{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:39:23Z","timestamp":1791142763279,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.atherosclerosis.2012.01.040","type":"journal-article","created":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T23:31:37Z","timestamp":1328139097000},"page":"490-495","source":"Crossref","is-referenced-by-count":46,"title":["Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction"],"prefix":"10.1016","volume":"221","author":[{"given":"Tousei","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnichi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Naruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadako","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuro","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0005","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0010","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.192.4.565","article-title":"High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes","volume":"192","author":"Andersson","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0020","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2796.2003.01302.x","article-title":"Extracellular role of HMGB1 in inflammation and sepsis","volume":"255","author":"Wang","year":"2004","journal-title":"J Intern Med"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/cvr\/cvn163","article-title":"High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice","volume":"80","author":"Kitahara","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0030","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1253\/circj.72.1178","article-title":"Effects of HMGB1 on ischemia-reperfusion injury in the rat heart","volume":"72","author":"Oozawa","year":"2008","journal-title":"Circ J"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0035","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1189\/jlb.0607406","article-title":"HMGB1 preconditioning: therapeutic application for a danger signal?","volume":"83","author":"Klune","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0040","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1161\/01.ATV.0000145573.36113.8a","article-title":"Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines","volume":"24","author":"Kalinina","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cca.2009.06.016","article-title":"Increased serum HMGB1 is related to the severity of coronary artery stenosis","volume":"406","author":"Hu","year":"2009","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/ATVBAHA.110.218669","article-title":"High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice","volume":"31","author":"Kanellakis","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0055","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1161\/CIRCULATIONAHA.108.769331","article-title":"High-mobility group box-1 in ischemia-reperfusion injury of the heart","volume":"117","author":"Andrassy","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0060","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00395-010-0114-3","article-title":"HMGB1: the missing link between diabetes mellitus and heart failure","volume":"105","author":"Volz","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0065","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-0030-1251503","article-title":"The role of HMGB1\/RAGE in inflammatory cardiomyopathy","volume":"36","author":"Volz","year":"2010","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0070","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cca.2006.04.016","article-title":"New high mobility group box 1 assay system","volume":"372","author":"Yamada","year":"2006","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0075","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cvr\/cvn291","article-title":"Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling","volume":"81","author":"Kohno","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jcin.2010.10.015","article-title":"Plasma high-mobility group box 1 levels predict mortality after ST-segment elevation myocardial infarction","volume":"4","author":"Sorensen","year":"2011","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0085","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Revised equations for estimated GFR from serum creatinine in Japan","volume":"53","author":"Matsuo","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0090","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0735-1097(85)80384-3","article-title":"Angiographic morphology and the pathogenesis of unstable angina pectoris","volume":"5","author":"Ambrose","year":"1985","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0095","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0735-1097(02)02969-8","article-title":"Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: a GUSTO-IV substudy","volume":"41","author":"James","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0100","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/hrt.2009.174912","article-title":"Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: a meta-analysis of longitudinal studies","volume":"96","author":"He","year":"2010","journal-title":"Heart"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0105","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1164\/rccm.200402-188OC","article-title":"Contributions of high mobility group box protein in experimental and clinical acute lung injury","volume":"170","author":"Ueno","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0110","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0115","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s00268-005-0369-2","article-title":"Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis","volume":"30","author":"Suda","year":"2006","journal-title":"World J Surg"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0120","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.molimm.2004.09.028","article-title":"CRP after 2004","volume":"42","author":"Agrawal","year":"2005","journal-title":"Mol Immunol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10875-007-9126-7","article-title":"Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3","volume":"28","author":"Mantovani","year":"2008","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0130","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1161\/CIRCULATIONAHA.107.187397","article-title":"Universal definition of myocardial infarction","volume":"116","author":"Thygesen","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0135","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jacc.2009.04.033","volume":"54","author":"Hiro","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0140","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1161\/01.CIR.101.10.1102","article-title":"Major racial differences in coronary constrictor response between japanese and caucasians with recent myocardial infarction","volume":"101","author":"Pristipino","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0145","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0002-9149(79)90026-2","article-title":"Exertional angina pectoris caused by coronary arterial spasm: effects of various drugs","volume":"43","author":"Yasue","year":"1979","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2012.01.040_bib0150","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/01.CIR.65.2.281","article-title":"Exacerbation of vasotonic angina pectoris by propranolol","volume":"65","author":"Robertson","year":"1982","journal-title":"Circulation"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915012000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915012000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T17:26:04Z","timestamp":1543253164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915012000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0021915012000731"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.01.040","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}