{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:42Z","timestamp":1777370922096,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand (NRCT)","doi-asserted-by":"publisher","award":["101413"],"award-info":[{"award-number":["101413"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand (NRCT)","doi-asserted-by":"publisher","award":["115870"],"award-info":[{"award-number":["115870"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand (NRCT)","doi-asserted-by":"publisher","award":["139514"],"award-info":[{"award-number":["139514"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Office of The Higher Education Commission, Ministry of Education"},{"name":"Postgraduate Program in Biomedical Sciences, Graduate School"},{"name":"Cardiovascular Research Group (CVRG), Khon Kaen University, Thailand"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","atherosclerosis-journal.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.atherosclerosis.2016.03.005","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T20:14:02Z","timestamp":1457208842000},"page":"140-148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Association of combined genetic variations in PPAR\u03b3, PGC-1\u03b1, and LXR\u03b1 with coronary artery disease and severity in Thai population"],"prefix":"10.1016","volume":"248","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-8341","authenticated-orcid":false,"given":"Pratthana","family":"Yongsakulchai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatri","family":"Settasatian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nongnuch","family":"Settasatian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nantarat","family":"Komanasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Upa","family":"Kukongwiriyapan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele L.","family":"Cote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pongsak","family":"Intharapetch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vichai","family":"Senthong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib1","series-title":"Global Health Estimates: Deaths by Cause, Age, Sex and Country, 2000-2012","author":"World Health Organization","year":"2014"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib2","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1161\/CIRCULATIONAHA.108.790048","article-title":"Cardiovascular disease and risk factors in Asia: a selected review","volume":"118","author":"Ueshima","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib3","series-title":"World Heart Day 2015. Bureau of Non-communicable Disease","author":"Nitaya","year":"2015"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib5","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0006-2952(00)00430-5","article-title":"Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis","volume":"60","author":"Neve","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1056-8727(01)00203-3","article-title":"Roles of peroxisome proliferator-activated receptor gamma in cardiovascular disease","volume":"16","author":"Takano","year":"2002","journal-title":"J.\u00a0Diabetes Complicat."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.gde.2008.07.016","article-title":"Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors","volume":"18","author":"Hong","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1110\/ps.04951405","article-title":"Ligand-binding regulation of LXR\/RXR and LXR\/PPAR heterodimerizations: SPR technology-based kinetic analysis correlated with molecular dynamics simulation","volume":"14","author":"Yue","year":"2005","journal-title":"Protein Sci. Publ. Protein Soc."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib9","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1128\/MCB.24.8.3430-3444.2004","article-title":"Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression","volume":"24","author":"Seo","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","article-title":"A\u00a0cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis","volume":"92","author":"Puigserver","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1042\/bj20021665","article-title":"Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha","volume":"371","author":"Oberkofler","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-2275(20)30159-0","article-title":"PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism","volume":"43","author":"Walczak","year":"2002","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tem.2004.03.003","article-title":"PPARs and LXRs: atherosclerosis goes nuclear","volume":"15","author":"Barish","year":"2004","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.bbalip.2006.04.012","article-title":"Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1","volume":"1761","author":"Cavelier","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib15","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1194\/jlr.R400010-JLR200","article-title":"PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis","volume":"45","author":"Li","year":"2004","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/83348","article-title":"PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway","volume":"7","author":"Chinetti","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/hmg\/7.3.435","article-title":"A\u00a0genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans","volume":"7","author":"Meirhaeghe","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib18","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1194\/jlr.M300363-JLR200","article-title":"Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian population","volume":"45","author":"Tai","year":"2004","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0008-6363(99)00256-4","article-title":"Peroxisome proliferator-activated receptor gamma C161-->T polymorphism and coronary artery disease","volume":"44","author":"Wang","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib20","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1007\/s11033-011-0931-y","article-title":"Association between C1431T polymorphism in peroxisome proliferator-activated receptor-gamma gene and coronary artery disease in Chinese Han population","volume":"39","author":"Zhou","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib21","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2337\/diabetes.52.3.895","article-title":"A\u00a0Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians","volume":"52","author":"Muller","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/dmrr.1158","article-title":"Association of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene polymorphisms and type 2 diabetes mellitus: a meta-analysis","volume":"27","author":"Yang","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib23","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1440-1681.2008.04988.x","article-title":"Association between PPARGC1A gene polymorphisms and coronary artery disease in a Chinese population","volume":"35","author":"Zhang","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.atherosclerosis.2011.01.031","article-title":"Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study","volume":"216","author":"Legry","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1476-511X-13-34","article-title":"Association of liver X receptor alpha (LXRalpha) gene polymorphism and coronary