{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:36:50Z","timestamp":1790087810250,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Sociedad Mexicana de Nutrici\u00f3n y Endocrinolog\u00eda"},{"DOI":"10.13039\/501100007517","name":"ISSSTE","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007517","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004881","name":"IMSS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.atherosclerosis.2018.06.007","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T09:45:55Z","timestamp":1538127955000},"page":"517-523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The development of the Mexican Familial Hypercholesterolemia (FH) National Registry"],"prefix":"10.1016","volume":"277","author":[{"given":"Roopa","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandro J.","family":"Martagon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela A.","family":"Galan Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Gonzalez Retana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Martinez-Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsenio","family":"Vargas Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Vazquez-Cardenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-0241","authenticated-orcid":false,"given":"Carlos A.","family":"Aguilar-Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s11883-014-0482-5","article-title":"Familial hypercholesterolemia\u2014Epidemiology, diagnosis, and screening","volume":"17","author":"Singh","year":"2015","journal-title":"Curr. Atherosclerosis Rep."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/MOL.0000000000000300","article-title":"A\u00a0systematic review of current studies in patients with familial hypercholesterolemia by use of national familial hypercholesterolemia registries","volume":"27","author":"Mundal","year":"2016","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib3","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/eht273","article-title":"Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society","volume":"34","author":"Nordestgaard","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/MOL.0000000000000325","article-title":"Diagnostic scoring for familial hypercholesterolaemia in practice","volume":"27","author":"Haralambos","year":"2016","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib5","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1136\/bmj.303.6807.893","article-title":"Risk of fatal coronary heart disease in familial hypercholesterolaemia","volume":"303","author":"Scientific Steering Committee on behalf of the Simon Broome Register Group","year":"1991","journal-title":"BMJ"},{"issue":"1993","key":"10.1016\/j.atherosclerosis.2018.06.007_bib6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0002-9149(93)90155-6","article-title":"Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics","volume":"72","author":"Williams","year":"1993","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib7","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1194\/jlr.R072231","article-title":"The panorama of familial hypercholesterolemia in Latin America: a systematic review","volume":"57","author":"Mehta","year":"2016","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.atherosclerosis.2015.09.021","article-title":"Familial hypercholesterolaemia: a global call to arms","volume":"243","author":"Vallejo-Vaz","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosissup.2016.10.001","article-title":"Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration","volume":"22","author":"Vallejo-Vaz","year":"2016","journal-title":"Atheroscler Suppl Dec"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib10","series-title":"Frequently Asked Questions about Medical and Public Health Registries","author":"National Committee on Vital and Health Statistics","year":"2012"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib11","series-title":"Registries for Evaluating Patient Outcomes: a User's Guide [Internet]","year":"2014"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/MOL.0000000000000398","article-title":"The role of registries and genetic databases in familial hypercholesterolemia","volume":"28","author":"Kindt","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib13","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1136\/jmg.2006.038356","article-title":"Genetic causes of Familial Hypercholesterolaemia in UK patients: relation to plasma lipid levels and coronary heart disease risk","volume":"43","author":"Humphries","year":"2006","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/archdischild-2015-308570","article-title":"The UK paediatric familial hypercholesterolaemia register: preliminary data","volume":"102","author":"Ramaswami","year":"2017","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib15","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1177\/2047487316666371","article-title":"2016. Cardiovascular disease in patients with genotyped familial hypercholesterolemia in Norway during 1994\u20132009, a registry study","volume":"23","author":"Mundal","year":"2016","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0140-6736(00)03587-X","article-title":"Review of first 5 years of screening for familial hypercholesterolaemia in The Netherlands","volume":"357","author":"Umans-Eckenhausen","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib17","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ahj.2013.12.008","article-title":"Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry","volume":"167","author":"O'Brien","year":"2014","journal-title":"Am. Heart J."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib18","first-page":"326","article-title":"The british columbia familial hypercholesterolemia registry","volume":"55","author":"Wong","year":"2013","journal-title":"BCMJ"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1476-511X-10-94","article-title":"Clinical characteristics and evaluation of LDL cholesterol treatment of the Spanish familial hypercholesterolemia longitudinal cohort study (SAFEHEART)","volume":"10","author":"Mata","year":"2011","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jacl.2014.11.008","article-title":"Familial hypercholesterolemia mutations in the Middle Eastern and North African region: a need for a national registry","volume":"9","author":"Bamimore","year":"2015","journal-title":"J\u00a0Clin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib21","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.5551\/jat.37507","article-title":"Design of the familial hypercholesterolaemia Australasia network registry: creating opportunities for greater international collaboration","volume":"24","author":"Bellgard","year":"2017","journal-title":"J.