{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:06:17Z","timestamp":1789754777887,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ho Hospital, Taipei Medical University","award":["104TMU-SHH-23"],"award-info":[{"award-number":["104TMU-SHH-23"]}]},{"DOI":"10.13039\/501100004663","name":"Taiwan's Ministry of Science and Technology","doi-asserted-by":"crossref","award":["MOST105-2629-B-038-001"],"award-info":[{"award-number":["MOST105-2629-B-038-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan's Ministry of Science and Technology","doi-asserted-by":"crossref","award":["MOST105-2314-B-038-025"],"award-info":[{"award-number":["MOST105-2314-B-038-025"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan's Ministry of Science and Technology","doi-asserted-by":"crossref","award":["MOST104-2314-B-038-027-MY2"],"award-info":[{"award-number":["MOST104-2314-B-038-027-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan's Ministry of Science and Technology","doi-asserted-by":"crossref","award":["NSC102-2314-B-038-021-MY3"],"award-info":[{"award-number":["NSC102-2314-B-038-021-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Taiwan's Ministry of Health and Welfare Clinical Trial and Research Center of Excellence"}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.atherosclerosis.2017.05.030","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T16:01:03Z","timestamp":1495728063000},"page":"29-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Cirrhosis patients' stroke risks and adverse outcomes: Two nationwide studies"],"prefix":"10.1016","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0353-9434","authenticated-orcid":false,"given":"Hsin-Yun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Shun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chieh","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaur-Jong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chuan","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Giun","family":"Cherng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta-Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-0730","authenticated-orcid":false,"given":"Chien-Chang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.atherosclerosis.2017.05.030_bib1","first-page":"e38","article-title":"Heart disease and stroke statistics, 2016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.05.030_bib2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1052-3057(03)00042-9","article-title":"The influence of gender and age on disability following ischemic stroke: the Framingham study","volume":"12","author":"Kelly-Hayes","year":"2003","journal-title":"J.\u00a0Stroke Cerebrovasc. Dis."},{"issue":"9735","key":"10.1016\/j.atherosclerosis.2017.05.030_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0140-6736(10)60834-3","article-title":"Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study","volume":"376","author":"O'Donnell","year":"2010","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2017.05.030_bib4","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1016\/S2214-109X(13)70089-5","article-title":"Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010","volume":"1","author":"Krishnamurthi","year":"2013","journal-title":"Lancet Glob. Health"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.05.030_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jhep.2012.12.005","article-title":"The burden of liver disease in Europe: a review of available epidemiological data","volume":"58","author":"Blachier","year":"2013","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.atherosclerosis.2017.05.030_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12916-014-0145-y","article-title":"Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis","volume":"12","author":"Mokdad","year":"2014","journal-title":"BMC Med."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.05.030_bib7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s10286-006-0337-4","article-title":"Autonomic dysfunction and impaired cerebral autoregulation in cirrhosis","volume":"16","author":"Fr\u00f8kjaer","year":"2006","journal-title":"Clin. Auton. Res."},{"issue":"9","key":"10.1016\/j.atherosclerosis.2017.05.030_bib8","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1161\/STROKEAHA.111.617076","article-title":"Liver cirrhosis and risk of intracerebral hemorrhage: a 9-year follow-up study","volume":"42","author":"Lai","year":"2011","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.05.030_bib9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.clineuro.2007.11.010","article-title":"Spontaneous intracranial hemorrhage in cirrhotic patients","volume":"110","author":"Huang","year":"2008","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.atherosclerosis.2017.05.030_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-230X-8-16","article-title":"Liver cirrhosis, other liver diseases, and risk of hospitalisation for intracerebral haemorrhage: a Danish population-based case-control study","volume":"8","author":"Gr\u00f8nbaek","year":"2008","journal-title":"BMC Gastroenterol."