{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T08:38:18Z","timestamp":1774514298288,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Center of Competence in Research, NCCR Kidney.ch","award":["403-11-21"],"award-info":[{"award-number":["403-11-21"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","atherosclerosis-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.atherosclerosis.2017.08.012","type":"journal-article","created":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T07:30:40Z","timestamp":1503127840000},"page":"78-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"special_numbering":"C","title":["Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1\/NRF2\/NQO1 activation"],"prefix":"10.1016","volume":"265","author":[{"given":"Parisa","family":"Aghagolzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramin","family":"Radpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Bachtler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Lister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Feelisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Pasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib1","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/ndt\/gfp755","article-title":"Sodium thiosulfate delays the progression of coronary artery calcification in haemodialysis patients","volume":"25","author":"Adirekkiat","year":"2010","journal-title":"Nephrol. Dialysis, Transplant. Official Publ. Eur. Dialysis Transpl. Assoc. - Eur. Ren. Assoc."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.atherosclerosis.2016.05.044","article-title":"Calcification of vascular smooth muscle cells is induced by secondary calciprotein particles and enhanced by tumor necrosis factor-alpha","volume":"251","author":"Aghagolzadeh","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib3","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/ajh\/hpu225","article-title":"Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification","volume":"28","author":"Agharazii","year":"2014","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00210-013-0920-x","article-title":"Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in\u00a0vitro","volume":"387","author":"Al-Magableh","year":"2014","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib5","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/ndt\/gfr560","article-title":"Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease","volume":"27","author":"Aminzadeh","year":"2012","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib6","first-page":"159680","article-title":"Role of hydrogen sulfide in the pathology of inflammation","volume":"2012","author":"Bhatia","year":"2012","journal-title":"Sci. (Cairo)"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib7","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1161\/hy1001.096358","article-title":"Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease","volume":"38","author":"Blacher","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/nep.12350","article-title":"Relative abundance of fetuin- a in peritoneal dialysis effluent and its association with in situ formation of calciprotein particles: an observational pilot study","volume":"20","author":"Cai","year":"2015","journal-title":"Nephrol. Carlt."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib10","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1073\/pnas.1115634109","article-title":"Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production","volume":"109","author":"Fu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib11","doi-asserted-by":"crossref","first-page":"R1479","DOI":"10.1152\/ajpregu.90566.2008","article-title":"Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values","volume":"295","author":"Furne","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib12","doi-asserted-by":"crossref","first-page":"R165","DOI":"10.1186\/cc9257","article-title":"Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats","volume":"14","author":"Ganster","year":"2010","journal-title":"Crit. Care"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bbrc.2004.04.094","article-title":"Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol","volume":"318","author":"Geng","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib14","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1097\/01.ASN.0000145894.57533.C4","article-title":"Vascular calcification mechanisms","volume":"15","author":"Giachelli","year":"2004","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2215\/CJN.07450714","article-title":"Vascular calcification in patients with nondialysis CKD over 3 years","volume":"10","author":"Gorriz","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib16","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1089\/ars.2010.3821","article-title":"Hydrogen sulfide ameliorates tobacco smoke-induced oxidative stress and emphysema in mice","volume":"15","author":"Han","year":"2011","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib17","doi-asserted-by":"crossref","first-page":"14815","DOI":"10.1074\/jbc.M709938200","article-title":"Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles","volume":"283","author":"Heiss","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib18","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1089\/ars.2010.3222","article-title":"Discovery of the negative regulator of Nrf2, Keap1: a historical overview","volume":"13","author":"Itoh","year":"2010","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib19","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.freeradbiomed.2004.02.074","article-title":"Nrf2 signaling in coordinated activation of antioxidant gene expression","volume":"36","author":"Jaiswal","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0891-5849(00)00306-3","article-title":"Regulation of genes encoding NAD(P)H:quinone oxidoreductases","volume":"29","author":"Jaiswal","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2008.2282","article-title":"Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib22","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1097\/01.ASN.0000128966.55133.69","article-title":"Kidney dysfunction, inflammation, and coronary events: a prospective