{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:07:57Z","timestamp":1790842077898,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Casa Sollievo della Sofferenza"},{"name":"SSPEC_PETTOELLO_PEDIATRIA, University of Foggia"}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.atherosclerosis.2017.06.028","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T20:46:36Z","timestamp":1497559596000},"page":"127-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Urea-induced ROS accelerate senescence in endothelial progenitor cells"],"prefix":"10.1016","volume":"263","author":[{"given":"Maria","family":"D'Apolito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Laura","family":"Colia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lasalvia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Capozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-9237","authenticated-orcid":false,"given":"Maria Pia","family":"Falcone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Pettoello-Mantovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brownlee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Bruna","family":"Maffione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3218-4476","authenticated-orcid":false,"given":"Ida","family":"Giardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib1","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0140-6736(14)60384-6","article-title":"Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure","volume":"383","author":"Ortiz","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrneph.2010.143","article-title":"Atherosclerosis in CKD: differences from the general population","volume":"6","author":"Dr\u00fceke","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib3","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1681\/ASN.V961018","article-title":"Myocyte\/capillary mismatch in the heart of uremic patients","volume":"9","author":"Amann","year":"1998","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/01.CIR.0000131515.03336.f8","article-title":"Role of endothelial dysfunction in atherosclerosis","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2017.06.028_bib5","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1681\/ASN.V12122747","article-title":"Oxidative stress and endothelial function in chronic renal failure","volume":"12","author":"Annuk","year":"2001","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib6","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1093\/emboj\/18.14.3964","article-title":"VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells","volume":"18","author":"Asahara","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib7","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1161\/01.CIR.0000018166.84319.55","article-title":"Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells","volume":"105","author":"Walter","year":"2002","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.06.028_bib8","doi-asserted-by":"crossref","first-page":"e9543","DOI":"10.1371\/journal.pone.0009543","article-title":"Culture modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism","volume":"5","author":"Yuen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib9","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1056\/NEJMoa051779","article-title":"Transcoronary transplantation of progenitor cells after myocardial infarction","volume":"355","author":"Assmus","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib10","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJMoa022287","article-title":"Circulating endothelial progenitor cells, vascular function, and cardiovascular risk","volume":"348","author":"Hill","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib11","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1161\/01.CIR.0000039526.42991.93","article-title":"Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures","volume":"106","author":"Tepper","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib12","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1161\/01.CIR.0000077911.81151.30","article-title":"Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation","volume":"107","author":"Strehlow","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/01.CIR.0000082924.75945.48","article-title":"Aging, progenitor cell exhaustion, and atherosclerosis","volume":"108","author":"Rauscher","year":"2003","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.atherosclerosis.2017.06.028_bib14","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1681\/ASN.2009111119","article-title":"Dysfunctional endothelial progenitor cells in chronic kidney disease","volume":"21","author":"Goligorsky","year":"2010","journal-title":"Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/ndt\/gfp643","article-title":"Endothelial progenitor cells in chronic kidney disease","volume":"25","author":"Bahlmann","year":"2010","journal-title":"Nephrol. Dial. Transpl."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2017.06.028_bib16","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1523-1755.2004.00784.x","article-title":"Uremia causes endothelial progenitor cell deficiency","volume":"66","author":"de Groot","year":"2004","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2017.06.028_bib17","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.atherosclerosis.2015.01.034","article-title":"Urea-induced ROS cause endothelial dysfunction in chronic renal failure","volume":"239","author":"D'Apolito","year":"2015","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.atherosclerosis.2017.06.028_bib18","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nm1388","article-title":"Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells","volume":"12","author":"Ito","year":"2006","journal-title":"Nat. Med. Apr"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib19","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/01.CIR.0000058702.69484.A0","article-title":"Peripheral blood \u201cendothelial progenitor cells\u201d are derived from monocyte\/macrophages and secrete angiogenic growth factors","volume":"107","author":"Rehman","year":"2003","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.atherosclerosis.2017.06.028_bib20","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.2337\/db06-0369","article-title":"Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt\/FoxO signaling","volume":"55","author":"Marchetti","year":"2006","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2017.06.028_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1172\/JCI37672","article-title":"Urea induced ROS generation causes insulin resistance in mice with chronic renal failure","volume":"120","author":"D'Apolito","year":"2010","journal-title":"J.