{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:41:17Z","timestamp":1776789677507,"version":"3.51.2"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20249045"],"award-info":[{"award-number":["20249045"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21590952"],"award-info":[{"award-number":["21590952"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30960128"],"award-info":[{"award-number":["30960128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260068"],"award-info":[{"award-number":["81260068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.atherosclerosis.2013.01.004","type":"journal-article","created":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T04:38:54Z","timestamp":1358051934000},"page":"211-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Circulating cathepsin K as a potential novel biomarker of coronary artery disease"],"prefix":"10.1016","volume":"228","author":[{"given":"Xian Wu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiji","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryotaro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kuzuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib1","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1093\/emboj\/20.17.4629","article-title":"Lysosomal cysteine proteases: facts and opportunities","volume":"20","author":"Turk","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1161\/CIRCULATIONAHA.110.970038","article-title":"Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs","volume":"123","author":"Chatzizisis","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0002-9440(10)63114-8","article-title":"Increased expression of elastolytic cysteine proteases, cathepsins S and K, in the neointima of balloon-injured rat carotid arteries","volume":"164","author":"Cheng","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib4","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.111.066712","article-title":"Role for cysteine protease cathepsins in heart disease: focus on biology and mechanisms with clinical implication","volume":"125","author":"Cheng","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-5793(94)01349-6","article-title":"Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2","volume":"357","author":"Shi","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1172\/JCI181","article-title":"Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells","volume":"102","author":"Sukhova","year":"1998","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.atherosclerosis.2009.12.031","article-title":"AT1 blockade attenuates atherosclerotic plaque destabilization accompanied by the suppression of cathepsin S activity in apoE-deficient mice","volume":"210","author":"Sasaki","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib8","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1161\/HYPERTENSIONAHA.111.180935","article-title":"Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications","volume":"58","author":"Cheng","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2261-10-19","article-title":"Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes","volume":"10","author":"Barascuk","year":"2010","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib10","doi-asserted-by":"crossref","first-page":"H1479","DOI":"10.1152\/ajpheart.00954.2006","article-title":"Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis","volume":"292","author":"Platt","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/CIRCULATIONAHA.105.561449","article-title":"Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation","volume":"113","author":"Lutgens","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.atherosclerosis.2005.08.001","article-title":"Increased serum cathepsin S in patients with atherosclerosis and diabetes","volume":"186","author":"Liu","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/HYPERTENSIONAHA.111.187807","article-title":"Elastin degradation is associated with progressive aortic stiffening and all-cause mortality in predialysis chronic kidney disease","volume":"59","author":"Smith","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib14","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1093\/eurheartj\/ehs184","article-title":"Third universal definition of myocardial infarction","volume":"33","author":"Thygesen","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib15","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/S0735-1097(01)01175-5","volume":"37","author":"Mintz","year":"2001","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.atherosclerosis.2009.02.014","article-title":"Statin prevents plaque disruption in apoE-knockout mouse model through pleiotropic effect on acute inflammation","volume":"206","author":"Nakamura","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib17","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1056\/NEJMoa1110874","article-title":"Effect of two intensive statin regimens on progression of coronary disease","volume":"365","author":"Nicholls","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2353\/ajpath.2008.071126","article-title":"Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment","volume":"173","author":"Cheng","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/HJH.0b013e328341cedf","article-title":"Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin","volume":"29","author":"Cheng","year":"2011","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.atherosclerosis.2008.12.009","article-title":"Surrogate markers in clinical trials\u2013challenges and opportunities","volume":"206","author":"Duivenvoorden","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib21","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: current pathogenesis and therapeutic options","volume":"17","author":"Weber","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.atherosclerosis.2010.05.013","article-title":"Carotid plaque formation and serum biomarkers","volume":"213","author":"Hermus","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib23","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.atherosclerosis.2009.01.041","article-title":"Association of inflammatory markers with angiographic severity and extent of coronary artery disease","volume":"206","author":"Drakopoulou","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib24","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.atherosclerosis.2006.11.013","article-title":"C-reactive protein and angiographic characteristics of stable and unstable coronary artery disease: data from the prospective PREVEND cohort","volume":"196","author":"Geluk","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib25","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1161\/01.CIR.91.11.2844","article-title":"Molecular bases of the acute coronary syndromes","volume":"91","author":"Libby","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.amjcard.2005.08.020","article-title":"Comparison of levels of serum matrix metalloproteinase-9 in patients with acute myocardial infarction versus unstable angina pectoris versus stable angina pectoris","volume":"97","author":"Fukuda","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.atherosclerosis.2010.12.028","article-title":"Electronegative low-density lipoprotein: origin and impact on health and disease","volume":"215","author":"Mello","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib28","doi-asserted-by":"crossref","first-page":"34776","DOI":"10.1074\/jbc.M310814200","article-title":"Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in\u00a0vitro","volume":"279","author":"Oorni","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.atherosclerosis.2013.01.004_bib29","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.bbrc.2003.11.020","article-title":"Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells","volume":"312","author":"Lindstedt","year":"2003","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915013000373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915013000373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:22:15Z","timestamp":1762186935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915013000373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0021915013000373"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.01.004","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating cathepsin K as a potential novel biomarker of coronary artery disease","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}