{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T17:39:16Z","timestamp":1770572356051,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2011\/14201-2"],"award-info":[{"award-number":["2011\/14201-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","atherosclerosis-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.atherosclerosis.2016.09.010","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T04:11:51Z","timestamp":1473999111000},"page":"73-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Epicardial fat is associated with severity of subclinical coronary atherosclerosis in familial hypercholesterolemia"],"prefix":"10.1016","volume":"254","author":[{"given":"Leonardo C.","family":"Mangili","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otavio C.","family":"Mangili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-1754","authenticated-orcid":false,"given":"M\u00e1rcio S.","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio H.","family":"Miname","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-7361","authenticated-orcid":false,"given":"Paulo H.","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo M.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Rochitte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-6582","authenticated-orcid":false,"given":"Raul D.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2016.09.010_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-8587(16)30041-9","article-title":"Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel","author":"Santos","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"11","key":"10.1016\/j.atherosclerosis.2016.09.010_bib2","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1210\/jc.2012-1563","article-title":"Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication","volume":"97","author":"Benn","year":"2012","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2016.09.010_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.atherosclerosis.2010.10.001","article-title":"Evaluation of subclinical atherosclerosis by computed tomography coronary angiography and its association with risk factors in familial hypercholesterolemia","volume":"213","author":"Miname","year":"2010","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2016.09.010_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.atherosclerosis.2003.11.010","article-title":"International Panel on Management of Familial H. Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia","volume":"173","author":"Civeira","year":"2004","journal-title":"Atherosclerosis"},{"issue":"24","key":"10.1016\/j.atherosclerosis.2016.09.010_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.111.077602","article-title":"Ectopic fat depots and cardiovascular disease","volume":"124","author":"Britton","year":"2011","journal-title":"Circulation"},{"issue":"23","key":"10.1016\/j.atherosclerosis.2016.09.010_bib6","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1161\/01.CIR.98.23.2580","article-title":"Usefulness of electron beam tomography in adolescents and young adults with heterozygous familial hypercholesterolemia","volume":"98","author":"Gidding","year":"1998","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2016.09.010_bib7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.atherosclerosis.2013.12.020","article-title":"Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers","volume":"233","author":"Besseling","year":"2014","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2016.09.010_bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3945\/ajcn.2008.27358","article-title":"The association of pericardial fat with incident coronary heart disease: the multi-ethnic study of Atherosclerosis (MESA)","volume":"90","author":"Ding","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.atherosclerosis.2016.09.010_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCULATIONAHA.107.743062","article-title":"Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study","volume":"117","author":"Rosito","year":"2008","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.atherosclerosis.2016.09.010_bib10","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jcmg.2014.07.002","article-title":"Association of epicardial adipose tissue with progression of coronary artery calcification is more pronounced in the early phase of atherosclerosis: results from the Heinz Nixdorf recall study","volume":"7","author":"Mahabadi","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2016.09.010_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0002-9149(93)90155-6","article-title":"Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics","volume":"72","author":"Williams","year":"1993","journal-title":"Am. J. Cardiol."},{"issue":"4","key":"10.1016\/j.atherosclerosis.2016.09.010_bib12","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2016.09.010_bib13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.atherosclerosis.2009.10.023","article-title":"Relation between visceral fat and coronary artery disease evaluated by multidetector computed tomography","volume":"209","author":"Marques","year":"2010","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2016.09.010_bib14","doi-asserted-by":"crossref","first-page":"748","DOI":"10.2214\/AJR.07.2763","article-title":"Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound","volume":"190","author":"Sun","year":"2008","journal-title":"AJR Am. J. Roentgenol."},{"issue":"4","key":"10.1016\/j.atherosclerosis.2016.09.010_bib15","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00330-008-1203-7","article-title":"Coronary CT angiography using 64 detector rows: methods and design of the multi-centre trial CORE-64","volume":"19","author":"Miller","year":"2009","journal-title":"Eur. Radiol."