{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:52:08Z","timestamp":1770965528610,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.atherosclerosis.2009.11.019","type":"journal-article","created":{"date-parts":[[2009,11,21]],"date-time":"2009-11-21T10:22:14Z","timestamp":1258798934000},"page":"314-319","source":"Crossref","is-referenced-by-count":40,"title":["Thrombopoietin contributes to enhanced platelet activation in cigarette smokers"],"prefix":"10.1016","volume":"210","author":[{"given":"Enrico","family":"Lupia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ornella","family":"Bosco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Goffi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Poletto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Spatola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Cuccurullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Montrucchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.atherosclerosis.2009.01.007","article-title":"Cigarette smoking: an undertreated risk factor for cardiovascular disease","volume":"205","author":"Erhardt","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0002-8703(88)90648-5","article-title":"Cigarette smoking and hemostatic function","volume":"115","author":"FitzGerald","year":"1988","journal-title":"Am Heart J"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib3","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0735-1097(01)01583-2","article-title":"Augmented oxidative stress of platelets in chronic smokers. Mechanisms of impaired platelet-derived nitric oxide bioactivity and augmented platelet aggregability","volume":"38","author":"Takajo","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib4","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/89961","article-title":"Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis","volume":"7","author":"Heeschen","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib6","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1161\/01.ATV.17.10.2167","article-title":"Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects","volume":"17","author":"Tracy","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/hrt.78.3.273","article-title":"Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease","volume":"78","author":"Mendall","year":"1997","journal-title":"Heart"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib8","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1161\/01.CIR.0000127128.52679.E4","article-title":"Upregulation of the CD40\/CD40 ligand dyad and platelet\u2013monocyte aggregation in cigarette smokers","volume":"109","author":"Harding","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib9","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1182\/blood.V100.10.3457","article-title":"Recombinant human thrombopoietin: basic biology and evaluation of clinical studies","volume":"100","author":"Kuter","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib10","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1046\/j.1538-7836.2003.00273.x","article-title":"Thrombopoietin: a tool for understanding thrombopoiesis","volume":"1","author":"Kaushansky","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib11","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1182\/blood.V87.7.2762.bloodjournal8772762","article-title":"Effects of recombinant human megakaryocyte growth and development factor on platelet activation","volume":"87","author":"Montrucchio","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib12","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1182\/blood.V87.11.4664.bloodjournal87114664","article-title":"Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists","volume":"87","author":"Oda","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib13","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1006\/bbrc.2002.6759","article-title":"Thrombopoietin induces p-selectin expression on platelets and subsequent platelet\/leukocyte interactions","volume":"292","author":"Tibbles","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib14","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1182\/blood.V87.10.4068.bloodjournal87104068","article-title":"Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction","volume":"87","author":"Emmons","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib15","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1365-2141.1996.d01-1702.x","article-title":"Circulating thrombopoietin level in chronic immune thrombocytopenic purpura","volume":"93","author":"Kosugi","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib16","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/01.CCM.0000121433.61546.A0","article-title":"Sepsis severity is the major determinant of circulating thrombopoietin levels in septic patients","volume":"32","author":"Zakynthinos","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib17","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.jacc.2006.04.106","article-title":"Thrombopoietin contributes to enhanced platelet activation in patients with unstable angina","volume":"48","author":"Lupia","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib18","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/j.1538-7836.2009.03348.x","article-title":"Elevated thrombopoietin in plasma of burned patients without and with sepsis enhances platelet activation","volume":"50","author":"Lupia","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jacc.2004.10.061","article-title":"Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers","volume":"45","author":"Morita","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib20","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1055\/s-0037-1613944","article-title":"Platelets release thrombopoietin (Tpo) upon activation: another regulatory loop in thrombocytopoiesis?","volume":"83","author":"Folman","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib21","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1161\/01.CIR.0000017140.26466.F5","article-title":"Platelet\u2013monocyte aggregates: bridging thrombosis and inflammation","volume":"105","author":"Freedman","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib22","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/hc3801.095588","article-title":"Circulating monocyte\u2013platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction","volume":"104","author":"Michelson","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0021-9150(01)00570-6","article-title":"Particulate and vapor phase constituents of cigarette mainstream smoke and risk of myocardial infarction","volume":"158","author":"Smith","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1046\/j.1365-2141.1999.01571.x","article-title":"Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics","volume":"106","author":"Li","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib25","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood.V88.2.511.bloodjournal882511","article-title":"Dose\u2013response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates","volume":"88","author":"Harker","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib26","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.4049\/jimmunol.116.5.1289","article-title":"Effects of C-reactive protein on platelet function. I. Inhibition of platelet aggregation and release reactions","volume":"116","author":"Fiedel","year":"1976","journal-title":"J Immunol"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib27","first-page":"H679","article-title":"Involvement of hydrogen and lipid peroxides in acute tobacco smoking-induced platelet hyperactivity","volume":"268","author":"Blache","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1089\/10799900050023915","article-title":"Interleukin-6 increases thrombopoietin production in human hepatoma cells HepG2 and Hep3B","volume":"20","author":"Wolber","year":"2000","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib29","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1161\/CIRCULATIONAHA.105.560250","article-title":"Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin","volume":"113","author":"Li","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2009.11.019_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/cvr\/cvm026","article-title":"Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia\/reperfusion in rats","volume":"77","author":"Baker","year":"2008","journal-title":"Cardiovasc Res"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009009769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915009009769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T16:44:31Z","timestamp":1685205871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915009009769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0021915009009769"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2009.11.019","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}