{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:15:22Z","timestamp":1792818922950,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["atherosclerosis-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.atherosclerosis.2013.06.021","type":"journal-article","created":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T15:31:23Z","timestamp":1374334283000},"page":"242-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Elevated serum bilirubin levels are inversely associated with coronary artery atherosclerosis"],"prefix":"10.1016","volume":"230","author":[{"given":"Seung Joo","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Eun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goh Eun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Yeon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whal","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Heon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis: a perspective for the 1990s","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/01.ATV.0000150649.39934.13","article-title":"Oxidative stress and vascular disease","volume":"25","author":"Madamanchi","year":"2005","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib3","doi-asserted-by":"crossref","first-page":"H2298","DOI":"10.1152\/ajpheart.00508.2003","article-title":"Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells","volume":"285","author":"Ceaser","year":"2003","journal-title":"American Journal of Physiology, Heart and Circulatory Physiology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib4","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/0140-6736(93)90206-V","article-title":"Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine","volume":"341","author":"Frankel","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib5","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1161\/01.ATV.16.2.250","article-title":"Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease","volume":"16","author":"Hopkins","year":"1996","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.atherosclerosis.2005.05.011","article-title":"Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women","volume":"184","author":"Erdogan","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/ATVBAHA.107.153262","article-title":"Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004","volume":"28","author":"Perlstein","year":"2008","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib9","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1161\/CIRCULATIONAHA.106.633206","article-title":"Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study","volume":"114","author":"Lin","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib10","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/dc07-2126","article-title":"Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients","volume":"31","author":"Chen","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.atherosclerosis.2009.02.010","article-title":"Low serum bilirubin concentration is associated with coronary artery calcification (CAC)","volume":"206","author":"Tanaka","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/clc.21964","article-title":"Inverse relation of total serum bilirubin to coronary artery calcification score detected by multidetector computed tomography in males","volume":"35","author":"Zhang","year":"2012","journal-title":"Clinical Cardiology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1148\/radiol.11101725","article-title":"Effect of metabolic syndrome on coronary artery stenosis and plaque characteristics as assessed with 64-detector row cardiac CT","volume":"261","author":"Lim","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib14","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"20","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s10554-011-9922-2","article-title":"The prevalence and distribution of coronary artery calcium in asymptomatic Korean population","volume":"28","author":"Park","year":"2012","journal-title":"The International Journal of Cardiovascular Imaging"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jacc.2006.02.064","article-title":"Prevalence of noncalcified coronary plaques by 64-slice computed tomography in patients with an intermediate risk for significant coronary artery disease","volume":"48","author":"Hausleiter","year":"2006","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2013.06.021_bib17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jacc.2005.03.071","article-title":"Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography","volume":"46","author":"Leber","year":"2005","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib18","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.STR.32.2.580-b","article-title":"High serum bilirubin level is inversely associated with the presence of carotid plaque","volume":"32","author":"Ishizaka","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib19","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/archinte.168.12.1333","article-title":"Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"168","author":"Folsom","year":"2008","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib20","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1161\/CIRCULATIONAHA.106.178458","volume":"114","author":"Budoff","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1148\/radiol.2352031813","article-title":"Coronary artery stenoses: detection with calcium scoring, CT angiography, and both methods combined","volume":"235","author":"Lau","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib22","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/S0735-1097(01)01115-9","article-title":"Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography","volume":"37","author":"Schroeder","year":"2001","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/CIRCIMAGING.109.880625","article-title":"Incremental prognostic value of coronary CT angiography in patients with suspected coronary artery disease","volume":"3","author":"Russo","year":"2010","journal-title":"Circulation Cardiovascular imaging"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9150(93)90217-I","article-title":"Modified forms of low density lipoprotein and atherosclerosis","volume":"98","author":"Aviram","year":"1993","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib25","doi-asserted-by":"crossref","first-page":"16712","DOI":"10.1016\/S0021-9258(19)89449-8","article-title":"Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation","volume":"269","author":"Neuzil","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0008-6363(98)00278-8","article-title":"Heme oxygenase-carbon monoxide signaling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?","volume":"41","author":"Siow","year":"1999","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib27","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.amjcard.2010.08.034","article-title":"Mortality incidence of patients with non-obstructive coronary artery disease diagnosed by computed tomography angiography","volume":"107","author":"Ahmadi","year":"2011","journal-title":"The American Journal of Cardiology"},{"key":"10.1016\/j.atherosclerosis.2013.06.021_bib29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1148\/radiol.2442061218","article-title":"Diagnostic performance of multidetector CT angiography for assessment of coronary artery disease: meta-analysis","volume":"244","author":"Vanhoenacker","year":"2007","journal-title":"Radiology"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915013003870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915013003870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T21:12:21Z","timestamp":1646169141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915013003870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0021915013003870"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.06.021","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated serum bilirubin levels are inversely associated with coronary artery atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}