{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:31:27Z","timestamp":1768411887714,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["126925"],"award-info":[{"award-number":["126925"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["121584"],"award-info":[{"award-number":["121584"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["124282"],"award-info":[{"award-number":["124282"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["129378"],"award-info":[{"award-number":["129378"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["117797"],"award-info":[{"award-number":["117797"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["41071"],"award-info":[{"award-number":["41071"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Social Insurance Institution of Finland"},{"name":"Turku University Hospital Medical Funds"},{"name":"Finnish Foundation of Cardiovascular Research"},{"name":"Turku University Foundation"},{"DOI":"10.13039\/501100005609","name":"Turku University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Juho Vainio Foundation"},{"name":"Lydia Maria Julin Foundation"},{"DOI":"10.13039\/501100007361","name":"Aarne and Aili Turunen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007361","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008484","name":"Paavo Nurmi Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008484","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003125","name":"Finnish Cultural Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004756","name":"Emil Aaltonen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sigrid Juselius Foundation"},{"DOI":"10.13039\/501100006706","name":"Tampere Tuberculosis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007083","name":"Orion-Farmos Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.atherosclerosis.2012.04.004","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T23:17:03Z","timestamp":1336605423000},"page":"474-479","source":"Crossref","is-referenced-by-count":32,"title":["Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6-year follow-up. The cardiovascular risk in Young Finns study"],"prefix":"10.1016","volume":"224","author":[{"given":"Juha","family":"Koskinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costan G.","family":"Magnussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma S.A.","family":"Viikari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"K\u00e4h\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomi","family":"Laitinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Hutri-K\u00e4h\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Jokinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli T.","family":"Raitakari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Juonala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1161\/CIRCULATIONAHA.104.502161","article-title":"Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the cardiovascular risk in young Finns study","volume":"112","author":"Juonala","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/01.HYP.32.1.170","article-title":"Quantification of alterations in structure and function of elastin in the arterial media","volume":"32","author":"Avolio","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib3","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/01.ATV.0000060460.52916.D6","article-title":"Noninvasive assessment of arterial stiffness and risk of atherosclerotic events","volume":"23","author":"Oliver","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib4","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/eurheartj\/ehm576","article-title":"Arterial structure and function in young adults with the metabolic syndrome: the cardiovascular risk in young Finns study","volume":"29","author":"Mattsson","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCULATIONAHA.109.886655","article-title":"Arterial stiffness and cardiovascular events: the Framingham heart study","volume":"121","author":"Mitchell","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib6","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/ATVBAHA.108.164582","article-title":"Distension of the carotid artery and risk of coronary events: the three-city study","volume":"28","author":"Leone","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib7","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/01.HYP.32.3.570","article-title":"Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease","volume":"32","author":"Blacher","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.atherosclerosis.2009.10.018","article-title":"Measurement of arterial distensibility and compliance to assess prognosis","volume":"209","author":"Haluska","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/CIRCULATIONAHA.109.894584","article-title":"Arterial structure and function after recovery from the metabolic syndrome: the cardiovascular risk in young Finns study","volume":"121","author":"Koskinen","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/01.HYP.0000130482.81883.fd","article-title":"Sex differences in age-related stiffening of the aorta in subjects with type 2 diabetes","volume":"44","author":"De Angelis","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib11","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1161\/CIRCULATIONAHA.105.541078","article-title":"Age- and gender-related ventricular-vascular stiffening: a community-based study","volume":"112","author":"Redfield","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib12","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1097\/00004872-200112000-00014","article-title":"Women exhibit a greater age-related increase in proximal aortic stiffness than men","volume":"19","author":"Waddell","year":"2001","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib13","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0735-1097(01)01166-4","article-title":"Comparative effects of aging in men and women on the properties of the arterial tree","volume":"37","author":"Smulyan","year":"2001","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib14","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib15","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.ultrasmedbio.2010.05.003","article-title":"Tracking of noninvasive ultrasound measurements of subclinical atherosclerosis in adulthood: findings from the cardiovascular risk in young Finns study","volume":"36","author":"Raiko","year":"2010","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib16","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1001\/archinte.160.7.898","article-title":"Overweight, obesity, and health risk. National task force on the prevention and treatment of obesity","volume":"160","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.HYP.26.2.355","article-title":"Arterial