\u00a0Clin. Investig."},{"issue":"9","key":"10.1016\/j.atherosclerosis.2017.06.028_bib22","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1002\/stem.145","article-title":"Adenoviral-mediated endothelial precursor cell delivery of soluble CD115 suppresses human prostate cancer xenograft growth in mice","volume":"27","author":"Lucas","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib23","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1002\/hep.25938","article-title":"Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent","volume":"56","author":"Aoyama","year":"2012","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2017.06.028_bib24","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1165\/rcmb.2011-0418OC","article-title":"The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation","volume":"47","author":"D","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"Pt 24","key":"10.1016\/j.atherosclerosis.2017.06.028_bib25","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1242\/jcs.073783","article-title":"SIRT2 regulates NF-\u03baB dependent gene expression through deacetylation of p65 Lys310","volume":"123","author":"Rothgiesser","year":"2010","journal-title":"J.\u00a0Cell. Sci."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib26","series-title":"The History, Physical, and Laboratory Examinations","first-page":"874","article-title":"BUN and creatinine clinical methods","author":"Hosten","year":"1990"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2017.06.028_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2337\/diabetes.55.01.06.db05-0894","article-title":"Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy","volume":"55","author":"Susztak","year":"2006","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.atherosclerosis.2017.06.028_bib28","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.2337\/db05-1477","article-title":"Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress","volume":"55","author":"Menini","year":"2006","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.atherosclerosis.2017.06.028_bib29","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1172\/JCI13579","article-title":"Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance","volume":"117","author":"Choi","year":"2007","journal-title":"J.\u00a0Clin. Invest"},{"issue":"6779","key":"10.1016\/j.atherosclerosis.2017.06.028_bib30","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib31","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.RES.86.5.494","article-title":"NAD(P)H oxidase role in cardiovascular biology and disease","volume":"86","author":"Griendling","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib32","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/cvr\/cvt182","article-title":"The constituents and mechanisms of generation of \u2018endothelial cell\u2014colony forming units\u2019","volume":"100","author":"Padfield","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000256837.40544.4a","article-title":"Vascular cell senescence: contribution to atherosclerosis","volume":"100","author":"Minamino","year":"2007","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.atherosclerosis.2017.06.028_bib34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/157340308786349435","article-title":"Endothelial progenitor cells dysfunction and senescence: contribution to oxidative stress","volume":"4","author":"Imanishi","year":"2008","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib35","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Coppe","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrc2560","article-title":"Senescence-messaging secretome: SMS-ing cellular stress","volume":"9","author":"Kuilman","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"20","key":"10.1016\/j.atherosclerosis.2017.06.028_bib37","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1101\/gad.17276711","article-title":"Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity","volume":"25","author":"Chien","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib38","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1681\/ASN.2007121377","article-title":"A\u00a0bench to bedside view of uremic toxins","volume":"19","author":"Vanholder","year":"2008","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1681\/ASN.2004060495","article-title":"Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice","volume":"16","author":"Massy","year":"2005","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.atherosclerosis.2016.12.022","article-title":"Uremia modulates the phenotype of aortic smooth muscle cells","volume":"257","author":"Madsen","year":"2017","journal-title":"Atherosclerosis"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2017.06.028_bib41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/sdi.12515","article-title":"Reconsidering the lack of urea toxicity in dialysis patients","volume":"29","author":"Massy","year":"2016","journal-title":"Semin. Dial."},{"issue":"5","key":"10.1016\/j.atherosclerosis.2017.06.028_bib42","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.mcna.2011.06.002","article-title":"Insulin resistance: the link between obesity and cardiovascular disease","volume":"95","author":"Reaven","year":"2011","journal-title":"Med. Clin. North. Am."