\u00a0Atherosclerosis Thromb."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib22","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/BF03401525","article-title":"An insight into familial hypercholesterolemia in Greece: rationale and design of the Hellenic Familial Hypercholesterolemia Registry (Hellas-FH)","volume":"16","author":"Rizos","year":"2017","journal-title":"Hormones (Basel)"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.5543\/tkda.2017.25800","article-title":"The rationale and design of the national familial hypercholesterolemia registries in Turkey: a-HIT1 and A-HIT2 studies","volume":"45","author":"Kay\u0131k\u00e7\u0131o\u011flu","year":"2017","journal-title":"Turk Kardiyol. Dernegi Arsivi"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2174\/1874192401711010066","article-title":"The spectrum of familial hypercholesterolemia (FH) in Saudi Arabia: prime time for patient FH registry","volume":"11","author":"Alallaf","year":"2017","journal-title":"Open Cardiovasc. Med. J."},{"issue":"29","key":"10.1016\/j.atherosclerosis.2018.06.007_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/MOL.0000000000000496","article-title":"Familial hypercholesterolemia: experience from France","volume":"2018","author":"Rabes","year":"2018","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/archdischild-2015-308570","article-title":"The UK paediatric familial hypercholesterolaemia register: preliminary data","volume":"102","author":"Ramaswami","year":"2017","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib27","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIRCULATIONAHA.110.990929","article-title":"Pregnancy outcomes in familial hypercholesterolemia. A registry-based study","volume":"124","author":"Toleikyte","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/2047487316676135","article-title":"Cardiovascular disease mortality in patients with genetically verified familial hypercholesterolemia in Norway during 1992\u20132013","volume":"24","author":"Mundal","year":"2017","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib29","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.clinthera.2016.05.006","article-title":"Cardiovascular disease risk associated with familial hypercholesterolemia: a systematic review of the literature","volume":"38","author":"Wong","year":"2016","journal-title":"Clin. Therapeut."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/CIRCGENETICS.116.001381","article-title":"Treatment gaps in adults with heterozygous familial hypercholesterolemia in the United States: data from the CASCADE-FH registry","volume":"9","author":"deGoma","year":"2016","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.atherosclerosis.2017.10.006","article-title":"Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH patient registry","volume":"267","author":"Amrock","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib32","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/MOL.0000000000000398","article-title":"The role of registries and genetic databases in familial hypercholesterolemia","volume":"28","author":"Kindt","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"issue":"2016","key":"10.1016\/j.atherosclerosis.2018.06.007_bib33","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1161\/ATVBAHA.116.307514","article-title":"Coronary heart disease, peripheral arterial disease, and stroke in familial hypercholesterolaemia: insights from the SAFEHEART Registry (Spanish Familial Hypercholesterolaemia Cohort Study)","volume":"36","author":"Perez de Isla","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib34","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1161\/CIR.0000000000000297","article-title":"The agenda for familial hypercholesterolemia: a scientific statement from the American Heart Association","volume":"132","author":"Gidding","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib35","first-page":"1471","article-title":"Canadian Cardiovascular Society position statement on familial hypercholesterolemia","volume":"30","author":"Genest","year":"2014","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib36","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.jacc.2016.03.520","article-title":"Diagnostic yield and clinical utility of sequencing familial hypercholesterolemia genes in patients with severe hypercholesterolemia","volume":"67","author":"Khera","year":"2016","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib37","first-page":"s220","article-title":"Sistema de salud de M\u00e9xico","volume":"53","author":"G\u00f3mez-Dant\u00e9s","year":"2011","journal-title":"Salud Publica Mex."},{"key":"10.1016\/j.atherosclerosis.2018.06.007_bib38","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jacl.2016.11.004","article-title":"Clinical and molecular aspects of familial hypercholesterolemia in Ibero-American countries","volume":"11","author":"Santos","year":"2017","journal-title":"J\u00a0Clin Lipidol"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915018303174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915018303174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:38:29Z","timestamp":1758155909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915018303174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":38,"alternative-id":["S0021915018303174"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2018.06.007","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The development of the Mexican Familial Hypercholesterolemia (FH) National Registry","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2018.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}