{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:08:12Z","timestamp":1783948092472,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20214Y0002"],"award-info":[{"award-number":["20214Y0002"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81941017"],"award-info":[{"award-number":["81941017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970706"],"award-info":[{"award-number":["81970706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970728"],"award-info":[{"award-number":["81970728"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770842"],"award-info":[{"award-number":["81770842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870560"],"award-info":[{"award-number":["81870560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR3069B"],"award-info":[{"award-number":["SHDC2020CR3069B"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR1001A"],"award-info":[{"award-number":["SHDC2020CR1001A"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20152508"],"award-info":[{"award-number":["20152508"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20161307"],"award-info":[{"award-number":["20161307"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.atherosclerosis.2022.03.031","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T01:59:16Z","timestamp":1649210356000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Changes in adiposity modulate the APOA5 genetic effect on blood lipids: A longitudinal cohort study"],"prefix":"10.1016","volume":"350","author":[{"given":"Hong","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajie","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiange","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieli","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)","volume":"41","author":"Mach","year":"2019","journal-title":"Eur. Heart J."},{"issue":"25","key":"10.1016\/j.atherosclerosis.2022.03.031_bib2","first-page":"e1046","article-title":"Guideline on the management of blood cholesterol: executive summary: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines","volume":"139","author":"Grundy","year":"2019","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2022.03.031_bib3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/CIRCULATIONAHA.113.005757","article-title":"Racial\/ethnic differences in dyslipidemia patterns","volume":"129","author":"Frank","year":"2014","journal-title":"Circulation"},{"issue":"9726","key":"10.1016\/j.atherosclerosis.2022.03.031_bib4","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/S0140-6736(10)60545-4","article-title":"Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies","volume":"375","author":"Consortium","year":"2010","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.atherosclerosis.2022.03.031_bib5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/CIRCRESAHA.115.306249","article-title":"Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology","volume":"118","author":"Nordestgaard","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.atherosclerosis.2013.12.013","article-title":"Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?","volume":"233","author":"Li","year":"2014","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.atherosclerosis.2022.03.031_bib7","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2022.03.031_bib8","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1038\/ng.3977","article-title":"Exome-wide association study of plasma lipids in> 300,000 individuals","volume":"49","author":"Liu","year":"2017","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2022.03.031_bib9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41588-018-0047-6","article-title":"Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases","volume":"50","author":"Kanai","year":"2018","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-08008-w","article-title":"Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity","volume":"10","author":"Kilpel\u00e4inen","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib11","first-page":"1","article-title":"Association of BUD13-ZNF259-APOA5-APOA1-SIK3 cluster polymorphism in 11q23. 3 and structure of APOA5 with increased plasma triglyceride levels in a Korean population","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng.291","article-title":"Common variants at 30 loci contribute to polygenic dyslipidemia","volume":"41","author":"Kathiresan","year":"2009","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng.269","article-title":"Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts","volume":"41","author":"Aulchenko","year":"2009","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2022.03.031_bib14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng.76","article-title":"Newly identified loci that influence lipid concentrations and risk of coronary artery disease","volume":"40","author":"Willer","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.atherosclerosis.2022.03.031_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.atherosclerosis.2017.07.030","article-title":"Alterations in plasma triglycerides lipolysis in patients with history of multifactorial chylomicronemia","volume":"265","author":"Marmontel","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2022.03.031_bib16","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.exger.2018.05.007","article-title":"Habitual aerobic exercise, gene APOA5 named rs662799 SNP and response of blood lipid and lipoprotein phenotypes among older Chinese adult","volume":"110","author":"Liu","year":"2018","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227357","article-title":"Genome-wide association study of metabolic syndrome in Korean populations","volume":"15","author":"Oh","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12872-017-0735-7","article-title":"Association of rs662799 in APOA5 with CAD in Chinese Han population","volume":"18","author":"Chen","year":"2018","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.atherosclerosis.2022.03.031_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2017.01.024","article-title":"Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants","volume":"258","author":"Shahid","year":"2017","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Collaborators","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.atherosclerosis.2022.03.031_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.metabol.2018.11.005","article-title":"Obesity and dyslipidemia","volume":"92","author":"Vekic","year":"2019","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12944-019-1170-9","article-title":"Interaction between adipocytes and high-density lipoprotein:new insights into the mechanism of obesity-induced dyslipidemia and atherosclerosis","volume":"18","author":"Zhang","year":"2019","journal-title":"Lipids Health Dis."