{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:40:52Z","timestamp":1790872852299,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.atherosclerosis.2009.01.035","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T16:37:59Z","timestamp":1233765479000},"page":"40-46","source":"Crossref","is-referenced-by-count":29,"title":["S-homocysteinylated LDL apolipoprotein B adversely affects human endothelial cells in vitro"],"prefix":"10.1016","volume":"206","author":[{"given":"Angelo","family":"Zinellu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Sotgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastianina","family":"Scanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Pintus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Posadino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Cossu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Deiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciriaco","family":"Carru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM199707243370403","article-title":"Plasma homocysteine levels and mortality in patients with coronary artery disease","volume":"337","author":"Nygard","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib2","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0735-1097(00)00820-2","article-title":"Elevated homocysteine levels are associated with increased ischemic myocardial injury in acute coronary syndromes","volume":"36","author":"Al-Obaidi","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0002-9149(00)01025-0","article-title":"Increased plasma homocysteine is an independent predictor of new atherothrombotic brain infarction in older persons","volume":"86","author":"Aronow","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0002-9149(00)00931-0","article-title":"Increased plasma homocysteine is an independent predictor of new coronary events in older persons","volume":"86","author":"Aronow","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0021-9150(90)90165-F","article-title":"Homocysteine and lipid metabolism in atherogenesis: effect of the homocysteine thiolactonyl derivatives, thioretinaco and thioretinamide","volume":"83","author":"McCully","year":"1990","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0021-9150(91)90257-4","article-title":"Homocysteine content of lipoproteins in hypercholesterolemia","volume":"88","author":"Olszewski","year":"1991","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib7","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1096\/fasebj.13.15.2277","article-title":"Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels","volume":"13","author":"Jakubowski","year":"1999","journal-title":"FASEB J"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib8","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S0891-5849(98)00287-1","article-title":"Characterization of the adduct formed from the reaction between homocysteine-thiolactone and low-density lipoprotein: antioxidant implications","volume":"26","author":"Ferguson","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib9","first-page":"25","article-title":"Protective effect of human HDL against Cu2+ induced oxidation of astrocytes","volume":"17","author":"Ferretti","year":"2003","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib10","first-page":"477","article-title":"Chemical pathology of homocysteine. I. Atherogenesis","volume":"23","author":"McCully","year":"1993","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib11","first-page":"70","article-title":"Thiolation of low-density lipoprotein by homocysteine thiolactone causes increased aggregation and altered interaction with cultured macrophages","volume":"4","author":"Naruszewicz","year":"1994","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/bies.950160212","article-title":"Atherosclerosis and glycation","volume":"16","author":"Colaco","year":"1994","journal-title":"Bioessays"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib13","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1172\/JCI117776","article-title":"Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells","volume":"95","author":"Khan","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1515\/CCLM.2000.023","article-title":"Oxidized lipoproteins and endothelium","volume":"38","author":"Pirillo","year":"2000","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1388-1981(02)00343-8","article-title":"Oxidized low density lipoprotein-induced apoptosis","volume":"1585","author":"Salvayre","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib16","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.sbi.2004.09.012","article-title":"The role of cysteine residues as redox-sensitive regulatory switches","volume":"14","author":"Barford","year":"2004","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib17","doi-asserted-by":"crossref","first-page":"46896","DOI":"10.1074\/jbc.M108451200","article-title":"Relative roles of albumin and ceruloplasmin in the formation of homocystine, homocysteine\u2013cysteine-mixed disulfide, and cystine in circulation","volume":"276","author":"Sengupta","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib18","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/01.ATV.0000023899.93940.7C","article-title":"Homocysteine binds to human plasma fibronectin and inhibits its interaction with fibrin","volume":"22","author":"Majors","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib19","doi-asserted-by":"crossref","first-page":"49707","DOI":"10.1074\/jbc.M306748200","article-title":"In vitro and in vivo interactions of homocysteine with human plasma transthyretin","volume":"278","author":"Lim","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib20","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.1074\/jbc.273.16.9987","article-title":"Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine","volume":"273","author":"Hajjar","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib21","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1074\/jbc.M004124200","article-title":"Homocysteine