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2016.09.010_bib16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jcct.2009.01.001","article-title":"SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography","volume":"3","author":"Raff","year":"2009","journal-title":"J.\u00a0Cardiovasc Comput. Tomogr."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2016.09.010_bib17","doi-asserted-by":"crossref","first-page":"e114358","DOI":"10.1371\/journal.pone.0114358","article-title":"Pericardial fat is associated with coronary artery calcification in non-dialysis dependent chronic kidney disease patients","volume":"9","author":"Harada","year":"2014","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.atherosclerosis.2016.09.010_bib18","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/j.jacc.2012.12.051","article-title":"Effect of intensive versus moderate lipid-lowering therapy on epicardial adipose tissue in hyperlipidemic post-menopausal women: a substudy of the BELLES trial (Beyond Endorsed Lipid Lowering with EBT Scanning)","volume":"61","author":"Alexopoulos","year":"2013","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"13","key":"10.1016\/j.atherosclerosis.2016.09.010_bib19","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.jacc.2015.01.036","article-title":"Impact of statins on serial coronary calcification during atheroma progression and regression","volume":"65","author":"Puri","year":"2015","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2016.09.010_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.atherosclerosis.2007.12.014","article-title":"No correlation and low agreement of imaging and inflammatory atherosclerosis' markers in familial hypercholesterolemia","volume":"200","author":"Martinez","year":"2008","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2016.09.010_bib21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.atherosclerosis.2011.09.052","article-title":"Accelerated subclinical coronary atherosclerosis in patients with familial hypercholesterolemia","volume":"219","author":"Neefjes","year":"2011","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2016.09.010_bib22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/heart.90.1.92","article-title":"Detection of subclinical atherosclerosis by electron beam tomography in females with heterozygous familial hypercholesterolaemia","volume":"90","author":"Santos","year":"2004","journal-title":"Heart"},{"issue":"19","key":"10.1016\/j.atherosclerosis.2016.09.010_bib23","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.jacc.2014.01.063","article-title":"Lipoprotein(a) levels in familial hypercholesterolemia: an important predictor of cardiovascular disease independent of the type of LDL receptor mutation","volume":"63","author":"Alonso","year":"2014","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.atherosclerosis.2016.09.010_bib24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/ehjci\/jes179","article-title":"Body mass index and the prevalence, severity, and risk of coronary artery disease: an international multicentre study of 13,874 patients","volume":"14","author":"Labounty","year":"2013","journal-title":"Eur. Heart J. Cardiovasc Imaging"},{"issue":"20","key":"10.1016\/j.atherosclerosis.2016.09.010_bib25","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1161\/01.CIR.0000099542.57313.C5","article-title":"Human epicardial adipose tissue is a source of inflammatory mediators","volume":"108","author":"Mazurek","year":"2003","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2016.09.010_bib26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/CIRCIMAGING.113.001047","article-title":"Prognostic value of nonobstructive and obstructive coronary artery disease detected by coronary computed tomography angiography to identify cardiovascular events","volume":"7","author":"Bittencourt","year":"2014","journal-title":"Circ. Cardiovasc. imaging"},{"issue":"10","key":"10.1016\/j.atherosclerosis.2016.09.010_bib27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jacc.2010.10.011","article-title":"Prognostic value of cardiac computed tomography angiography: a systematic review and meta-analysis","volume":"57","author":"Hulten","year":"2011","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2016.09.010_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.atherosclerosis.2016.01.040","article-title":"Validation of coronary computed tomography angiography scores for non-invasive assessment of atherosclerotic burden through a comparison with multivessel intravascular ultrasound","volume":"247","author":"Cavalcante","year":"2016","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.atherosclerosis.2016.09.010_bib29","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jcmg.2009.12.013","article-title":"Pericardial fat burden on ECG-gated noncontrast CT in asymptomatic patients who subsequently experience adverse cardiovascular events","volume":"3","author":"Cheng","year":"2010","journal-title":"JACC Cardiovasc. imaging"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2016.09.010_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/CIRCULATIONAHA.106.675355","article-title":"Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study","volume":"116","author":"Fox","year":"2007","journal-title":"Circulation"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915016313247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915016313247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T07:28:38Z","timestamp":1536391718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915016313247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":30,"alternative-id":["S0021915016313247"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2016.09.010","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epicardial fat is associated with severity of subclinical coronary atherosclerosis in familial hypercholesterolemia","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2016.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}