.1997.tb52070.x","article-title":"Clinical relevance of Fc gamma receptor polymorphisms","volume":"815","author":"Rascu","year":"1997","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib16","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1182\/blood.V92.5.1526","article-title":"Heparin-induced thrombocytopenia: new insights into the impact of the Fcgamma RIIa-R-H131 polymorphism","volume":"92","author":"Carlsson","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib17","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1084\/jem.190.4.585","article-title":"The major receptor for C-reactive protein on leukocytes is Fcgamma receptor II","volume":"190","author":"Bharadwaj","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib18","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/01.CIR.98.8.731","article-title":"Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women","volume":"98","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib19","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMoa032804","article-title":"C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease","volume":"350","author":"Danesh","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib20","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/CIRCULATIONAHA.105.591271","article-title":"Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level","volume":"113","author":"Kathiresan","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib21","doi-asserted-by":"crossref","first-page":"e1395","DOI":"10.1371\/journal.pone.0001395","article-title":"C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case\u2013control studies","volume":"1","author":"Pai","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib22","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1056\/NEJMoa0707402","article-title":"Genetically elevated C-reactive protein and ischemic vascular disease","volume":"359","author":"Zacho","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib23","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMe0807235","article-title":"Elevated C-reactive protein in atherosclerosis\u2014chicken or egg?","volume":"359","author":"Schunkert","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib24","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1055\/s-0037-1613428","article-title":"Fc\u03b3 RIIa-R131H polymorphism: its impact on coronary heart disease in a German cohort","volume":"90","author":"Gardemann","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.atherosclerosis.2004.12.011","article-title":"Fc\u03b3 receptor IIIA polymorphism as a risk-factor for coronary artery disease","volume":"180","author":"Gavasso","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib26","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1161\/01.ATV.0000168573.10844.ae","article-title":"Binding and internalization of C-reactive protein by Fcgamma receptors on human aortic endothelial cells mediates biological effects","volume":"7","author":"Devaraj","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib27","doi-asserted-by":"crossref","first-page":"H1170","DOI":"10.1152\/ajpheart.00150.2006","article-title":"CRP promotes monocyte\u2013endothelial cell adhesion via Fc\u03b3 receptors in human aortic endothelial cells under static and shear flow conditions","volume":"291","author":"Devaraj","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib28","first-page":"2135","article-title":"Is C-reactive protein an innocent bystander or proatherogenic culprit? C-reactive protein promotes atherothrombosis","volume":"113","author":"Verma","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib29","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1189\/jlb.0208123","article-title":"C-reactive protein (CRP) induces chemokine secretion via CD11b\/ICAM-1 interaction in human adherent monocytes","volume":"84","author":"Montecucco","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib30","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1161\/01.CIR.0000015126.83143.B4","article-title":"Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein","volume":"105","author":"Verma","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.atherosclerosis.2007.03.003","article-title":"C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: implications for the destabilization of atherosclerotic plaque","volume":"196","author":"Nabata","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib32","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1194\/jlr.M700535-JLR200","article-title":"Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats","volume":"49","author":"Singh","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.atherosclerosis.2008.05.060","article-title":"C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo","volume":"203","author":"Devaraj","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJMoa012295","article-title":"Widespread coronary inflammation in unstable angina","volume":"347","author":"Buffon","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jacc.2006.07.071","article-title":"Persistent activation of nuclear factor kappa-B signaling pathway in patients with unstable angina and elevated levels of C-reactive protein evidence for a direct proinflammatory effect of azide and lipopolysaccharide-free C-reactive protein on human monocytes via nuclear factor kappa-B activation","volume":"49","author":"Liuzzo","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.atherosclerosis.2004.03.018","article-title":"Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease","volume":"175","author":"Hillyard","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2009.01.013_bib37","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1160\/TH06-08-0467","article-title":"C-reactive protein and Fc gamma RIIa functional polymorphisms are not associated with clinical presentation of stable and unstable angina","volume":"97","author":"Murphy","year":"2007","journal-title":"Thromb Haemost"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009000562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009000562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T22:48:21Z","timestamp":1589496501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915009000562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0021915009000562"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2009.01.013","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}