{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:14:15Z","timestamp":1790856855870,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.atherosclerosis.2009.08.016","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T04:16:31Z","timestamp":1250741791000},"page":"490-495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":109,"title":["The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome"],"prefix":"10.1016","volume":"208","author":[{"given":"Luciano F.","family":"Drager","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A.","family":"Bortolotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"Maki-Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivani C.","family":"Trombetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Janieire N.N.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffael F.","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Negr\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo M.","family":"Krieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo","family":"Lorenzi-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib1","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.atherosclerosis.2008.08.029","article-title":"Metabolic syndrome and carotid intima media thickness in the Health 2000 Survey","volume":"204","author":"Sipil\u00e4","year":"2009","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.atherosclerosis.2009.08.016_bib3","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.2337\/dc07-1042","article-title":"Insulin resistance, metabolic syndrome, and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"30","author":"Bertoni","year":"2007","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2009.08.016_bib4","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1097\/HJH.0b013e3280a94e76","article-title":"Clustering of metabolic syndrome risk factors and arterial stiffness in young adults: the Northern Ireland Young Hearts Project","volume":"25","author":"Ferreira","year":"2007","journal-title":"J Hypertens"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2009.08.016_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/0003319706295477","article-title":"Arterial stiffness: determinants and relationship to the metabolic syndrome","volume":"58","author":"Achimastos","year":"2007","journal-title":"Angiology"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jacc.2005.04.046","article-title":"Increased subclinical atherosclerosis in young adults with metabolic syndrome: the Bogalusa Heart Study","volume":"46","author":"Tzou","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","article-title":"Metabolic syndrome\u2014a new world-wide definition. A Consensus Statement from the International Diabetes Federation","volume":"23","author":"Alberti","year":"2006","journal-title":"Diabetes Med"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib8","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2337\/diacare.29.04.06.dc05-2011","article-title":"Adult Treatment Panel III 2001 but not International Diabetes Federation 2005 criteria of the metabolic syndrome predict clinical cardiovascular events in subjects who underwent coronary angiography","volume":"29","author":"Saely","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib9","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1152\/japplphysiol.00772.2005","article-title":"Pathogenesis of obstructive sleep apnea","volume":"99","author":"Ryan","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib10","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ehj.2004.02.021","article-title":"Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome","volume":"25","author":"Coughlin","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1475-2840-5-22","article-title":"Obstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance state","volume":"5","author":"Gruber","year":"2006","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib12","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)71141-7","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnea with or without treatment with continuous positive airway pressure: an observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib13","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1056\/NEJMoa043104","article-title":"Obstructive sleep apnea as a risk factor for stroke and death","volume":"353","author":"Yaggi","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib14","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1378\/chest.06-1807","article-title":"Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome","volume":"131","author":"Kono","year":"2007","journal-title":"Chest"},{"issue":"Suppl 3","key":"10.1016\/j.atherosclerosis.2009.08.016_bib15","first-page":"S25","article-title":"\u201cSyndrome Z\u201d: the interaction of sleep apnoea, vascular risk factors and heart disease","volume":"53","author":"Wilcox","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/sleep\/32.5.615","article-title":"Empirical evidence for \u201cSyndrome Z\u201d: a hierarchical five-factor model of the metabolic syndrome incorporating sleep disturbance measures","volume":"32","author":"Nock","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib17","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1164\/rccm.200503-340OC","article-title":"Early signs of atherosclerosis in obstructive sleep apnea","volume":"172","author":"Drager","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib18","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1164\/rccm.200703-500OC","article-title":"Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea","volume":"176","author":"Drager","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib19","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1378\/chest.06-2703","article-title":"Obstructive sleep apnea, hypertension, and their interaction on arterial stiffness and heart remodeling","volume":"131","author":"Drager","year":"2007","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2009.08.016_bib20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1161\/HYPERTENSIONAHA.108.119420","article-title":"Additive effects of obstructive sleep apnea and hypertension on early markers of carotid atherosclerosis","volume":"53","author":"Drager","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness. The Epworth Sleepiness Scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib22","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/hy1101.096802","article-title":"Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans","volume":"38","author":"Hanon","year":"2001","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2009.08.016_bib23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/01.HYP.26.3.485","article-title":"Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies","volume":"26","author":"Asmar","year":"1995","journal-title":"Hypertension"},{"issue":"part 2","key":"10.1016\/j.atherosclerosis.2009.08.016_bib24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.HYP.34.4.837","article-title":"Plasma homocysteine, aortic stiffness, and renal function in hypertensive patients","volume":"34","author":"Bortolotto","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib25","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1164\/rccm.200703-458ED","article-title":"Obstructive sleep apnea and atherosclerosis: a new paradigm","volume":"175","author":"Lorenzi-Filho","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib26","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1164\/rccm.200612-1771OC","article-title":"Chronic intermittent hypoxia induces atherosclerosis","volume":"175","author":"Savransky","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib27","unstructured":"Lorenzi-Filho G, Drager LF. Obstructive sleep apnea and atherosclerosis. In: Bradley TD, Floras JS, editors. Sleep Apnea: Implications in cardiovascular and cerebrovascular disease. New York, NY: Informa Healthcare; in press."},{"issue":"7","key":"10.1016\/j.atherosclerosis.2009.08.016_bib28","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1161\/01.STR.0000019123.47840.2D","article-title":"Carotid artery wall thickness in patients with obstructive sleep apnea syndrome","volume":"33","author":"Silvestrini","year":"2002","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2009.08.016_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/sleep\/27.1.129","article-title":"Obstructive sleep apnea and carotid-artery intima-media thickness","volume":"27","author":"Suzuki","year":"2004","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.atherosclerosis.2009.08.016_bib30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/sj.jhh.1002318","article-title":"Structural and functional arterial properties in patients with obstructive sleep apnoea syndrome and cardiovascular comorbidities","volume":"22","author":"Protogerou","year":"2008","journal-title":"J Hum Hypertens"},{"issue":"4","key":"10.1016\/j.atherosclerosis.2009.08.016_bib31","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1378\/chest.08-0556","article-title":"Effects of continuous positive airway pressure on cardiovascular risk profile in patients with severe obstructive sleep apnea and metabolic syndrome","volume":"134","author":"Dorkova","year":"2008","journal-title":"Chest"},{"issue":"16","key":"10.1016\/j.atherosclerosis.2009.08.016_bib32","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1161\/01.CIR.0000033824.02722.F7","article-title":"Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?","volume":"106","author":"Cruickshank","year":"2002","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.atherosclerosis.2009.08.016_bib33","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1001\/archinte.166.16.1716","article-title":"Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea","volume":"166","author":"Arzt","year":"2006","journal-title":"Arch Intern Med"},{"issue":"13","key":"10.1016\/j.atherosclerosis.2009.08.016_bib34","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1161\/CIRCULATIONAHA.106.659706","article-title":"High prevalence of sleep apnea syndrome in patients with long-term pacing: the European Multicenter Polysomnographic Study","volume":"115","author":"Garrigue","year":"2007","journal-title":"Circulation"},{"issue":"15","key":"10.1016\/j.atherosclerosis.2009.08.016_bib35","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.jacc.2006.12.046","article-title":"Influence of obstructive sleep apnea on mortality in patients with heart failure","volume":"49","author":"Wang","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib36","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.7326\/0003-4819-134-11-200106050-00007","article-title":"Treatment with continuous positive airway pressure is not effective in patients with sleep apnea but no daytime sleepiness: a randomized, controlled trial","volume":"134","author":"Barb\u00e9","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib37","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1183\/09031936.06.00062805","article-title":"Continuous positive airway pressure does not reduce blood pressure in nonsleepy hypertensive OSA patients","volume":"27","author":"Robinson","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib38","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1164\/rccm.200805-717OC","article-title":"Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea","volume":"178","author":"Kohler","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib39","first-page":"1071","article-title":"Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort","volume":"31","author":"Young","year":"2008","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.atherosclerosis.2009.08.016_bib40","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1164\/rccm.200808-1259ED","article-title":"Is the cardiovascular system the primary target of obstructive sleep apnea?","volume":"178","author":"Lorenzi-Filho","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"21","key":"10.1016\/j.atherosclerosis.2009.08.016_bib41","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert consensus document on arterial stiffness: methodological issues and clinical applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.atherosclerosis.2009.08.016_bib42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/CIRCULATIONAHA.106.628875","article-title":"Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis","volume":"115","author":"Lorenz","year":"2007","journal-title":"Circulation"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009006789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009006789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:19:46Z","timestamp":1762186786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915009006789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0021915009006789"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2009.08.016","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2009.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}