{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:53:20Z","timestamp":1784375600148,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.atherosclerosis.2010.09.004","type":"journal-article","created":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T08:29:14Z","timestamp":1285144154000},"page":"573-578","source":"Crossref","is-referenced-by-count":47,"title":["High plasma levels of macrophage migration inhibitory factor are associated with adverse long-term outcome in patients with stable coronary artery disease and impaired glucose tolerance or type 2 diabetes mellitus"],"prefix":"10.1016","volume":"213","author":[{"given":"Aritaka","family":"Makino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsumasa","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Kitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Fujioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ei","family":"Obata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Kugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0005","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jacc.2005.03.074","article-title":"Atherothrombosis and high-risk plaque: part I: evolving concepts","volume":"46","author":"Fuster","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0010","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0015","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1161\/CIRCULATIONAHA.107.729125","article-title":"Macrophage migration inhibitory factor in cardiovascular disease","volume":"117","author":"Zernecke","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0020","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1161\/01.CIR.0000012942.49244.82","article-title":"Expression of macrophage migration inhibitory factor in different stages of human atherosclerosis","volume":"105","author":"Burger-Kentischer","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.atherosclerosis.2004.08.038","article-title":"The expression of macrophage migration inhibitory factor 1alpha (MIF 1alpha) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability","volume":"178","author":"Schmeisser","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0030","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.atherosclerosis.2004.08.030","article-title":"Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques","volume":"178","author":"Kong","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0035","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1089\/ars.2005.7.1195","article-title":"Up-regulation and coexpression of MIF and matrix metalloproteinases in human abdominal aortic aneurysms","volume":"7","author":"Verschuren","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0040","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.amjmed.2004.04.010","article-title":"Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study","volume":"117","author":"Boekholdt","year":"2004","journal-title":"Am J Med"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0045","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ncprheum0701","article-title":"Mechanisms of disease: macrophage migration inhibitory factor in SLE, RA and atherosclerosis","volume":"4","author":"Ayoub","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0050","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.atherosclerosis.2007.12.025","article-title":"Macrophage migration inhibitory factor (MIF) and risk for coronary heart disease: results from the MONICA\/KORA Augsburg case-cohort study, 1984\u20132002","volume":"200","author":"Herder","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0055","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s00125-008-1063-3","article-title":"The role of macrophage migration inhibitory factor on glucose metabolism and diabetes","volume":"51","author":"Toso","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0060","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2337\/diacare.29.02.06.dc05-1474","article-title":"Association of systemic concentrations of macrophage migration inhibitory factor with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg, Survey 4 (KORA S4)","volume":"29","author":"Herder","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0065","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s00125-002-0896-4","article-title":"Plasma concentrations of macrophage migration inhibitory factor are elevated in Pima Indians compared to Caucasians and are associated with insulin resistance","volume":"45","author":"Vozarova","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0070","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2337\/diacare.26.2007.S5","article-title":"Report of the expert committee on the diagnosis and classification of diabetes mellitus","volume":"26","author":"Expert Committee on the Diagnosis","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1006\/bbrc.1997.6745","article-title":"Identification of macrophage migration inhibitory factor in adipose tissue and its induction by tumor necrosis factor-alpha","volume":"235","author":"Hirokawa","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0080","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF03402125","article-title":"Regulation of macrophage migration inhibitory factor (MIF) expression by glucose and insulin in adipocytes in vitro","volume":"5","author":"Sakaue","year":"1999","journal-title":"Mol Med"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0085","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1073\/pnas.94.9.4782","article-title":"Insulin secretion is regulated by the glucose-dependent production of islet beta cell macrophage migration inhibitory factor","volume":"94","author":"Waeber","year":"1997","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0090","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/CIRCRESAHA.109.199166","article-title":"MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease","volume":"105","author":"Verschuren","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0095","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1161\/01.CIR.0000134704.84454.D2","article-title":"Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice","volume":"109","author":"Pan","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0100","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nm1567","article-title":"MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment","volume":"13","author":"Bernhagen","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.atherosclerosis.2005.03.028","article-title":"Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)","volume":"184","author":"Burger-Kentischer","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1820001","article-title":"Macrophage migration inhibitory factor: molecular, cellular and genetic aspects of a key neuroendocrine molecule","volume":"182","author":"Donn","year":"2004","journal-title":"J Endocrinol"},{"key":"10.1016\/j.atherosclerosis.2010.09.004_bib0115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.0818-9641.2002.01148.x","article-title":"Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator","volume":"81","author":"Petrovsky","year":"2003","journal-title":"Immunol Cell Biol"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002191501000732X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002191501000732X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:22:11Z","timestamp":1559694131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002191501000732X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S002191501000732X"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2010.09.004","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}