inhibits inactivation of factor Va by activated protein C","volume":"276","author":"Undas","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib22","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1006\/bbrc.1999.1391","article-title":"Influence of homocysteine on matrix metalloproteinase-2: activation and activity","volume":"263","author":"Bescond","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0009-3084(94)90128-7","article-title":"Primary structure of apoB-100","volume":"67\/68","author":"Yang","year":"1994","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib24","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1373\/clinchem.2006.071142","article-title":"Factors affecting S-homocysteinylation of LDL apoprotein B","volume":"52","author":"Zinellu","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib25","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1002\/elps.200500762","article-title":"Distribution of low-density lipoprotein-bound low-molecular-weight thiols: a new analytical approach","volume":"27","author":"Zinellu","year":"2006","journal-title":"Electrophoresis"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib26","first-page":"137","article-title":"Low density lipoprotein for oxidation and metabolic studies. Isolation from small volumes of plasma using a tabletop ultracentrifuge","volume":"65","author":"Himber","year":"1995","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/000456329503200206","article-title":"A rapid method for measurement of the susceptibility to oxidation of low-density lipoprotein","volume":"32","author":"McDowell","year":"1995","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib28","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0008-6363(03)00526-1","article-title":"PKC\/Raf\/MEK\/ERK signaling pathway modulates native-LDL-induced E2F-1 gene expression and endothelial cell proliferation","volume":"59","author":"Pintus","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib29","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1161\/01.RES.72.5.958","article-title":"Identification of functional PGH2\/TxA2 receptors on human endothelial cells","volume":"72","author":"Kent","year":"1993","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib30","doi-asserted-by":"crossref","first-page":"30111","DOI":"10.1074\/jbc.M104324200","article-title":"Albumin thiolate anion is an intermediate in the formation of albumin-S-S-homocysteine","volume":"276","author":"Sengupta","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jcb.20069","article-title":"Effect of homocysteinylation of low density lipoproteins on lipid peroxidation of human endothelial cells","volume":"92","author":"Ferretti","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib32","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/prot.21846","article-title":"Predicting protein homocysteinylation targets based on dihedral strain energy and pKa of cysteines","volume":"71","author":"Sundaramoorthy","year":"2008","journal-title":"Proteins"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib33","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1373\/clinchem.2004.043943","article-title":"Quantification of thiol-containing amino acids linked by disulfides to LDL","volume":"51","author":"Zinellu","year":"2005","journal-title":"Clin Chem"},{"issue":"16 (April)","key":"10.1016\/j.atherosclerosis.2009.01.035_bib34","doi-asserted-by":"crossref","first-page":"15518","DOI":"10.1074\/jbc.M501452200","article-title":"Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation","volume":"280","author":"Handy","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-5793(82)80388-8","article-title":"Superoxide-dependent formation of hydroxyl radicals in the presence of thiol compounds","volume":"138","author":"Rowley","year":"1982","journal-title":"FEBS Lett"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/jn\/130.2.369S","article-title":"Homocysteine and endothelial dysfunction: a link with cardiovascular disease","volume":"130","author":"McDowell","year":"2000","journal-title":"J Nutr"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib37","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI112442","article-title":"Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine","volume":"77","author":"Starkebaum","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/bj3320213","article-title":"Characterization of the stress-inducing effects of homocysteine","volume":"332","author":"Outinen","year":"1998","journal-title":"Biochem J"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib39","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1046\/j.0014-2956.2001.02460.x","article-title":"Homocysteine-induced decrease in endothelin-1 production is initiated at the extracellular level and involves oxidative products","volume":"268","author":"Drunat","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib40","first-page":"20","article-title":"Study on the oxidative injury of ECV304 cell induced by homocysteine","volume":"32","author":"Gao","year":"2003","journal-title":"Wei Sheng Yan Jiu"},{"key":"10.1016\/j.atherosclerosis.2009.01.035_bib41","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0021-9150(77)90177-0","article-title":"The distribution of labelled low-density lipoprotein across the rabbit thoracic aorta in vivo","volume":"28","author":"Bratzler","year":"1977","journal-title":"Atherosclerosis"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009000811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009000811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T20:19:14Z","timestamp":1558124354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915009000811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0021915009000811"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2009.01.035","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}