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-016-0354-9","article-title":"Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight\/obesity on serum lipid levels in a Chinese Han population","volume":"15","author":"Zhi","year":"2016","journal-title":"Lipids Health Dis."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2840-11-123","article-title":"Several genetic polymorphisms interact with overweight\/obesity to influence serum lipid levels","volume":"11","author":"Yin","year":"2012","journal-title":"Cardiovasc. Diabetol."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2022.03.031_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/MOL.0000000000000160","article-title":"Gene\u2013environment interaction in dyslipidemia","volume":"26","author":"Cole","year":"2015","journal-title":"Curr. Opin. Lipidol."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2022.03.031_bib26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41440-018-0137-y","article-title":"Longitudinal interaction between APOA5-1131T> C and overweight in the acceleration of age-related increase in arterial stiffness through the regulation of circulating triglycerides","volume":"42","author":"Kim","year":"2019","journal-title":"Hypertens. Res."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2022.03.031_bib27","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1194\/jlr.P119000226","article-title":"A genome-wide search for gene-by-obesity interaction loci of dyslipidemia in Koreans shows diverse genetic risk alleles","volume":"60","author":"Kang","year":"2019","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2022.03.031_bib28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00125-015-3788-0","article-title":"Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis","volume":"59","author":"Xu","year":"2016","journal-title":"Diabetologia"},{"issue":"19","key":"10.1016\/j.atherosclerosis.2022.03.031_bib29","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Panel on Detection, Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)","volume":"285","author":"Expert","year":"2001","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.atherosclerosis.2022.03.031_bib30","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.metabol.2010.02.008","article-title":"Contribution of APOA5\u22121131C allele to the increased susceptibility of diabetes mellitus in association with higher triglyceride in Korean women","volume":"59","author":"Lee","year":"2010","journal-title":"Metabolism"},{"key":"10.1016\/j.atherosclerosis.2022.03.031_bib31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.atherosclerosis.2017.08.003","article-title":"The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: evidence from a meta-analysis","volume":"265","author":"Au","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2022.03.031_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jacl.2020.05.003","article-title":"Gene\u2013environment interaction between APOA5 c.553G.T and pregnancy in hypertriglyceridemia-induced acute pancreatitis","volume":"14","author":"Pu","year":"2020","journal-title":"J. Clin. Lipidol."},{"issue":"8","key":"10.1016\/j.atherosclerosis.2022.03.031_bib33","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jand.2020.01.009","article-title":"Alcohol, carbohydrate, and calcium intakes and smoking interactions with APOA5 rs662799 and rs2266788 were associated with elevated plasma triglyceride concentrations in a cross-sectional study of Korean adults","volume":"120","author":"Park","year":"2020","journal-title":"J. Acad. Nutr. Diet."},{"issue":"27","key":"10.1016\/j.atherosclerosis.2022.03.031_bib34","doi-asserted-by":"crossref","first-page":"27941","DOI":"10.1074\/jbc.M403240200","article-title":"ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis","volume":"279","author":"Schaap","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2022.03.031_bib35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12944-018-0833-2","article-title":"New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients","volume":"17","author":"Su","year":"2018","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.atherosclerosis.2022.03.031_bib36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cca.2020.01.015","article-title":"The exchangeable apolipoproteins in lipid metabolism and obesity","volume":"503","author":"Su","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.atherosclerosis.2022.03.031_bib37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jff.2013.12.006","article-title":"Nutraceuticals and dyslipidaemia: beyond the common therapeutics","volume":"6","author":"Scicchitano","year":"2014","journal-title":"J. Funct.Foods"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915022001654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915022001654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:46:20Z","timestamp":1778643980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915022001654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":37,"alternative-id":["S0021915022001654"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2022.03.031","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in adiposity modulate the APOA5 genetic effect on blood lipids: A longitudinal cohort study","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2022.03.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}