{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:55:58Z","timestamp":1783716958802,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","atherosclerosis-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.atherosclerosis.2018.12.027","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T20:52:28Z","timestamp":1546635148000},"page":"127-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Dual roles of heparanase in human carotid plaque calcification"],"prefix":"10.1016","volume":"283","author":[{"given":"Silvia","family":"Aldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn\u00e9a","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Kronqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariette","family":"Lengquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"L\u00f6fling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0708-9530","authenticated-orcid":false,"given":"Lasse","family":"Folkersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubica P.","family":"Matic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-2634","authenticated-orcid":false,"given":"Lars","family":"Maegdefessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Henrik","family":"Grinnemo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"\u00d6sterholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Hedin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib1","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1161\/CIRCULATIONAHA.107.732867","article-title":"Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo","volume":"116","author":"Aikawa","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jcmg.2017.03.005","article-title":"Coronary artery calcification: from mechanism to molecular imaging","volume":"10","author":"Nakahara","year":"2017","journal-title":"JACC Cardiovasc. Imag."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib3","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jvs.2009.08.072","article-title":"Systematic review on the association between calcification in carotid plaques and clinical ischemic symptoms","volume":"51","author":"Kwee","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/joim.12448","article-title":"Gene expression signatures, pathways and networks in carotid atherosclerosis","volume":"279","author":"Perisic","year":"2016","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib5","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/hh2401.101070","article-title":"Smooth muscle cell phenotypic transition associated with calcification: upregulation of cbfa1 and downregulation of smooth muscle lineage markers","volume":"89","author":"Steitz","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/path.1743","article-title":"Transdifferentiation of smooth muscle cells into chondrocytes in atherosclerotic arteries in situ: implications for diffuse intimal calcification","volume":"205","author":"Bobryshev","year":"2005","journal-title":"J. Pathol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib7","doi-asserted-by":"crossref","first-page":"11201","DOI":"10.1073\/pnas.1932554100","article-title":"Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads","volume":"100","author":"Doherty","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib8","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/nature05817","article-title":"Heparan sulphate proteoglycans fine-tune mammalian physiology","volume":"446","author":"Bishop","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200604035","article-title":"Interactions between heparan sulfate and proteins: the concept of specificity","volume":"174","author":"Kreuger","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/bs.ircmb.2016.02.009","article-title":"Heparan sulfate: biosynthesis, structure, and function","volume":"325","author":"Li","year":"2016","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s004410051258","article-title":"Alterations of matrix- and cell-associated proteoglycans inhibit osteogenesis and growth response to fibroblast growth factor-2 in cultured rat mandibular condyle and calvaria","volume":"295","author":"Molteni","year":"1999","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib12","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1091\/mbc.e10-04-0348","article-title":"Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerization","volume":"21","author":"Kuo","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib13","doi-asserted-by":"crossref","first-page":"26233","DOI":"10.1074\/jbc.M110.122069","article-title":"Synergism between wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase\/akt\/runx2 pathway","volume":"285","author":"Ling","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib14","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.biocel.2005.03.006","article-title":"The osteoblast-heparan sulfate axis: control of the bone cell lineage","volume":"37","author":"Cool","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib15","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/10518","article-title":"Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis","volume":"5","author":"Vlodavsky","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib16","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.biocel.2006.06.004","article-title":"Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis","volume":"38","author":"Ilan","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12307-011-0082-7","article-title":"Significance of heparanase in cancer and inflammation","volume":"5","author":"Vlodavsky","year":"2012","journal-title":"Canc. Microenviron.: Offic. J. Int. Canc. Microenviron. Soc."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.matbio.2013.03.002","article-title":"Involvement of heparanase in atherosclerosis and other vessel wall pathologies","volume":"32","author":"Vlodavsky","year":"2013","journal-title":"Matrix Biol.: J. Int. Soc. Matrix Biol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.atherosclerosis.2012.09.030","article-title":"Increased expression of heparanase in symptomatic carotid atherosclerosis","volume":"226","author":"Osterholm","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib20","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/jcp.20625","article-title":"Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass","volume":"207","author":"Kram","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1096\/fj.03-0572com","article-title":"Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior","volume":"18","author":"Zcharia","year":"2004","journal-title":"FASEB J.: Offic. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib22","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1634\/stemcells.2007-0065","article-title":"Disruption of heparan and chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein signaling pathways","volume":"25","author":"Manton","year":"2007","journal-title":"Stem Cell."