{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:02:04Z","timestamp":1786600924514,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG6G0551"],"award-info":[{"award-number":["CMRPG6G0551"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.atherosclerosis.2019.07.009","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T11:05:28Z","timestamp":1562843128000},"page":"137-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Effect of initiating statin therapy on long-term outcomes of patients with dyslipidemia after intracerebral hemorrhage"],"prefix":"10.1016","volume":"288","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9348-8153","authenticated-orcid":false,"given":"Ming-Shyan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Tai","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-4369","authenticated-orcid":false,"given":"Victor","family":"Chien-Chia Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wey-Yil","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Min","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.atherosclerosis.2019.07.009_bib1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ncl.2008.07.003","article-title":"Epidemiology of ischemic and hemorrhagic stroke: incidence, prevalence, mortality, and risk factors","volume":"26","author":"Grysiewicz","year":"2008","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib2","first-page":"jnnp","article-title":"Long-term prognosis after intracerebral haemorrhage: systematic review and meta-analysis","author":"Poon","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijcard.2017.02.042","article-title":"Patients with intracranial bleeding and atrial fibrillation treated with left atrial appendage occlusion: results from the Amplatzer Cardiac Plug registry","volume":"236","author":"Tzikas","year":"2017","journal-title":"Int. J. Cardiol."},{"issue":"39","key":"10.1016\/j.atherosclerosis.2019.07.009_bib4","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1093\/eurheartj\/ehw272","article-title":"2016 ESC\/EAS guidelines for the management of dyslipidaemias","volume":"37","author":"Catapano","year":"2016","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2019.07.009_bib5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/STROKEAHA.112.668277","article-title":"Statin therapy and outcome after ischemic stroke: systematic review and meta-analysis of observational studies and randomized trials","volume":"44","author":"N\u00ed Chr\u00f3in\u00edn","year":"2013","journal-title":"Stroke"},{"issue":"18","key":"10.1016\/j.atherosclerosis.2019.07.009_bib6","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1212\/WNL.0b013e3182194be9","article-title":"Statin use and outcome after intracerebral hemorrhage: case control study and meta-analysis","volume":"76","author":"Biffi","year":"2011","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.atherosclerosis.2019.07.009_bib7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa061894","article-title":"Stroke prevention by aggressive reduction in cholesterol levels (SPARCL) investigators. High-dose atorvastatin after stroke or transient ischemic attack","volume":"355","author":"Amarenco","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib8","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1212\/01.wnl.0000296277.63350.77","article-title":"SPARCL investigators. Hemorrhagic stroke in the stroke prevention by aggressive reduction in cholesterol levels study","volume":"70","author":"Goldstein","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib9","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(04)15690-0","article-title":"Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions","volume":"363","author":"Collins","year":"2004","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2019.07.009_bib10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1161\/STROKEAHA.107.488791","article-title":"Statin treatment and the occurrence of hemorrhagic stroke in patients with a history of cerebrovascular disease","volume":"39","author":"Vergouwen","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1001\/archneurol.2010.356","article-title":"Statin use following intracerebral hemorrhage: a decision analysis","volume":"68","author":"Westover","year":"2011","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.atherosclerosis.2019.07.009_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171379","article-title":"Low cholesterol level associated with severity and outcome of spontaneous intracerebral hemorrhage: results from Taiwan Stroke Registry","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib13","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1161\/CIRCULATIONAHA.108.795666","article-title":"Low-density lipoprotein cholesterol concentrations and death due to intraparenchymal hemorrhage: the Ibaraki Prefectural Health Study","volume":"119","author":"Noda","year":"2009","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.atherosclerosis.2019.07.009_bib14","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1161\/STROKEAHA.112.655894","article-title":"Statin therapy and the risk of intracerebral hemorrhage: a meta-analysis of 31 randomized controlled trials","volume":"43","author":"McKinney","year":"2012","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.atherosclerosis.2019.07.009_bib15","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.amjcard.2008.07.023","article-title":"Comparison of effectiveness of atorvastatin 10 mg versus 80 mg in reducing major cardiovascular events and repeat revascularization in patients with previous percutaneous coronary intervention (post hoc analysis of the Treating to New Targets [TNT] Study)","volume":"102","author":"Johnson","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib16","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Fourier Steering Committee and Investigators. Evolocumab and clinical outcomes in patients with cardiovascular disease","volume":"376","author":"Sabatine","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.atherosclerosis.2019.07.009_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.487","article-title":"Statin use after intracerebral hemorrhage: a 10\u2010year nationwide cohort study","volume":"6","author":"Tai","year":"2016","journal-title":"Brain Behav"},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.wneu.2017.12.020","article-title":"Pre\u2013intracerebral hemorrhage and in-hospital statin use in intracerebral hemorrhage: a systematic review and meta-analysis","volume":"111","author":"Lei","year":"2018","journal-title":"World Neurosurg"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2019.07.009_bib19","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/ene.12649","article-title":"Early statin therapy in patients with acute intracerebral hemorrhage without prior statin use","volume":"22","author":"Chen","year":"2015","journal-title":"Eur. J. Neurol."