{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:06:28Z","timestamp":1767971188031,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institute of Health","award":["R01 HL098435"],"award-info":[{"award-number":["R01 HL098435"]}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Louisiana Board of Regents Superior Toxicology Fellowship","award":["LEQSF (2008-13)-FG-20"],"award-info":[{"award-number":["LEQSF (2008-13)-FG-20"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","atherosclerosis-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.atherosclerosis.2013.11.052","type":"journal-article","created":{"date-parts":[[2013,12,8]],"date-time":"2013-12-08T10:45:10Z","timestamp":1386499510000},"page":"277-284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Flow patterns regulate hyperglycemia-induced subendothelial matrix remodeling during early atherogenesis"],"prefix":"10.1016","volume":"232","author":[{"given":"Jonette","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Arif","family":"Yurdagul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall C.","family":"McInnis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Wayne","family":"Orr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib1","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1001\/jama.292.20.2495","article-title":"Trends in cardiovascular complications of diabetes","volume":"292","author":"Fox","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib2","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.jacc.2009.09.009","article-title":"Inflammation in atherosclerosis: from pathophysiology to practice","volume":"54","author":"Libby","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib3","article-title":"Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes","volume":"2012","author":"Funk","year":"2012","journal-title":"Int J Vasc Med"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1172\/JCI200417867","article-title":"Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions","volume":"114","author":"Renard","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib6","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1161\/01.CIR.103.11.1546","article-title":"Effects of nonlipid risk factors on atherosclerosis in youth with a favorable lipoprotein profile","volume":"103","author":"McGill","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib7","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2337\/diabetes.51.2.493","article-title":"Carotid artery intima-media thickness in children with type 1 diabetes","volume":"51","author":"Jarvisalo","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib8","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1056\/NEJMoa0802743","article-title":"Effects of intensive glucose lowering in type 2 diabetes","volume":"358","author":"Gerstein","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib9","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","article-title":"Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes","volume":"358","author":"Patel","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib10","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","article-title":"10-year follow-up of intensive glucose control in type 2 diabetes","volume":"359","author":"Holman","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib11","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1056\/NEJMoa052187","article-title":"Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes","volume":"353","author":"Nathan","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nrm2596","article-title":"Mechanotransduction in vascular physiology and atherogenesis","volume":"10","author":"Hahn","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1083\/jcb.200410073","article-title":"The subendothelial extracellular matrix modulates NF-kappaB activation by flow: a potential role in atherosclerosis","volume":"169","author":"Orr","year":"2005","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib14","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1161\/CIRCRESAHA.109.210286","article-title":"Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells","volume":"106","author":"Funk","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1083\/jcb.200609008","article-title":"Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis","volume":"176","author":"Orr","year":"2007","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib16","article-title":"Altered nitric oxide production mediates matrix-specific PAK2 and NF-kappaB activation by flow","author":"Yurdagul","year":"2012","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib17","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1161\/ATVBAHA.108.181081","article-title":"Fibronectin is an important regulator of flow-induced vascular remodeling","volume":"29","author":"Chiang","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib18","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/emmm.201200237","article-title":"Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation","volume":"4","author":"Rohwedder","year":"2012","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000096722","article-title":"Arterial stiffness and extracellular matrix","volume":"44","author":"Diez","year":"2007","journal-title":"Adv Cardiol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1017\/S1431927611012256","article-title":"Diabetes-induced alterations in the extracellular matrix and their impact on myocardial function","volume":"18","author":"Law","year":"2012","journal-title":"Microsc Microanal"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib21","first-page":"3166","article-title":"A\u00a0long-term siRNA strategy regulates fibronectin overexpression and improves vascular lesions in retinas of diabetic rats","volume":"17","author":"Roy","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib22","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2337\/diabetes.52.5.1229","article-title":"Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats","volume":"52","author":"Roy","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib23","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1369\/0022155412465073","article-title":"Diabetic nephropathy and extracellular matrix","volume":"60","author":"Kolset","year":"2012","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib24","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/ATVBAHA.111.242792","article-title":"EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis","volume":"32","author":"Funk","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1161\/CIRCRESAHA.108.182097","article-title":"p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow","volume":"103","author":"Orr","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib26","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1091\/mbc.E06-04-0289","article-title":"Matrix-specific suppression of integrin activation in shear stress signaling","volume":"17","author":"Orr","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib27","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1152\/physrev.00014.2004","article-title":"Expression and function of laminins in the embryonic and mature vasculature","volume":"85","author":"Hallmann","year":"2005","journal-title":"Physiol Rev"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib28","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1161\/ATVBAHA.110.219147","article-title":"A\u00a0selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice","volume":"31","author":"Johnson","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib29","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/2012","article-title":"Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts","volume":"4","author":"Park","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib30","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3109\/02713683.2010.514659","article-title":"Vascular basement membrane thickening in diabetic retinopathy","volume":"35","author":"Roy","year":"2010","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib31","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1167\/iovs.08-2377","article-title":"Tight glycemic control regulates fibronectin expression and basement membrane thickening in retinal and glomerular capillaries of diabetic rats","volume":"50","author":"Cherian","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib32","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2003-09-3363","article-title":"Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis","author":"Tan","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib33","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1073\/pnas.87.1.404","article-title":"Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory","volume":"87","author":"Roy","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib34","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00125-007-0684-2","article-title":"Reactive oxygen species mediate a cellular 'memory' of high glucose stress signalling","volume":"50","author":"Ihnat","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib35","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0002-9149(80)90500-7","article-title":"Absence of correlation between coronary arterial atherosclerosis and severity or duration of diabetes mellitus of adult onset","volume":"46","author":"Vigorita","year":"1980","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib36","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/CIRCRESAHA.107.156877","article-title":"Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells","volume":"102","author":"Woo","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/10623320601177213","article-title":"Elevated glucose attenuates agonist- and flow-stimulated endothelial nitric oxide synthase activity in microvascular retinal endothelial cells","volume":"14","author":"Connell","year":"2007","journal-title":"Endothelium"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib38","doi-asserted-by":"crossref","first-page":"11870","DOI":"10.1073\/pnas.0502488102","article-title":"Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction","volume":"102","author":"Musicki","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib39","doi-asserted-by":"crossref","first-page":"E145","DOI":"10.1152\/ajpendo.00034.2011","article-title":"Spontaneously diabetic Ins2(+\/Akita):apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis","volume":"301","author":"Jun","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib40","doi-asserted-by":"crossref","first-page":"H2498","DOI":"10.1152\/ajpheart.00869.2011","article-title":"Shear stress modulates RAGE-mediated inflammation in a model of diabetes-induced metabolic stress","volume":"302","author":"DeVerse","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.atherosclerosis.2003.08.023","article-title":"High glucose induced NF-kappaB DNA-binding activity in HAEC is maintained under low shear stress but inhibited under high shear stress: role of nitric oxide","volume":"171","author":"Mohan","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib42","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1161\/CIRCRESAHA.109.216283","article-title":"Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation","volume":"106","author":"Feaver","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.atherosclerosis.2013.11.052_bib43","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1161\/ATVBAHA.111.227827","article-title":"Hemodynamic activation of beta-catenin and T-cell-specific transcription factor signaling in vascular endothelium regulates fibronectin expression","volume":"31","author":"Gelfand","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915013007107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915013007107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T05:22:20Z","timestamp":1538976140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915013007107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0021915013007107"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.11.052","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flow patterns regulate hyperglycemia-induced subendothelial matrix remodeling during early atherogenesis","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.11.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}