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib23","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1158\/0008-5472.CAN-10-2179","article-title":"Heparanase enhances local and systemic osteolysis in multiple myeloma by upregulating the expression and secretion of rankl","volume":"70","author":"Yang","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bone.2013.07.024","article-title":"Heparanase inhibits osteoblastogenesis and shifts bone marrow progenitor cell fate in myeloma bone disease","volume":"57","author":"Ruan","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib25","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1093\/bioinformatics\/btp279","article-title":"Generegionscan: A bioconductor package for probe-level analysis of specific, small regions of the genome","volume":"25","author":"Folkersen","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib26","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ajpath.2013.10.016","article-title":"Ige receptor-mediated mast-cell renin release","volume":"184","author":"Aldi","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib27","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","article-title":"Osf2\/cbfa1: a transcriptional activator of osteoblast differentiation","volume":"89","author":"Ducy","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib28","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1161\/CIRCRESAHA.110.234088","article-title":"Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes","volume":"108","author":"Fadini","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib29","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1161\/ATVBAHA.112.300128","article-title":"Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification","volume":"33","author":"New","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1161\/CIRCRESAHA.108.183053","article-title":"Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries","volume":"104","author":"Speer","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib31","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/cvr\/cvs126","article-title":"Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study","volume":"94","author":"Naik","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib32","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1073\/pnas.89.1.426","article-title":"Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily","volume":"89","author":"Shiraga","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00223-001-1121-z","article-title":"Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone","volume":"71","author":"Boskey","year":"2002","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/jor.20544","article-title":"Altered osteoclast development and function in osteopontin deficient mice","volume":"26","author":"Franzen","year":"2008","journal-title":"J. Orthop. Res.:Offic. Publ. Orthop. Res. Soc."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib35","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/CIRCRESAHA.108.181305","article-title":"Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization","volume":"103","author":"Ewence","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib36","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.yexmp.2015.11.010","article-title":"Multinucleated giant cells in atherosclerotic plaques of human carotid arteries: identification of osteoclast-like cells and their specific proteins in artery wall","volume":"99","author":"Qiao","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/CIRCRESAHA.116.310262","article-title":"Human alternative macrophages populate calcified areas of atherosclerotic lesions and display impaired rankl-induced osteoclastic bone resorption activity","volume":"121","author":"Chinetti-Gbaguidi","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s004280050289","article-title":"Observations on bone formation and remodelling in advanced atherosclerotic lesions of human carotid arteries","volume":"433","author":"Jeziorska","year":"1998","journal-title":"Virchows Arch."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib39","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.2174\/138161207781039742","article-title":"Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate","volume":"13","author":"Vlodavsky","year":"2007","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib40","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/jcb.20007","article-title":"Low doses and high doses of heparin have different effects on osteoblast-like saos-2 cells in vitro","volume":"91","author":"Hausser","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/iub.70","article-title":"Heparin--a unique stimulator of human colon cancer cells' growth","volume":"60","author":"Chatzinikolaou","year":"2008","journal-title":"IUBMB Life"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib42","doi-asserted-by":"crossref","first-page":"15942","DOI":"10.1074\/jbc.M809577200","article-title":"Lack of l-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling","volume":"284","author":"Jia","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib43","doi-asserted-by":"crossref","first-page":"26884","DOI":"10.1074\/jbc.M600806200","article-title":"Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors","volume":"281","author":"Jastrebova","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib44","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1093\/cvr\/cvx178","article-title":"Regulation of vascular smooth muscle cell calcification by syndecan-4\/fgf-2\/pkcalpha signalling and cross-talk with tgfbeta","volume":"113","author":"Borland","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib45","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1097\/01.ASN.0000141960.01035.28","article-title":"Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in esrd","volume":"15","author":"Reynolds","year":"2004","journal-title":"J. Am. Soc. Nephrol.:JASN"},{"key":"10.1016\/j.atherosclerosis.2018.12.027_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1681\/ASN.2009060640","article-title":"Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification","volume":"21","author":"Shroff","year":"2010","journal-title":"J. Am. Soc. Nephrol.:JASN"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915018315582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915018315582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T13:55:25Z","timestamp":1553003725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915018315582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":46,"alternative-id":["S0021915018315582"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2018.12.027","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual roles of heparanase in human carotid plaque calcification","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2018.12.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}