study","volume":"15","author":"Knight","year":"2004","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1128\/MCB.26.1.221-229.2006","article-title":"Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1","volume":"26","author":"Kobayashi","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib24","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/ars.2005.7.385","article-title":"Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation","volume":"7","author":"Kobayashi","year":"2005","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.niox.2013.07.002","article-title":"Hydrogen sulfide chemical biology: pathophysiological roles and detection","volume":"35","author":"Kolluru","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/386078a0","article-title":"Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein","volume":"386","author":"Luo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3164\/jcbn.15-111","article-title":"Redox signaling regulated by electrophiles and reactive sulfur species","volume":"58","author":"Nishida","year":"2016","journal-title":"J.\u00a0Clin. Biochem. Nutr."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib28","doi-asserted-by":"crossref","first-page":"R592","DOI":"10.1152\/ajpregu.00421.2012","article-title":"Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensing","volume":"305","author":"Olson","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.niox.2014.05.012","article-title":"Controversies and conundrums in hydrogen sulfide biology","volume":"41","author":"Olson","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib30","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1242\/jeb.02480","article-title":"Hydrogen sulfide as an oxygen sensor\/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation","volume":"209","author":"Olson","year":"2006","journal-title":"J.\u00a0Exp. Biol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib31","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/ki.2008.455","article-title":"Sodium thiosulfate prevents vascular calcifications in uremic rats","volume":"74","author":"Pasch","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib32","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1093\/ndt\/gfp378","article-title":"Hydrogen sulphide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes","volume":"24","author":"Perna","year":"2009","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib33","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1097\/01.ASN.0000141960.01035.28","article-title":"Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD","volume":"15","author":"Reynolds","year":"2004","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/ki.2010.390","article-title":"Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in\u00a0vitro","volume":"79","author":"Sage","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/nep.12021","article-title":"Serum fetuin-a concentration and fetuin-a-containing calciprotein particles in patients with chronic inflammatory disease and renal failure","volume":"18","author":"Smith","year":"2013","journal-title":"Nephrol. Carlt."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib36","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1523-1755.2005.00200.x","article-title":"IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia\u2013the good, the bad, and the ugly","volume":"67","author":"Stenvinkel","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib37","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.freeradbiomed.2007.02.017","article-title":"Action of Nrf2 and Keap1 in are-mediated NQO1 expression by quercetin","volume":"42","author":"Tanigawa","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrd4433","article-title":"Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter","volume":"14","author":"Wallace","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib39","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1745-7254.2006.00283.x","article-title":"Hydrogen sulfide ameliorates vascular calcification induced by vitamin D3 plus nicotine in rats","volume":"27","author":"Wu","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib41","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.freeradbiomed.2011.02.016","article-title":"Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage-implications for the treatment of osteoporosis","volume":"50","author":"Xu","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib42","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib43","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/ki.2011.212","article-title":"Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells","volume":"80","author":"Zavaczki","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib44","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1128\/MCB.23.22.8137-8151.2003","article-title":"Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress","volume":"23","author":"Zhang","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib45","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1016\/j.transproceed.2016.10.023","article-title":"Resveratrol ameliorated vascular calcification by regulating Sirt-1 and Nrf2","volume":"48","author":"Zhang","year":"2016","journal-title":"Transpl. Proc."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib46","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.atherosclerosis.2017.08.012_bib47","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/jcb.24049","article-title":"Lanthanum chloride bidirectionally influences calcification in bovine vascular smooth muscle cells","volume":"113","author":"Zhao","year":"2012","journal-title":"J.\u00a0Cell Biochem."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915017312340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915017312340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T11:13:05Z","timestamp":1719400385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915017312340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":47,"alternative-id":["S0021915017312340"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.08.012","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1\/NRF2\/NQO1 activation","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}