{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:17:29Z","timestamp":1780049849907,"version":"3.53.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"am","delay-in-days":336,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.atherosclerosis.2020.09.012","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T08:11:56Z","timestamp":1600935116000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Iodine-enhanced micro-computed tomography of atherosclerotic plaque morphology complements conventional histology"],"prefix":"10.1016","volume":"313","author":[{"given":"Trevor S.","family":"Self","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-3447","authenticated-orcid":false,"given":"Anne-Marie","family":"Ginn-Hedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney N.","family":"Kaulfus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie E.","family":"Newell-Fugate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-5719","authenticated-orcid":false,"given":"Brad R.","family":"Weeks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine L.","family":"Heaps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/0192623319826585","article-title":"Introduction to currently applied device pathology","volume":"47","author":"Friedemann","year":"2019","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/jemt.20491","article-title":"Surface imaging microscopy using an ultramiller for large volume 3D reconstruction of wax- and resin-embedded tissues","volume":"70","author":"Gerneke","year":"2007","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib3","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1100\/tsw.2009.154","article-title":"Visualizing vertebrate embryos with episcopic 3D imaging techniques","volume":"9","author":"Geyer","year":"2009","journal-title":"Sci. World J."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.gde.2011.07.004","article-title":"Imaging heart development using high-resolution episcopic microscopy","volume":"21","author":"Mohun","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib5","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuroimage.2007.04.067","article-title":"Comparison of fiber tracts derived from in-vivo DTI tractography with 3D histological neural tract tracer reconstruction on a macaque brain","volume":"37","author":"Dauguet","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib6","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.matchar.2010.09.012","article-title":"X-ray microtomography","volume":"61","author":"Landis","year":"2010","journal-title":"Mater. Char."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000442387","article-title":"The role of micro-CT in 3D histology imaging","volume":"83","author":"Senter-Zapata","year":"2016","journal-title":"Pathobiology"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.micron.2011.10.002","article-title":"X-ray microtomography in biology","volume":"43","author":"Mizutani","year":"2012","journal-title":"Micron"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ymeth.2009.08.007","article-title":"Application of micro-CT in small animal imaging","volume":"50","author":"Schambach","year":"2010","journal-title":"Methods"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1118\/1.597038","article-title":"A high\u2010resolution XRII\u2010based quantitative volume CT scanner","volume":"20","author":"Holdsworth","year":"1993","journal-title":"Med. Phys."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib11","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1073\/pnas.1720862115","article-title":"Three-dimensional virtual histology enabled through cytoplasm-specific X-ray stain for microscopic and nanoscopic computed tomography","volume":"115","author":"Busse","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1472-6793-9-11","article-title":"MicroCT for comparative morphology: simple staining methods allow high-contrast 3D imaging of diverse non-mineralized animal tissues","volume":"9","author":"Metscher","year":"2009","journal-title":"BMC Physiol."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/1baecd19-92b6-4683-b7d7-39c13a3f2e15","article-title":"Contrast enhanced micro-computed tomography resolves the 3-dimensional morphology of the cardiac conduction system in mammalian hearts","volume":"7","author":"Stephenson","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/jez.b.22561","article-title":"Iodine-enhanced micro-CT imaging: methodological refinements for the study of the soft-tissue anatomy of post-embryonic vertebrates","volume":"322","author":"Gignac","year":"2014","journal-title":"J. Exp. Zool. B Mol. Dev. Evol."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib15","first-page":"144","article-title":"Soft tissue discrimination with contrast agents using micro-CT scanning","author":"Descamps","year":"2014","journal-title":"Belg. J. Zool."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep14088","article-title":"Three-dimensional non-destructive soft-tissue visualization with X-ray staining micro-tomography","volume":"5","author":"e Silva","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib17","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/ten.tec.2008.0436","article-title":"Micro-computed tomographical imaging of soft biological materials using contrast techniques","volume":"15","author":"Faraj","year":"2009","journal-title":"Tissue Eng. C Methods"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib18","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1021\/cr200358s","article-title":"X-ray-computed tomography contrast agents","volume":"113","author":"Lusic","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib19","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/dvdy.21857","article-title":"MicroCT for developmental biology: a versatile tool for high-contrast 3D imaging at histological resolutions","volume":"238","author":"Metscher","year":"2009","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jbiomech.2010.08.027","article-title":"Micro-computed tomography with iodine staining resolves the arrangement of muscle fibres","volume":"44","author":"Jeffery","year":"2011","journal-title":"J. Biomech."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12899-015-0019-3","article-title":"An investigation of the efficacy and mechanism of contrast-enhanced X-ray computed tomography utilizing iodine for large specimens through experimental and simulation approaches","volume":"15","author":"Li","year":"2015","journal-title":"BMC Physiol."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/joa.12449","article-title":"Diffusible iodine-based contrast-enhanced computed tomography (diceCT): an emerging tool for rapid, high-resolution, 3-D imaging of metazoan soft tissues","volume":"228","author":"Gignac","year":"2016","journal-title":"J. Anat."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib23","first-page":"1230","article-title":"Noninvasive detection of coronary lesions using 16-detector multislice spiral computed tomography technology: initial clinical results","volume":"44","author":"Kuettner","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib24","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3174\/ajnr.A0950","article-title":"High-resolution CT imaging of carotid artery atherosclerotic plaques","volume":"29","author":"Wintermark","year":"2008","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib25","first-page":"1","article-title":"Measurement of renal functional response using iohexol clearance\u2014a study of different outpatient procedures","author":"Lill\u00e5s","year":"2019","journal-title":"Clinic. Kidney J."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179542","article-title":"Effects of coconut oil on glycemia, inflammation, and urogenital microbial parameters in female Ossabaw mini-pigs","volume":"12","author":"Newell-Fugate","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib27","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","article-title":"3D slicer as an image computing platform for the quantitative imaging network","volume":"30","author":"Fedorov","year":"2012","journal-title":"Magn. Reson. Imag."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib28","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3233\/THC-151010","article-title":"Quantitative micro-CT based coronary artery profiling using interactive local thresholding and cylindrical coordinates","volume":"23","author":"Panetta","year":"2015","journal-title":"Technol. Health Care"},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2217\/iim.12.13","article-title":"CT artifacts: causes and reduction techniques","volume":"4","author":"Boas","year":"2012","journal-title":"Imag. Med."},{"key":"10.1016\/j.atherosclerosis.2020.09.012_bib31","series-title":"Staining Techniques for 3-D Pathological Analysis","author":"Darrouzet","year":"2011"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915020305311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915020305311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:43:10Z","timestamp":1758156190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915020305311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":31,"alternative-id":["S0021915020305311"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2020.09.012","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iodine-enhanced micro-computed tomography of atherosclerotic plaque morphology complements conventional histology","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2020.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}