wall hypertrophy and stiffness in essential hypertensive patients","volume":"26","author":"Laurent","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/01.HYP.26.1.48","article-title":"Effects of hypertension on viscoelasticity of carotid and femoral arteries in humans","volume":"26","author":"Armentano","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCULATIONAHA.108.845065","article-title":"Conventional cardiovascular risk factors and metabolic syndrome in predicting carotid intima-media thickness progression in young adults: the cardiovascular risk in young Finns study","volume":"120","author":"Koskinen","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib20","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.CIR.97.10.996","article-title":"Insulin and risk of cardiovascular disease: a meta-analysis","volume":"97","author":"Ruige","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib21","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00125-004-1433-4","article-title":"Decode insulin study group. Plasma insulin and cardiovascular mortality in non-diabetic European men and women: a meta-analysis of data from eleven prospective studies","volume":"47","author":"Hu","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib22","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.2337\/diabetes.53.11.2735","article-title":"Molecular mechanisms of insulin resistance that impact cardiovascular biology","volume":"53","author":"Wang","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00041433-199608000-00008","article-title":"Insulin resistance and coronary heart disease","volume":"7","author":"Laakso","year":"1996","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib24","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/BF00402176","article-title":"Diabetes as a risk factor for stroke. A population perspective","volume":"38","author":"Stegmayr","year":"1995","journal-title":"Diabetologia"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib25","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.2337\/diacare.27.12.2898","article-title":"Gender difference in the impact of type 2 diabetes on coronary heart disease risk","volume":"27","author":"Juutilainen","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib26","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1464-5491.2009.02686.x","article-title":"Metabolic syndrome and short-term heart rate variability in young adults. The cardiovascular risk in young Finns study","volume":"26","author":"Koskinen","year":"2009","journal-title":"Diabet Med"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib27","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1161\/01.STR.0000166196.31227.91","article-title":"The metabolic syndrome is a stronger risk factor for early carotid atherosclerosis in women than in men","volume":"36","author":"Iglseder","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.atherosclerosis.2009.11.027","article-title":"The risk of the metabolic syndrome on carotid thickness and stiffness: sex and age specific effects","volume":"210","author":"Lin","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib29","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1210\/jcem-68-4-715","article-title":"The relative contributions of hepatic and peripheral tissues to insulin resistance in hyperandrogenic women","volume":"68","author":"Peiris","year":"1989","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib30","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1056\/NEJM199304153281501","article-title":"Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. The atherosclerosis risk in communities study investigators","volume":"328","author":"Nabulsi","year":"1993","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib31","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1210\/endo.135.6.7988435","article-title":"Follicle-stimulating hormone increases the expression of tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 and induces TIMP-1 AP-1 site binding complex(es) in prepubertal rat Sertoli cells","volume":"135","author":"Ulisse","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib32","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ijo.2009.286","article-title":"Gluteofemoral body fat as a determinant of metabolic health","volume":"34","author":"Manolopoulos","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib33","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1053\/euhj.1999.1756","article-title":"Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease","volume":"21","author":"Stefanadis","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib34","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1161\/01.STR.0000141702.26898.e9","article-title":"Carotid stiffness indicates risk of ischemic stroke and TIA in patients with internal carotid artery stenosis: the SMART study","volume":"35","author":"Dijk","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00004872-200201000-00012","article-title":"Reduced arterial distensibility is a predictor of cardiovascular disease in patients after renal transplantation","volume":"20","author":"Barenbrock","year":"2002","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.atherosclerosis.2011.08.007","article-title":"Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the cardiovascular risk in young Finns study and the health 2000 survey","volume":"220","author":"Koivistoinen","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0301-5629(98)00165-3","article-title":"Variability in ultrasonic measurements of arterial stiffness in the atherosclerosis risk in communities study","volume":"25","author":"Arnett","year":"1999","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0021-9150(00)00461-5","article-title":"Improved common carotid elasticity and intima-media thickness measurements from computer analysis of sequential ultrasound frames","volume":"154","author":"Selzer","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2012.04.004_bib39","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/(SICI)1097-0258(19981130)17:22<2597::AID-SIM940>3.0.CO;2-G","article-title":"The effects of measurement error in response variables and tests of association of explanatory variables in change models","volume":"17","author":"Yanez","year":"1998","journal-title":"Stat Med"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915012002559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915012002559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T03:25:17Z","timestamp":1588821917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915012002559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0021915012002559"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.04.004","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}