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.05.030_bib11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.11.005","article-title":"Association between liver disease and intracranial hemorrhage","volume":"25","author":"Parikh","year":"2016","journal-title":"J.\u00a0Stroke Cerebrovasc. Dis."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2017.05.030_bib12","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jocn.2014.12.009","article-title":"High mortality in cirrhotic patients following hemorrhagic stroke","volume":"22","author":"Hung","year":"2015","journal-title":"J.\u00a0Clin. Neurosci."},{"issue":"4","key":"10.1016\/j.atherosclerosis.2017.05.030_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2176\/nmc.52.181","article-title":"Intracerebral hemorrhage in patients with chronic liver disease","volume":"52","author":"Hoya","year":"2012","journal-title":"Neurol. Med. Chir."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2017.05.030_bib14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1478-3231.2005.01002.x","article-title":"Reduced prevalence of ischemic events and abnormal supraortic flow patterns in patients with liver cirrhosis","volume":"25","author":"Berzigotti","year":"2005","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2017.05.030_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/MEG.0000000000000493","article-title":"Risk of cerebrovascular accident in patients with primary biliary cirrhosis: a systematic review and meta-analysis","volume":"28","author":"Ungprasert","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2017.05.030_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00004728-200201000-00010","article-title":"Is coagulopathic liver disease a factor in spontaneous cerebral hemorrhage?","volume":"26","author":"Lee","year":"2002","journal-title":"J.\u00a0Comput. Assist. Tomogr."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.05.030_bib17","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1478-3231.2010.02350.x","article-title":"Non-alcoholic cirrhosis and the risk of stroke: a 5-year follow-up study","volume":"31","author":"Chen","year":"2011","journal-title":"Liver Int."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2017.05.030_bib18","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/bjs.9639","article-title":"Outcomes after surgery in patients with previous stroke","volume":"101","author":"Liao","year":"2014","journal-title":"Br. J. Surg."},{"issue":"13","key":"10.1016\/j.atherosclerosis.2017.05.030_bib19","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/bjs.9312","article-title":"Postoperative adverse outcomes after non-hepatic surgery in patients with liver cirrhosis","volume":"100","author":"Lin","year":"2013","journal-title":"Br. J. Surg."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2017.05.030_bib20","doi-asserted-by":"crossref","first-page":"27682774","DOI":"10.1161\/STROKEAHA.110.595785","article-title":"Age- and gender-specific prevalence of cardiovascular risk factors in 40,102 patients with first-ever ischemic stroke: a nationwide Danish study","volume":"41","author":"Andersen","year":"2010","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.atherosclerosis.2017.05.030_bib21","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1161\/01.STR.31.8.1833","article-title":"Sex differences and similarities in the management and outcome of stroke patients","volume":"31","author":"Holroyd-Leduc","year":"2000","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.atherosclerosis.2017.05.030_bib22","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/intqhc\/mzv038","article-title":"Processes and outcomes of ischemic stroke care: the influence of hospital level of care","volume":"27","author":"Tung","year":"2015","journal-title":"Int. J. Qual. Health Care"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2017.05.030_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1586\/17476348.1.1.75","article-title":"Systemic effects of chronic obstructive pulmonary disease","volume":"1","author":"Halpin","year":"2007","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.atherosclerosis.2017.05.030_bib24","doi-asserted-by":"crossref","first-page":"26636","DOI":"10.1038\/srep26636","article-title":"Anemia increases the mortality risk in patients with stroke: a meta-analysis of cohort studies","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.atherosclerosis.2017.05.030_bib25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13049-014-0066-y","article-title":"Increased risk of ischemic stroke in patients with mild traumatic brain injury: a nationwide cohort study","volume":"22","author":"Lee","year":"2014","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.05.030_bib26","doi-asserted-by":"crossref","first-page":"e0152269","DOI":"10.1371\/journal.pone.0152269","article-title":"Vascular disease and risk stratification for ischemic stroke and all-cause death in heart failure patients without diagnosed atrial fibrillation: a nationwide cohort study","volume":"11","author":"Melgaard","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.atherosclerosis.2017.05.030_bib27","first-page":"105","article-title":"Cognitive impairment and stroke in elderly patients","volume":"12","author":"Lo","year":"2016","journal-title":"Vasc. Health Risk Manag."