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2019.07.009_bib20","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/cns.12274","article-title":"Use of statin during hospitalization improves the outcome after intracerebral hemorrhage","volume":"20","author":"Pan","year":"2014","journal-title":"CNS Neurosci. Ther."},{"issue":"11","key":"10.1016\/j.atherosclerosis.2019.07.009_bib21","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1001\/jamaneurol.2014.2124","article-title":"Effect of statin use during hospitalization for intracerebral hemorrhage on mortality and discharge disposition","volume":"71","author":"Flint","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib22","first-page":"301","article-title":"Match-study of statin therapy in spontaneous intracerebral hemorrhage: is the discontinuation reasonable?","volume":"60","author":"Tapia-Perez","year":"2016","journal-title":"J. Neurosurg. Sci."},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib23","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1161\/STROKEAHA.117.017358","article-title":"Use of statins and outcomes in intracerebral hemorrhage patients","volume":"48","author":"Siddiqui","year":"2017","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2019.07.009_bib24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.je.2016.08.003","article-title":"Validation of a novel claims-based stroke severity index in patients with intracerebral hemorrhage","volume":"27","author":"Hung","year":"2017","journal-title":"J. Epidemiol."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2019.07.009_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112257","article-title":"Concordance between patient self-reports and claims data on clinical diagnoses, medication use, and health system utilization in Taiwan","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2019.07.009_bib26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pds.2087","article-title":"Validation of the national health insurance research database with ischemic stroke cases in taiwan","volume":"20","author":"Cheng","year":"2011","journal-title":"Pharmacoepidemiol. Drug Saf."},{"issue":"9","key":"10.1016\/j.atherosclerosis.2019.07.009_bib27","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/aje\/kwq224","article-title":"Statistical criteria for selecting the optimal number of untreated subjects matched to each treated subject when using many-to-one matching on the propensity score","volume":"172","author":"Austin","year":"2010","journal-title":"Am. J. Epidemiol."},{"issue":"7","key":"10.1016\/j.atherosclerosis.2019.07.009_bib28","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/jcbfm.2015.36","article-title":"Perihematoma cerebral blood flow is unaffected by statin use in acute intracerebral hemorrhage patients","volume":"35","author":"Gioia","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"7","key":"10.1016\/j.atherosclerosis.2019.07.009_bib29","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1161\/STROKEAHA.107.508861","article-title":"Effect of statins on intracerebral hemorrhage outcome and recurrence","volume":"39","author":"FitzMaurice","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib30","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/00003246-199903000-00021","article-title":"Rate of 24-hour blood pressure decline and mortality after spontaneous intracerebral hemorrhage: a retrospective analysis with a random effects regression model","volume":"27","author":"Qureshi","year":"1999","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2019.07.009_bib31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/STROKEAHA.117.019322","article-title":"Statin treatment in patients with intracerebral hemorrhage","volume":"49","author":"Endres","year":"2018","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2019.07.009_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0028-1082064","article-title":"Use of statins for the treatment of spontaneous intracerebral hemorrhage: results of a pilot study","volume":"70","author":"Tapia-Perez","year":"2009","journal-title":"Cent. Eur. Neurosurg."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2019.07.009_bib33","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1161\/STROKEAHA.111.645978","article-title":"Association of statins and statin discontinuation with poor outcome and survival after intracerebral hemorrhage","volume":"43","author":"Dowlatshahi","year":"2012","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2019.07.009_bib34","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1253\/circj.CJ-10-0110","article-title":"Pleiotropic effects of statins","volume":"74","author":"Zhou","year":"2010","journal-title":"Circ. J."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2019.07.009_bib35","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jacl.2017.01.001","article-title":"Effects of statin therapy on cerebrovascular and renal outcomes in patients with predialysis advanced chronic kidney disease and dyslipidemia","volume":"11","author":"Chung","year":"2017","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2019.07.009_bib36","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ejmech.2014.08.037","article-title":"Statins in therapy: understanding their hydrophilicity, lipophilicity, binding to 3-hydroxy-3-methylglutaryl-CoA reductase, ability to cross the blood brain barrier and metabolic stability based on electrostatic molecular orbital studies","volume":"85","author":"Fong","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"27","key":"10.1016\/j.atherosclerosis.2019.07.009_bib37","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1093\/eurheartj\/ehy182","article-title":"Adverse effects of statin therapy: perception vs. the evidence\u2013focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract","volume":"39","author":"Mach","year":"2018","journal-title":"Eur. Heart J."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915019314005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915019314005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:40:28Z","timestamp":1758156028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915019314005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":37,"alternative-id":["S0021915019314005"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2019.07.009","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of initiating statin therapy on long-term outcomes of patients with dyslipidemia after intracerebral hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2019.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}