{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:47:14Z","timestamp":1778960834381,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD06\/0009"],"award-info":[{"award-number":["RD06\/0009"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.atherosclerosis.2011.07.114","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T16:15:29Z","timestamp":1312647329000},"page":"368-372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biomarkers to predict clinical progression in small vessel disease strokes: Prognostic role of albuminuria and oxidized LDL cholesterol"],"prefix":"10.1016","volume":"219","author":[{"given":"Elisa","family":"Cuadrado-Godia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Ois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Garcia-Ramallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Giralt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Jimena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rodr\u00edguez-Campello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Jim\u00e9nez-Conde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Roquer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0005","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1586\/14737175.9.2.179","article-title":"Lacunar stroke","volume":"9","author":"Arboix","year":"2009","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0010","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/01.STR.0000016326.78014.FE","article-title":"Lacunar stroke is the major cause of progressive motor deficits","volume":"33","author":"Steinke","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0015","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1161\/01.STR.32.5.1154","article-title":"Neurological deterioration in acute lacunar infarctions: the role of excitatory and inhibitory neurotransmitters","volume":"32","author":"Serena","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0020","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1161\/hs0402.105339","article-title":"Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target","volume":"33","author":"Castellanos","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000077012","article-title":"Progression in lacunar stroke is related to elevated acute phase parameters","volume":"51","author":"Audebert","year":"2004","journal-title":"Eur Neurol"},{"issue":"Suppl. 1","key":"10.1016\/j.atherosclerosis.2011.07.114_bib0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000200439","article-title":"Endothelial dysfunction, vascular disease and stroke: the ARTICO study","volume":"27","author":"Roquer","year":"2009","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0035","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.STR.0000058480.77236.B3","article-title":"Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?","volume":"34","author":"Wardlaw","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0040","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1159\/000212672","article-title":"Endothelial dysfunction in lacunar stroke: a systematic review","volume":"27","author":"Knottnerus","year":"2009","journal-title":"Cerebrovasc Dis"},{"issue":"Suppl. 2","key":"10.1016\/j.atherosclerosis.2011.07.114_bib0045","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1097\/00005344-200606001-00009","article-title":"Microalbuminuria and endothelial dysfunction: emerging targets for primary prevention of end-organ damage","volume":"47","author":"Ochodnicky","year":"2006","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0050","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/j.1538-7836.2006.01949.x","article-title":"von Willebrand factor, endothelial dysfunction, and cardiovascular disease","volume":"4","author":"Vischer","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0055","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11892-007-0041-3","article-title":"Oxidative stress and endothelial dysfunction in vascular disease","volume":"7","author":"Pennathur","year":"2007","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0060","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/ana.20617","article-title":"An evidence-based causative classification system for acute ischemic stroke","volume":"58","author":"Ay","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0065","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1161\/STROKEAHA.109.548032","article-title":"High risk of early neurological recurrence in symptomatic carotid stenosis","volume":"40","author":"Ois","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0070","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1007\/s00415-008-0820-z","article-title":"Acute stroke unit care and early neurological deterioration in ischemic stroke","volume":"255","author":"Roquer","year":"2008","journal-title":"J Neurol"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1212\/WNL.52.1.29","article-title":"Progressive motor deficits in lacunar infarction","volume":"52","author":"Nakamura","year":"1999","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2011.07.114_bib0080","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.numecd.2008.12.017","article-title":"Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta","volume":"21","author":"Wong","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0085","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000151638","article-title":"Early neurological deterioration following intravenous recombinant tissue plasminogen activator therapy in patients with acute lacunar stroke","volume":"26","author":"Hwang","year":"2008","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0090","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2176\/nmc.35.663","article-title":"Clinical features of progressive lacunar infarction\u2014retrospective analysis of patients with motor syndromes","volume":"35","author":"Kitanaka","year":"1995","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0095","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/01.STR.0000109769.22917.B0","article-title":"Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome","volume":"35","author":"Castillo","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000091137","article-title":"The role of matrix metalloproteinase 9 in early neurological worsening of acute lacunar infarction","volume":"55","author":"Kim","year":"2006","journal-title":"Eur Neurol"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0105","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1161\/STROKEAHA.109.576223","article-title":"Endothelial activation in lacunar stroke subtypes","volume":"41","author":"Knottnerus","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0110","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1046\/j.1365-2796.2003.01280.x","article-title":"Microalbuminuria and oxidative stress in essential hypertension","volume":"255","author":"Giner","year":"2004","journal-title":"J Intern Med"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0115","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/ajh.2007.77","article-title":"Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama study","volume":"21","author":"Ishikawa","year":"2008","journal-title":"Am J Hypertens"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2011.07.114_bib0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/ars.2009.2733","article-title":"Oxidized LDL: diversity, patterns of recognition, and pathophysiology","volume":"13","author":"Levitan","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0125","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1212\/01.wnl.0000238353.89194.08","article-title":"Micro- and macroalbuminuria predict hemorrhagic transformation in acute ischemic stroke","volume":"67","author":"Rodriguez-Yanez","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.atherosclerosis.2011.07.114_bib0130","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1001\/archneur.55.4.481","article-title":"Different predictors of neurological worsening in different causes of stroke","volume":"55","author":"Yamamoto","year":"1998","journal-title":"Arch Neurol"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915011007350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915011007350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:21:20Z","timestamp":1762186880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915011007350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0021915011007350"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2011.07.114","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers to predict clinical progression in small vessel disease strokes: Prognostic role of albuminuria and oxidized LDL cholesterol","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2011.07.114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}