{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T07:29:02Z","timestamp":1763105342139},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["atherosclerosis-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.atherosclerosis.2013.06.005","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T04:10:50Z","timestamp":1371787850000},"page":"430-439","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inhibition of monocyte chemotaxis by VB-201, a small molecule lecinoxoid, hinders atherosclerosis development in ApoE\u2212\/\u2212 mice"],"prefix":"10.1016","volume":"229","author":[{"given":"Erez","family":"Feige","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niva","family":"Yacov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaniv","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itzhak","family":"Levi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itzhak","family":"Mendel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oshrat","family":"Propheta-Meiran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Shoham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravit","family":"Hait-Darshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omri","family":"Polonsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror","family":"Harats","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Breitbart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/MOH.0b013e3283333949","article-title":"New observations on the trafficking and diapedesis of monocytes","volume":"17","author":"Kamei","year":"2010","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.1178331","article-title":"Development of monocytes, macrophages, and dendritic cells","volume":"327","author":"Geissmann","year":"2010","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1189\/jlb.1009671","article-title":"Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases","volume":"88","author":"Zhao","year":"2010","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib5","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1093\/brain\/awp144","article-title":"CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system","volume":"132","author":"Mildner","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nri1375","article-title":"Adhesion mechanisms regulating the migration of monocytes","volume":"4","author":"Imhof","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib7","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/ni.f.210","article-title":"Moving targets: cell migration inhibitors as new anti-inflammatory therapies","volume":"9","author":"Mackay","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1089\/ars.2009.2597","article-title":"Generation and biological activities of oxidized phospholipids","volume":"12","author":"Bochkov","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/978-1-4020-8830-8_12","article-title":"The role of phospholipid oxidation products in inflammatory and autoimmune diseases: evidence from animal models and in humans","volume":"49","author":"Leitinger","year":"2008","journal-title":"Subcell Biochem"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.freeradbiomed.2008.04.013","article-title":"Endothelial cell regulation by phospholipid oxidation products","volume":"45","author":"Berliner","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1160\/TH06-08-0474","article-title":"Inflammatory profile of oxidized phospholipids","volume":"97","author":"Bochkov","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/00041433-200208000-00003","article-title":"Oxidized lipids as mediators of coronary heart disease","volume":"13","author":"Navab","year":"2002","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib13","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/MOL.0b013e32833f2fcb","article-title":"Modified phospholipids as anti-inflammatory compounds","volume":"21","author":"Feige","year":"2010","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nature01023","article-title":"Protective role of phospholipid oxidation products in endotoxin-induced tissue damage","volume":"419","author":"Bochkov","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib15","doi-asserted-by":"crossref","first-page":"R27","DOI":"10.1186\/cc6805","article-title":"Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in\u00a0vivo","volume":"12","author":"Nonas","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib16","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1182\/blood-2008-11-191429","article-title":"Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids","volume":"114","author":"Bluml","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib17","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S1388-1981(02)00173-7","article-title":"Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate","volume":"1582","author":"Siess","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib18","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1073\/pnas.92.18.8264","article-title":"Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E","volume":"92","author":"Smith","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib19","first-page":"1687","article-title":"Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice","volume":"150","author":"Qiao","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib20","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1161\/ATVBAHA.110.221127","article-title":"Monocyte and macrophage dynamics during atherogenesis","volume":"31","author":"Ley","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jneuroim.2010.06.011","article-title":"A\u00a0lecinoxoid, an oxidized phospholipid small molecule, constrains CNS autoimmune disease","volume":"226","author":"Mendel","year":"2010","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib22","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1161\/01.ATV.0000081215.45714.71","article-title":"Oxidized phospholipid-induced endothelial cell\/monocyte interaction is mediated by a cAMP-dependent R-Ras\/PI3-kinase pathway","volume":"23","author":"Cole","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00041433-200310000-00002","article-title":"Oxidized phospholipids as modulators of inflammation in atherosclerosis","volume":"14","author":"Leitinger","year":"2003","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-1759(96)00224-4","article-title":"Glycation products in aged thioglycollate medium enhance the elicitation of peritoneal macrophages","volume":"201","author":"Li","year":"1997","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib25","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1172\/JCI57559","article-title":"ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice","volume":"121","author":"Murphy","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrd2734","article-title":"Chemokine receptor antagonists: overcoming developmental hurdles","volume":"8","author":"Horuk","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1517\/13543770802641353","article-title":"Chemokine receptor antagonists: part 2","volume":"19","author":"Pease","year":"2009","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib28","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1182\/blood-2002-11-3423","article-title":"Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor","volume":"102","author":"Selvaraj","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib29","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1046\/j.1365-2249.2002.01764.x","article-title":"Leucocyte chemotaxis: examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by monocyte chemoattractant proteins-1, -2, -3 and -4","volume":"127","author":"Wain","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejphar.2008.09.016","article-title":"Monocyte migration: a novel effect and signaling pathways of catestatin","volume":"598","author":"Egger","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib31","doi-asserted-by":"crossref","first-page":"14552","DOI":"10.1073\/pnas.0904073106","article-title":"Akt1 is critical for acute inflammation and histamine-mediated vascular leakage","volume":"106","author":"Di Lorenzo","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.atherosclerosis.2013.06.005_bib32","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.287.5455.1049","article-title":"Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation","volume":"287","author":"Hirsch","year":"2000","journal-title":"Science"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915013003699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915013003699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:29:21Z","timestamp":1563236961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915013003699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0021915013003699"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.06.005","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of monocyte chemotaxis by VB-201, a small molecule lecinoxoid, hinders atherosclerosis development in ApoE\u2212\/\u2212 mice","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}