},{"issue":"9","key":"10.1016\/j.atherosclerosis.2017.06.028_bib43","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.metabol.2012.02.005","article-title":"Race-ethnic differences in adipokine levels: the Study of Women's Health Across the Nation (SWAN)","volume":"61","author":"Khan","year":"2012","journal-title":"Metabolism"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib44","series-title":"The History, Physical, and Laboratory Examinations","first-page":"874","article-title":"BUN and creatinine clinical methods","author":"Hosten","year":"1990"},{"issue":"7","key":"10.1016\/j.atherosclerosis.2017.06.028_bib45","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2011.06.033","article-title":"Crosstalk between mitochondria and NADPH oxidases","volume":"51","author":"Dikalov","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib46","doi-asserted-by":"crossref","first-page":"9491","DOI":"10.1073\/pnas.0402961101","article-title":"High urea and NaCl carbonylate proteins in renal cells in culture and in\u00a0vivo, and high urea causes 8-oxoguanine lesions in their DNA","volume":"101","author":"Zhang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.atherosclerosis.2017.06.028_bib47","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1681\/ASN.2012030254","article-title":"Protein carbamylation predicts mortality in ESRD","volume":"24","author":"Koeth","year":"2013","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"issue":"10","key":"10.1016\/j.atherosclerosis.2017.06.028_bib48","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/nm1637","article-title":"Protein carbamylation links inflammation, smoking, uremia and atherogenesis","volume":"13","author":"Wang","year":"2007","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2017.06.028_bib49","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/j.1523-1755.2004.00456.x","article-title":"Uremia and insulin resistance: N-carbamoyl-asparagine decreases insulin-sensitive glucose uptake in rat adipocytes","volume":"65","author":"Kraus","year":"2004","journal-title":"Kidney Int."},{"issue":"9","key":"10.1016\/j.atherosclerosis.2017.06.028_bib50","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.2337\/db15-0084","article-title":"GLP-1 cleavage product reverses persistent ROS generation after transient hyperglycemia by disrupting an ROS-generating feedback loop","volume":"64","author":"Giacco","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib51","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1161\/CIRCRESAHA.116.306923","article-title":"Molecular and cellular mechanisms of cardiovascular disorders in diabetes","volume":"118","author":"Shah","year":"2016","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.atherosclerosis.2017.06.028_bib52","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1253\/circj.70.1076","article-title":"Hyperglycemia accelerated endothelial progenitor cell senescence via the activation of p38 mitogen-activated protein kinase","volume":"70","author":"Kuki","year":"2006","journal-title":"Circ. J."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2017.06.028_bib53","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00063-006-1125-6","article-title":"Value of diabetes as an independent predictor of death in subjects with end-stage renal disease","volume":"101","author":"Koc","year":"2006","journal-title":"Med. Klin. (Munich)"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib54","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1111\/j.1600-6143.2006.01555.x","article-title":"Kidney transplantation substantially improves endothelial progenitor cell dysfunction in patients with end-stage renal disease","volume":"6","author":"Herbrig","year":"2006","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib55","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/01.tp.0000198418.06383.e8","article-title":"Endothelial progenitor cells in kidney transplant recipients","volume":"81","author":"Steiner","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib56","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1161\/01.ATV.0000133488.56221.4a","article-title":"Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure","volume":"24","author":"Choi","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib57","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/ndt\/gfp358","article-title":"Dialysis modality is independently associated with circulating endothelial progenitor cells in end-stage renal diseases patients","volume":"25","author":"Ueno","year":"2009","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib58","doi-asserted-by":"crossref","first-page":"F679","DOI":"10.1152\/ajprenal.00127.2005","article-title":"Nocturnal hemodialysis is associated with restoration of impaired endothelial progenitor cell biology in end-stage renal disease","volume":"289","author":"Chan","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.atherosclerosis.2017.06.028_bib59","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.2215\/CJN.10911210","article-title":"Nocturnal hemodialysis is associated with restoration of early-outgrowth endothelial progenitor-like cell function","volume":"6","author":"Yuen","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2017.06.028_bib60","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/ndt\/gfh813","article-title":"Chronic kidney disease as a cause of cardiovascular morbidity and mortality","volume":"20","author":"Vanholder","year":"2005","journal-title":"Nephrol. Dial. Transpl."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915017302770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915017302770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:37:21Z","timestamp":1758155841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915017302770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":60,"alternative-id":["S0021915017302770"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.06.028","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urea-induced ROS accelerate senescence in endothelial progenitor cells","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.06.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}