heart disease, serum lipids and glucose levels","volume":"13","author":"Zhou","year":"2014","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/FPC.0b013e3283452fec","article-title":"Liver X receptor alpha gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study","volume":"21","author":"Price","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib27","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1161\/ATVBAHA.111.223867","article-title":"Genetic variation in liver X receptor alpha and risk of ischemic vascular disease in the general population","volume":"31","author":"Stender","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib28","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0002-9149(83)80105-2","article-title":"A\u00a0more meaningful scoring system for determining the severity of coronary heart disease","volume":"51","author":"Gensini","year":"1983","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2012.07.007","article-title":"Coronary angiographic scoring systems: an evaluation of their equivalence and validity","volume":"164","author":"Neeland","year":"2012","journal-title":"Am. Heart J."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib30","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib31","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/00004872-200311000-00002","article-title":"World Health Organization (WHO)\/International Society of Hypertension (ISH) statement on management of hypertension","volume":"21","author":"Whitworth","year":"2003","journal-title":"J.\u00a0Hypertens."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib32","doi-asserted-by":"crossref","first-page":"543746","DOI":"10.1155\/2009\/543746","article-title":"Peroxisome proliferator-activated receptor gamma polymorphisms and coronary heart disease","volume":"2009","author":"Dallongeville","year":"2009","journal-title":"PPAR Res."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11010-011-0987-y","article-title":"Effects of the PPARG P12A and C161T gene variants on serum lipids in coronary heart disease patients with and without Type 2 diabetes","volume":"358","author":"Yilmaz-Aydogan","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib34","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.4238\/2011.December.12.2","article-title":"Association between peroxisome proliferator-activated receptor gamma coactivator-1 alpha polymorphism and hypertension in Mongolians in Inner Mongolia","volume":"10","author":"Su","year":"2011","journal-title":"Genet. Mol. Res. GMR"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib35","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1152\/japplphysiol.90423.2008","article-title":"The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals","volume":"105","author":"Vimaleswaran","year":"2008","journal-title":"J.\u00a0Appl. Physiol. (1985)"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2261-7-33","article-title":"The impact of severity of hypertension on association of PGC-1alpha gene with blood pressure and risk of hypertension","volume":"7","author":"Xie","year":"2007","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2350-12-10","article-title":"Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans","volume":"12","author":"Myles","year":"2011","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib38","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.metabol.2009.08.021","article-title":"Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity","volume":"59","author":"Weng","year":"2010","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib39","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s00125-005-0129-8","article-title":"Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men","volume":"49","author":"Ridderstrale","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib40","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ymgme.2005.07.002","article-title":"Effects of the peroxisome proliferator-activated receptor-gamma co-activator-1 Gly482Ser variant on features of the metabolic syndrome","volume":"86","author":"Vohl","year":"2005","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib41","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1161\/01.STR.0000238584.57864.d4","article-title":"Associations of PPARGC1A haplotypes with plaque score but not with intima-media thickness of carotid arteries in middle-aged subjects","volume":"37","author":"Iglseder","year":"2006","journal-title":"Stroke J. Cereb. Circ."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib42","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bbrc.2006.12.042","article-title":"Analysis of PGC-1alpha variants Gly482Ser and Thr612Met concerning their PPARgamma2-coactivation function","volume":"353","author":"Nitz","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib43","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/eurheartj\/eht467","article-title":"The gut microbiome as novel cardio-metabolic target: the time has come!","volume":"35","author":"Vinje","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib44","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/rej.2013.1447","article-title":"Dietary modification of the microbiome affects risk for cardiovascular disease","volume":"16","author":"Mendelsohn","year":"2013","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib45","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1016\/j.ijcard.2013.07.232","article-title":"Contrasting circulating microbiome in cardiovascular disease patients and healthy individuals","volume":"168","author":"Rajendhran","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib46","first-page":"711","article-title":"Antiplatelet therapy in populations at high risk of atherothrombosis","volume":"98","author":"Faxon","year":"2006","journal-title":"J.\u00a0Natl. Med. Assoc."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/10408360600793082","article-title":"Present and future biochemical markers for detection of acute coronary syndrome","volume":"43","author":"Eriksson","year":"2006","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib48","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1097-2765(01)00164-2","article-title":"A\u00a0PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis","volume":"7","author":"Chawla","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.atherosclerosis.2016.03.005_bib49","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0092-8674(00)81575-5","article-title":"PPARgamma promotes monocyte\/macrophage differentiation and uptake of oxidized LDL","volume":"93","author":"Tontonoz","year":"1998","journal-title":"Cell"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915016300806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915016300806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T10:48:28Z","timestamp":1655981308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915016300806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":49,"alternative-id":["S0021915016300806"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2016.03.005","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of combined genetic variations in PPAR\u03b3, PGC-1\u03b1, and LXR\u03b1 with coronary artery disease and severity in Thai population","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2016.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}