{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:13:30Z","timestamp":1785039210803,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","atherosclerosis-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.atherosclerosis.2016.01.017","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T04:17:49Z","timestamp":1452658669000},"page":"367-373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Coronary artery Calcium predicts Cardiovascular events in participants with a low lifetime risk of Cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)"],"prefix":"10.1016","volume":"246","author":[{"given":"Parag H.","family":"Joshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7673-6143","authenticated-orcid":false,"given":"Birju","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Blaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarett D.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Blankstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-1946","authenticated-orcid":false,"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Agatston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"Blumenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurram","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib1","doi-asserted-by":"crossref","DOI":"10.1161\/01.cir.0000442015.53336.12","article-title":"Heart disease and stroke statistics\u20132014 update: a report from the american heart association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham heart study","volume":"117","author":"D'Agostino","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib3","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1161\/01.cir.0000437741.48606.98","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the american college of cardiology\/American heart association task force on practice guidelines","volume":"129","author":"Goff","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib4","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1161\/CIRCULATIONAHA.109.849166","article-title":"Cardiovascular risk prediction: basic concepts, current status, and future directions","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1056\/NEJMoa1012848","article-title":"Lifetime risks of cardiovascular disease","volume":"366","author":"Berry","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib6","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1161\/CIRCIMAGING.111.964528","article-title":"Interplay of coronary artery calcification and traditional risk factors for the prediction of all-cause mortality in asymptomatic individuals","volume":"5","author":"Nasir","year":"2012","journal-title":"Circ. Cardiovasc. Imag."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jacc.2011.01.055","article-title":"Predictors of coronary heart disease events among asymptomatic persons with low low-density lipoprotein cholesterol MESA (Multi-Ethnic study of Atherosclerosis)","volume":"58","author":"Blankstein","year":"2011","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib8","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1093\/eurheartj\/eht508","article-title":"Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the multi-ethnic study of Atherosclerosis","volume":"35","author":"Silverman","year":"2014","journal-title":"Eur. Heart. J."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib9","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-ethnic study of atherosclerosis: objectives and design","volume":"156","author":"Bild","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1148\/radiol.2341040439","article-title":"Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of multi-ethnic study of atherosclerosis (MESA) and coronary artery risk development in young adults (CARDIA) study","volume":"234","author":"Carr","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib11","first-page":"827","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"JAmCollCardiol"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib12","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jacc.2010.06.030","article-title":"Coronary risk stratification, discrimination, and reclassification improvement based on quantification of subclinical coronary atherosclerosis: the heinz nixdorf recall study","volume":"56","author":"Erbel","year":"2010","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1001\/jama.291.2.210","article-title":"Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals","volume":"291","author":"Greenland","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib14","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1001\/jama.2010.461","article-title":"Coronary artery calcium score and risk classification for coronary heart disease prediction","volume":"303","author":"Polonsky","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib15","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1148\/radiol.2283021006","article-title":"Prognostic value of cardiac risk factors and coronary artery calcium screening for all-cause mortality","volume":"228","author":"Shaw","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib16","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1007\/s12350-012-9626-6","article-title":"What is the role of calcium scoring in the age of coronary computed tomographic angiography?","volume":"19","author":"Joshi","year":"2012","journal-title":"J.\u00a0Nucl. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jacc.2005.02.089","article-title":"Treatment of asymptomatic adults with elevated coronary calcium scores with atorvastatin, vitamin C, and vitamin E: the St. Francis heart study randomized clinical trial","volume":"46","author":"Arad","year":"2005","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib18","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","article-title":"Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials","volume":"376","author":"Baigent","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/CIRCOUTCOMES.110.958496","article-title":"Understanding the utility of zero coronary calcium as a prognostic test: a Bayesian approach","volume":"4","author":"Blaha","year":"2011","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib20","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.jacc.2015.07.066","article-title":"Implications of coronary artery calcium testing among statin candidates according to american college of cardiology\/American heart association cholesterol management guidelines: MESA (Multi-Ethnic study of atherosclerosis)","volume":"66","author":"Nasir","year":"2015","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pcad.2015.05.006","article-title":"Discordance between risk factors and coronary artery calcium: implications for guiding treatment strategies in primary prevention settings","volume":"58","author":"Joshi","year":"2015","journal-title":"Prog. Cardiovasc Dis."},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib22","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2012.9624","article-title":"Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals","volume":"308","author":"Yeboah","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.atherosclerosis.2016.01.017_bib23","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.jacc.2011.01.019","article-title":"Impact of coronary artery calcium scanning on coronary risk factors and downstream testing the EISNER (Early identification of subclinical atherosclerosis by noninvasive imaging Research) prospective randomized trial","volume":"57","author":"Rozanski","year":"2011","journal-title":"J.\u00a0Am. Coll. Cardiol."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002191501630017X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002191501630017X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T02:52:12Z","timestamp":1537066332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002191501630017X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":23,"alternative-id":["S002191501630017X"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2016.01.017","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coronary artery Calcium predicts Cardiovascular events in participants with a low lifetime risk of Cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2016.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}