},{"issue":"7","key":"10.1016\/j.atherosclerosis.2017.05.030_bib28","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/ndt\/gfv009","article-title":"Chronic kidney disease and the risk of stroke: a systematic review and meta-analysis","volume":"30","author":"Masson","year":"2015","journal-title":"Nephrol. Dial. Transpl."},{"issue":"8","key":"10.1016\/j.atherosclerosis.2017.05.030_bib29","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1161\/STROKEAHA.115.010115","article-title":"Poststroke epilepsy is associated with a high mortality after a stroke at young age: follow-up of transient ischemic attack and stroke patients and unelucidated risk factor evaluation study","volume":"46","author":"Arntz","year":"2015","journal-title":"Stroke"},{"issue":"23","key":"10.1016\/j.atherosclerosis.2017.05.030_bib30","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.3748\/wjg.v20.i23.7223","article-title":"Comorbidity in cirrhosis","volume":"20","author":"Jepsen","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"7","key":"10.1016\/j.atherosclerosis.2017.05.030_bib31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.disamonth.2008.03.006","article-title":"Complications of cirrhosis","volume":"54","author":"Dong","year":"2008","journal-title":"Dis. Mon."},{"issue":"7","key":"10.1016\/j.atherosclerosis.2017.05.030_bib32","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/STR.0000000000000024","article-title":"Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Kernan","year":"2014","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2017.05.030_bib33","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1002\/pds.3359","article-title":"Effectiveness and safety of antiplatelet therapy in stroke recurrence prevention in patients with liver cirrhosis: a 2-year follow-up study","volume":"21","author":"Chen","year":"2012","journal-title":"Pharmacoepidemiol Drug Saf."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2017.05.030_bib34","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1161\/01.STR.28.12.2370","article-title":"Predisposing factors to enlargement of spontaneous intracerebral hematoma","volume":"28","author":"Kazui","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2017.05.030_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1423-0127-19-66","article-title":"Levels and values of circulating endothelial progenitor cells, soluble angiogenic factors, and mononuclear cell apoptosis in liver cirrhosis patients","volume":"19","author":"Chen","year":"2012","journal-title":"J.\u00a0Biomed. Sci."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2017.05.030_bib36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/ajg.2012.362","article-title":"Cardiovascular risk factors and systemic endothelial function in patients with cirrhosis","volume":"108","author":"Berzigotti","year":"2013","journal-title":"Am. J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.atherosclerosis.2017.05.030_bib37","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.dld.2014.01.003","article-title":"Progression to cirrhosis, hepatocellular carcinoma and liver-related mortality in chronic hepatitis B patients in Italy","volume":"46","author":"Ieluzzi","year":"2014","journal-title":"Dig. Liver Dis."},{"issue":"11\u201312","key":"10.1016\/j.atherosclerosis.2017.05.030_bib38","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1365-2036.2005.02691.x","article-title":"Systematic review: the model for end-stage liver disease \u2013 should it replace Child-Pugh's classification for assessing prognosis in cirrhosis?","volume":"22","author":"Cholongitas","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.atherosclerosis.2017.05.030_bib39","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/STROKEAHA.114.008422","article-title":"Efficacy of antiplatelet therapy in secondary prevention following lacunar stroke: pooled analysis of randomized trials","volume":"46","author":"Kwok","year":"2015","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2017.05.030_bib40","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMra1011170","article-title":"The coagulopathy of chronic liver disease","volume":"365","author":"Tripodi","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.05.030_bib41","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pds.2087","article-title":"Validation of the national health insurance research database with ischemic stroke cases in Taiwan","volume":"20","author":"Cheng","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915017302332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915017302332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:36:23Z","timestamp":1758155783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915017302332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":41,"alternative-id":["S0021915017302332"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.05.030","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cirrhosis patients' stroke risks and adverse outcomes: Two nationwide studies","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.05.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}