{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:25:42Z","timestamp":1791329142431,"version":"4.3.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.atherosclerosis.2011.06.023","type":"journal-article","created":{"date-parts":[[2011,6,26]],"date-time":"2011-06-26T00:05:07Z","timestamp":1309046707000},"page":"458-464","source":"Crossref","is-referenced-by-count":36,"title":["Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI"],"prefix":"10.1016","volume":"217","author":[{"given":"Bas J.M.","family":"Peters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmi","family":"Pett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf H.","family":"Klungel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno H. Ch.","family":"Stricker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Psaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Glazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri L.","family":"Wiggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh C.","family":"Bis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthonius","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke-Hilse","family":"Maitland-van der Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0005","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1365-2125.2003.02060.x","article-title":"Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes","volume":"57","author":"Cheung","year":"2004","journal-title":"Br J Clin Pharmacol"},{"issue":"8","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0010","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1586\/erc.09.83","article-title":"Genetic determinants of response to statins","volume":"7","author":"Peters","year":"2009","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/HJH.0b013e328317a74d","article-title":"Interaction between the Gly460Trp alpha-adducin gene variant and diuretics on the risk of myocardial infarction","volume":"27","author":"van Wieren-de Wijer","year":"2009","journal-title":"J Hypertens"},{"issue":"8","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0020","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2217\/pgs.10.81","article-title":"Pharmacogenetic interactions between ABCB1 and SLCO1B1 tagging SNPs and the effectiveness of statins in the prevention of myocardial infarction","volume":"11","author":"Peters","year":"2010","journal-title":"Pharmacogenomics"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0025","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s11096-008-9264-x","article-title":"Recruitment of participants through community pharmacies for a pharmacogenetic study of antihypertensive drug treatment","volume":"31","author":"van Wieren-de Wijer","year":"2009","journal-title":"Pharm World Sci"},{"issue":"7164","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0030","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nature06258","article-title":"A second generation human haplotype map of over 3.1 million SNPs","volume":"449","author":"Frazer","year":"2007","journal-title":"Nature"},{"issue":"Web Server issue","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0035","doi-asserted-by":"crossref","first-page":"W115","DOI":"10.1093\/nar\/gkm329","article-title":"QuickSNP: an automated web server for selection of tagSNPs","volume":"35","author":"Grover","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0040","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/nar\/29.1.308","article-title":"dbSNP: the NCBI database of genetic variation","volume":"29","author":"Sherry","year":"2001","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0045","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/archinte.154.12.1333","article-title":"The risk of myocardial infarction associated with the combined use of estrogens and progestins in postmenopausal women","volume":"154","author":"Psaty","year":"1994","journal-title":"Arch Intern Med"},{"issue":"8","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0050","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1001\/jama.274.8.620","article-title":"The risk of myocardial infarction associated with antihypertensive drug therapies","volume":"274","author":"Psaty","year":"1995","journal-title":"JAMA"},{"issue":"16","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0055","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9\u201310","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0060","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cca.2010.01.002","article-title":"Influence of SCARB1 polymorphisms on serum lipids of hypercholesterolemic individuals treated with atorvastatin","volume":"411","author":"Cerda","year":"2010","journal-title":"Clin Chim Acta"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0065","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng1161","article-title":"Mutations in PCSK9 cause autosomal dominant hypercholesterolemia","volume":"34","author":"Abifadel","year":"2003","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.tibs.2006.12.008","article-title":"Molecular biology of PCSK9: its role in LDL metabolism","volume":"32","author":"Horton","year":"2007","journal-title":"Trends Biochem Sci"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0075","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMoa054013","article-title":"Sequence variations in PCSK9, low LDL, and protection against coronary heart disease","volume":"354","author":"Cohen","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2011.06.023_bib0080","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2350-7-66","article-title":"The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women","volume":"7","author":"Evans","year":"2006","journal-title":"BMC Med Genet"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0085","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1515\/CCLM.2009.032","article-title":"The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan","volume":"47","author":"Hsu","year":"2009","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0090","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.atherosclerosis.2009.06.023","article-title":"Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles","volume":"208","author":"Norata","year":"2008","journal-title":"Atherosclerosis"},{"issue":"10","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0095","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.jacc.2005.01.051","article-title":"A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis","volume":"45","author":"Chen","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0100","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1086\/500615","article-title":"A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol","volume":"78","author":"Kotowski","year":"2006","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.atherosclerosis.2007.12.005","article-title":"Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population","volume":"200","author":"Polisecki","year":"2008","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/CS20070150","article-title":"The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men","volume":"113","author":"Scartezini","year":"2007","journal-title":"Clin Sci (Lond)"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0115","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/01.ATV.0000204337.81286.1c","article-title":"Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy","volume":"26","author":"Berge","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0120","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1136\/jmg.2006.038356","article-title":"Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk","volume":"43","author":"Humphries","year":"2006","journal-title":"J Med Genet"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0125","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1161\/01.ATV.0000190668.94752.ab","article-title":"Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response","volume":"25","author":"Naoumova","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/CIRCGENETICS.108.818062","article-title":"Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort","volume":"2","author":"Thompson","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0135","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00041433-200304000-00010","article-title":"Hepatic lipase: a marker for cardiovascular disease risk and response to therapy","volume":"14","author":"Zambon","year":"2003","journal-title":"Curr Opin Lipidol"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0140","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0002-9149(97)00965-X","article-title":"Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)","volume":"81","author":"Jones","year":"1998","journal-title":"Am J Cardiol"},{"issue":"10","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0145","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0165-6147(02)02077-1","article-title":"Statins as anti-inflammatory agents","volume":"23","author":"Weitz-Schmidt","year":"2002","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2011.06.023_bib0150","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0895-4356(97)00040-1","article-title":"Validation of pharmacy records in drug exposure assessment","volume":"50","author":"Lau","year":"1997","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.atherosclerosis.2011.06.023_bib0155","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1161\/ATVBAHA.109.188474","article-title":"Identification of genetic variants associated with response to statin therapy","volume":"29","author":"Mega","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915011005041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915011005041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T17:52:34Z","timestamp":1543686754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915011005041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0021915011005041"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2011.06.023","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}