{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:32:26Z","timestamp":1763037146352,"version":"3.40.5"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","atherosclerosis-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.atherosclerosis.2018.01.021","type":"journal-article","created":{"date-parts":[[2018,1,27]],"date-time":"2018-01-27T09:57:38Z","timestamp":1517047058000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Post-transplant hypocomplementemia: A novel marker of cardiovascular risk in kidney transplant recipients?"],"prefix":"10.1016","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8001","authenticated-orcid":false,"given":"Guillermo","family":"Maestro de la Calle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Fern\u00e1ndez-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"L\u00f3pez-Medrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Polanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"San Juan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Ruiz-Merlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Orig\u00fcen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Paz-Artal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amado","family":"Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Aguado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib1","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1681\/ASN.V1191735","article-title":"Explained and unexplained ischemic heart disease risk after renal transplantation","volume":"11","author":"Kasiske","year":"2000","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1523-1755.2004.00751.x","article-title":"Predicting coronary heart disease in renal transplant recipients: a prospective study","volume":"66","author":"Ducloux","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib3","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1097\/TP.0000000000000568","article-title":"Homoarginine and clinical outcomes in renal transplant recipients: results from the assessment of lescol in renal transplantation study","volume":"99","author":"Drechsler","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib4","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1097\/01.TP.0000061602.03327.E2","article-title":"Decreased renal function is a strong risk factor for cardiovascular death after renal transplantation","volume":"75","author":"Meier-Kriesche","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib5","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/infdis\/jit064","article-title":"Cytomegalovirus exposure and cardiovascular disease in kidney transplant recipients","volume":"207","author":"Courivaud","year":"2013","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib6","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.2165\/00003495-200464180-00004","article-title":"Effect of immunosuppressive agents on long-term survival of renal transplant recipients: focus on the cardiovascular risk","volume":"64","author":"Boots","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.molimm.2014.06.031","article-title":"The complement system in human cardiometabolic disease","volume":"61","author":"Hertle","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.atherosclerosis.2015.05.038","article-title":"The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis","volume":"241","author":"Hovland","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.semnephrol.2013.08.001","article-title":"Overview of complement activation and regulation","volume":"33","author":"Noris","year":"2013","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1538-7836.2010.04172.x","article-title":"Complement in atherosclerosis: friend or foe?","volume":"9","author":"Speidl","year":"2011","journal-title":"J.\u00a0Thromb. Haemostasis"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0008-6363(03)00345-6","article-title":"Dendritic cells in the arterial wall express C1q: potential significance in atherogenesis","volume":"60","author":"Cao","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.trre.2014.03.001","article-title":"Complement modulation in solid-organ transplantation","volume":"28","author":"Touzot","year":"2014","journal-title":"Transplant. Rev."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib14","first-page":"333","article-title":"The complement system in liver diseases","volume":"3","author":"Qin","year":"2006","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.clinbiochem.2012.09.012","article-title":"Complement and atherosclerosis-united to the point of no return?","volume":"46","author":"Torzewski","year":"2013","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0002-9343(99)80314-3","article-title":"Association of serum C3 levels with the risk of myocardial infarction","volume":"98","author":"Muscari","year":"1995","journal-title":"Am. J. Med."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib17","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/01.hjr.0000244582.30421.b2","article-title":"Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study","volume":"14","author":"Engstrom","year":"2007","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib18","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.metabol.2009.09.006","article-title":"Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population","volume":"59","author":"Onat","year":"2010","journal-title":"Metabolism"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib19","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.amjcard.2006.11.034","article-title":"Serum complement C3\/C4 ratio, a novel marker for recurrent cardiovascular events","volume":"99","author":"Palikhe","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.amjcard.2007.02.075","article-title":"Usefulness of the serum complement component C4 as a predictor of stroke in patients with known or suspected coronary artery disease referred for coronary angiography","volume":"100","author":"Cavusoglu","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib21","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12967-016-0995-5","article-title":"Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients","volume":"14","author":"Poppelaars","year":"2016","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib22","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1111\/j.1600-6143.2012.04192.x","article-title":"Monitoring of immunoglobulin levels identifies kidney transplant recipients at high risk of infection","volume":"12","author":"Fern\u00e1ndez-Ruiz","year":"2012","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/ajt.12055","article-title":"Hypocomplementemia in kidney transplant recipients: impact on the risk of infectious complications","volume":"13","author":"Fern\u00e1ndez-Ruiz","year":"2013","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A\u00a0new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib25","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jacc.2012.08.001","article-title":"Third universal definition of myocardial infarction","volume":"60","author":"Thygesen","year":"2012","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib26","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/STR.0b013e318284056a","article-title":"Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"44","author":"Jauch","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00041433-200310000-00008","article-title":"Role of complement activation in atherosclerosis","volume":"14","author":"Oksjoki","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib28","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/hq0701.092160","article-title":"Complement components, but not complement inhibitors, are upregulated in atherosclerotic plaques","volume":"21","author":"Yasojima","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.atherosclerosis.2006.01.009","article-title":"The metabolic syndrome in relation to complement component 3 and postprandial lipemia in patients from an outpatient lipid clinic and healthy volunteers","volume":"190","author":"van Oostrom","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1177\/0961203316640922","article-title":"Autoantibodies, complement and type I interferon as biomarkers for personalized medicine in SLE","volume":"25","author":"Biesen","year":"2016","journal-title":"Lupus"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib31","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/acr.22271","article-title":"Risk factors in the progression of subclinical atherosclerosis in women with systemic lupus erythematosus","volume":"66","author":"Lertratanakul","year":"2014","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib32","first-page":"1","article-title":"Immune complexes of \u00df-2-glicoprotein I bounded to IgA: a novel marker able to predict thrombosis after renal transplantation in patients with antiphospholipid antibodies","author":"Serrano","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/CIRCULATIONAHA.106.678342","article-title":"Chronic kidney disease: effects on the cardiovascular system","volume":"116","author":"Schiffrin","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib34","first-page":"17","article-title":"Immunological evaluation of renal transplant patients: changes in levels of beta-2-microglobulin, immunoglobulins and complement components during graft rejection","volume":"12","author":"Barnes","year":"1983","journal-title":"J.\u00a0Clin. Lab. Immunol."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib35","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/bjs.1800670716","article-title":"Predictive value of serum complement (C3) in renal allograft rejection","volume":"67","author":"Kumar","year":"1980","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib36","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1056\/NEJMoa1107477","article-title":"C-reactive protein, fibrinogen, and cardiovascular disease prediction","volume":"367","author":"Emerging Risk Factors","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/01.CIR.95.1.97","article-title":"C-reactive protein colocalizes with complement in human hearts during acute myocardial infarction","volume":"95","author":"Lagrand","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2018.01.021_bib38","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1084\/jem.190.12.1733","article-title":"C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction","volume":"190","author":"Griselli","year":"1999","journal-title":"J.\u00a0Exp. Med."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915018300212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915018300212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T09:12:33Z","timestamp":1660381953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915018300212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":38,"alternative-id":["S0021915018300212"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2018.01.021","relation":{},"ISSN":["0021-9150"],"issn-type":[{"type":"print","value":"0021-9150"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Post-transplant hypocomplementemia: A novel marker of cardiovascular risk in kidney transplant recipients?","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2018.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}