{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:10:35Z","timestamp":1777723835598,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 99-2320-B-037-015-MY3 and NSC 101-2320-B-041-003"],"award-info":[{"award-number":["NSC 99-2320-B-037-015-MY3 and NSC 101-2320-B-041-003"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chia-Nan University of Pharmacy and Science","award":["CN\u00a010029"],"award-info":[{"award-number":["CN\u00a010029"]}]}],"content-domain":{"domain":["atherosclerosis-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.atherosclerosis.2012.12.005","type":"journal-article","created":{"date-parts":[[2012,12,25]],"date-time":"2012-12-25T09:02:05Z","timestamp":1356426125000},"page":"364-372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Lercanidipine and labedipinedilol-A attenuate lipopolysaccharide\/interferon-\u03b3-induced inflammation in rat vascular smooth muscle cells through inhibition of HMGB1 release and MMP-2, 9 activities"],"prefix":"10.1016","volume":"226","author":[{"given":"Jwu-Lai","family":"Yeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Hau","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyh-Chong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ing-Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Fen","family":"Liou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib1","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/01.ATV.0000147534.69062.dc","article-title":"Potential role of endotoxin as a proinflammatory mediator of atherosclerosis","volume":"24","author":"Stoll","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1164\/rccm.200608-1103OC","article-title":"Selective NOD1 agonists cause shock and organ injury\/dysfunction in\u00a0vivo","volume":"175","author":"Cartwright","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib3","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1074\/jbc.M110.123968","article-title":"Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells","volume":"286","author":"Hsieh","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0065-2776(08)60742-7","article-title":"NF-\u03baB as a frequent target for immunosuppressive and anti-inflammatory molecules","volume":"65","author":"Baeuerle","year":"1997","journal-title":"Adv Immunol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib5","doi-asserted-by":"crossref","first-page":"693","DOI":"10.5551\/jat.12450","article-title":"Anti-atherosclerotic potential of dihydropyridine calcium channel blockers","volume":"19","author":"Ishii","year":"2012","journal-title":"J\u00a0Atheroscler Thromb"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00045391-200311000-00006","article-title":"Calcium antagonists and atherosclerosis protection in hypertension","volume":"10","author":"Hern\u00e1ndez","year":"2003","journal-title":"Am J Ther"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.atherosclerosis.2007.03.036","article-title":"Azelnidipine has anti-atherosclerotic effects independent of its blood pressure-lowering actions in monkeys and mice","volume":"196","author":"Nakano","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib8","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1586\/14779072.4.6.783","article-title":"Hypertension, possible vascular protection and lercanidipine","volume":"4","author":"Ram","year":"2006","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib9","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/01.HYP.0000063361.70525.3C","article-title":"Calcium antagonist treatment by lercanidipine prevents hyperpolarization in essential hypertension","volume":"41","author":"Taddei","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/01.fjc.0000154375.88283.5c","article-title":"The vasorelaxing action of labedipinedilol-A involves endothelial cell-derived NO and eNOS expression caused by calcium influx","volume":"45","author":"Liou","year":"2005","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.phrs.2008.09.015","article-title":"Lercanidipine inhibits vascular smooth muscle cell proliferation and neointimal formation via reducing intracellular reactive oxygen species and inactivating Ras-ERK1\/2 signaling","volume":"59","author":"Wu","year":"2009","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/00005344-200411000-00005","article-title":"Inhibition of mitogen-mediated proliferation of rat vascular smooth muscle cells by labedipinedilol-A through PKC and ERK 1\/2 pathway","volume":"44","author":"Liou","year":"2004","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.atherosclerosis.2011.04.022","article-title":"Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis","volume":"217","author":"Hsu","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.atherosclerosis.2012.04.013","article-title":"Biomarkers and location of atherosclerosis: matrix metalloproteinase-2 may be related to intracranial atherosclerosis","volume":"223","author":"Jeon","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.atherosclerosis.2011.03.042","article-title":"Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization","volume":"217","author":"Kaneko","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib16","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1161\/01.ATV.0000145573.36113.8a","article-title":"Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines","volume":"24","author":"Kalinina","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.carpath.2006.11.006","article-title":"HMGB1 expression by activated vascular smooth muscle cells in advanced human atherosclerosis plaques","volume":"16","author":"Inoue","year":"2007","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.192.4.565","article-title":"High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes","volume":"192","author":"Andersson","year":"2000","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib19","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1476-5381.2010.01126.x","article-title":"Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice","volume":"162","author":"Tsoyi","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib20","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1096\/fj.05-5514fje","article-title":"Activation of sPLA2-IIA and PGE2 production by high mobility group protein B1 in vascular smooth muscle cells sensitized by IL-1beta","volume":"20","author":"Jaulmes","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib21","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1189\/jlb.0404242","article-title":"Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms","volume":"76","author":"Chen","year":"2004","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib22","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.4049\/jimmunol.177.5.3337","article-title":"The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic\u2013polycytidylic acid or lipopolysaccharide","volume":"177","author":"Jiang","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/01.ATV.19.2.255","article-title":"Expression of tissue inhibitor of metalloproteinase-1, -2, and -3 during neointima formation in organ cultures of human saphenous vein","volume":"19","author":"Kranzh\u00f6fer","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/01.CIR.100.5.533","article-title":"Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-1 reduces atherosclerotic lesions in apolipoprotein E-deficient mice","volume":"100","author":"Rouis","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cardiores.2004.03.014","article-title":"NO suppresses while peroxynitrite sustains NF-kappaB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO","volume":"63","author":"Hattori","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.atherosclerosis.2005.08.035","article-title":"Overexpression of COX-2, prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB","volume":"187","author":"G\u00f3mez-Hern\u00e1ndez","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib27","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/emboj\/cdg139","article-title":"Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)","volume":"22","author":"Vermeulen","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib28","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.4049\/jimmunol.0903131","article-title":"Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis","volume":"184","author":"Penzo","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejphar.2003.09.034","article-title":"Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-kappa B activation","volume":"481","author":"Hattori","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib30","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/ATVBAHA.109.202309","article-title":"Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice","volume":"30","author":"Ishii","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bcp.2004.10.004","article-title":"Inhibition of interleukin-12 expression in diltiazem-treated dendritic cells through the reduction of nuclear factor-kappa B transcriptional activity","volume":"69","author":"Severa","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2012.12.005_bib32","first-page":"434","article-title":"Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness","volume":"52","author":"Cuschieri","year":"2002","journal-title":"J\u00a0Trauma"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915012008660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915012008660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T07:08:05Z","timestamp":1588835285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915012008660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0021915012008660"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.12.005","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lercanidipine and labedipinedilol-A attenuate lipopolysaccharide\/interferon-\u03b3-induced inflammation in rat vascular smooth muscle cells through inhibition of HMGB1 release and MMP-2, 9 activities","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}