{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:51:56Z","timestamp":1789185116745,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.atherosclerosis.2009.06.014","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T08:22:59Z","timestamp":1245399779000},"page":"43-49","source":"Crossref","is-referenced-by-count":13,"title":["Cyclooxygenase-2 derived thromboxane A2 and reactive oxygen species mediate flow-induced constrictions of venules in hyperhomocysteinemia"],"prefix":"10.1016","volume":"208","author":[{"given":"Anita","family":"Racz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Veresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Lotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Bagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-0037-1614438","article-title":"Hyperhomocysteinemia, atherosclerosis and thrombosis","volume":"81","author":"Cattaneo","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1056\/NEJM199603213341203","article-title":"Hyperhomocysteinemia as a risk factor for deep-vein thrombosis","volume":"334","author":"den Heijer","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM199707243370403","article-title":"Plasma homocysteine levels and mortality in patients with coronary artery disease","volume":"337","author":"Nygard","year":"1997","journal-title":"N Engl J Med"},{"issue":"Suppl. 1","key":"10.1016\/j.atherosclerosis.2009.06.014_bib4","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/sj.cdd.4401451","article-title":"Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease","volume":"11","author":"Austin","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib5","first-page":"111","article-title":"Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully","year":"1969","journal-title":"Am J Pathol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0002-9440(10)64166-1","article-title":"Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation","volume":"161","author":"Ungvari","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib7","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1161\/01.ATV.13.9.1327","article-title":"Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells","volume":"13","author":"Fryer","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib8","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1172\/JCI115514","article-title":"Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine","volume":"88","author":"Lentz","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib9","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1161\/01.STR.0000132570.24618.78","article-title":"Hyperhomocysteinemia, low folate and vitamin B12 concentrations, and methylene tetrahydrofolate reductase mutation in cerebral venous thrombosis","volume":"35","author":"Cantu","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib10","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1007\/s10620-005-3064-0","article-title":"Portal vein thrombosis due to hyperhomocysteinemia caused by vitamin B-12 deficiency","volume":"50","author":"Kanbay","year":"2005","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib11","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1160\/TH05-06-1333","article-title":"Splenic thrombosis in three patients with moderate hyperhomocysteinemia, low folate and the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene","volume":"94","author":"Starakis","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib12","first-page":"249","article-title":"Retinal vein occlusion and hyperhomocysteinemia","volume":"26","author":"Blondel","year":"2003","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib13","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/01.ATV.20.5.1203","article-title":"Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia","volume":"20","author":"Ungvari","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/01.RES.72.3.607","article-title":"Coronary venular responses to flow and pressure","volume":"72","author":"Kuo","year":"1993","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib15","first-page":"H831","article-title":"Flow-induced responses in skeletal muscle venules: modulation by nitric oxide and prostaglandins","volume":"275","author":"Koller","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib16","doi-asserted-by":"crossref","first-page":"A846","DOI":"10.1096\/fasebj.21.6.A846-d","article-title":"Increased role of prostaglandin H-2\/thromboxane A(2) (PGH(2)\/TXA(2)) in mediation of flow dependent responses of gracilis muscle venules in hyperhomocysteinemia (HHcy)","volume":"21","author":"Racz","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/hq0102.101127","article-title":"Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite","volume":"22","author":"Bagi","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib18","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/01.ATV.0000061735.85377.40","article-title":"Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase","volume":"23","author":"Ungvari","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib19","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/hc3501.095287","article-title":"Oxidative stress and platelet activation in homozygous homocystinuria","volume":"104","author":"Davi","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib20","first-page":"R1571","article-title":"Gender difference in flow-induced dilation and regulation of shear stress: role of estrogen and nitric oxide","volume":"275","author":"Huang","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.HYP.31.1.309","article-title":"Estrogen preserves regulation of shear stress by nitric oxide in arterioles of female hypertensive rats","volume":"31","author":"Huang","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib22","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1055\/s-2006-951456","article-title":"Hyperhomocysteinemia and venous thromboembolism","volume":"32","author":"Cattaneo","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/01.CIR.97.5.437","article-title":"Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease.","volume":"97","author":"Robinson","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","article-title":"Homocysteine metabolism","volume":"19","author":"Selhub","year":"1999","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib25","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.clnu.2008.08.010","article-title":"Lack of effect of diet-induced hypomethylation on endothelium-dependent relaxation in rats","volume":"27","author":"Hirsch","year":"2008","journal-title":"Clin Nutr"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib26","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1021\/jm0613166","article-title":"Structural and functional basis of cyclooxygenase inhibition","volume":"50","author":"Blobaum","year":"2007","journal-title":"J Med Chem"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib27","doi-asserted-by":"crossref","first-page":"H1404","DOI":"10.1152\/ajpheart.00235.2003","article-title":"Superoxide-NO interaction decreases flow- and agonist-induced dilations of coronary arterioles in Type 2 diabetes mellitus","volume":"285","author":"Bagi","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib28","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.100.11.1161","article-title":"Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans","volume":"100","author":"Kanani","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib29","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0021-9258(19)42810-X","article-title":"Generation of superoxide free radical during the autooxidation of thiols","volume":"249","author":"Misra","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1389200052997357","article-title":"Mechanisms of increased vascular oxidant stress in hyperhomocys-teinemia and its impact on endothelial function","volume":"6","author":"Weiss","year":"2005","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib31","first-page":"A1400","article-title":"Hydrogen peroxide elicits prostaglandins-mediated constriction of isolated skeletal muscle venules","volume":"20","author":"Goetschkes","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib32","first-page":"H401","article-title":"Postischemic generation of superoxide anion by newborn pig brain","volume":"255","author":"Armstead","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib33","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1161\/01.RES.59.6.612","article-title":"PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH","volume":"59","author":"Kukreja","year":"1986","journal-title":"Circ Res"},{"issue":"Pt 1","key":"10.1016\/j.atherosclerosis.2009.06.014_bib34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/bj3320213","article-title":"Characterization of the stress-inducing effects of homocysteine","volume":"332","author":"Outinen","year":"1998","journal-title":"Biochem J"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-5793(00)02260-2","article-title":"Effects of homocysteine on the binding of extracellular-superoxide dismutase to the endothelial cell surface","volume":"486","author":"Yamamoto","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib36","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI112442","article-title":"Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine","volume":"77","author":"Starkebaum","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI118771","article-title":"Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia","volume":"98","author":"Lentz","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib38","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1096\/fasebj.11.13.9367351","article-title":"Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats","volume":"11","author":"Durand","year":"1997","journal-title":"FASEB J"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib39","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0021-9150(99)00260-9","article-title":"Endothelial dysfunction during acute methionine load in hyperhomocysteinaemic patients","volume":"147","author":"Constans","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1172\/JCI108520","article-title":"Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis","volume":"58","author":"Harker","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2009.06.014_bib41","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/0140-6736(91)92373-A","article-title":"Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway","volume":"338","author":"Surtees","year":"1991","journal-title":"Lancet"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009004870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009004870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T15:25:51Z","timestamp":1633620351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915009004870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0021915009004870"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2009.06.014","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}